Results 81 to 90 of about 10,640,595 (395)

Kinetics and cellular site of glycolipid loading control [PDF]

, 2009
CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell- and Th2 cell-type cytokines.
Arora, Pooja, Baena, Andres, Baine, Ian, Bricard, Gabriel, Goldberg, Michael F., Im, Jin S., Jerud, Elliot S., Molano, Alberto, Ndonye, Rachel M., Venkataswamy, Manjunatha M., Yu, Karl O.A.   +10 more
core  

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Eosinophils: Cells known for over 140 years with broad and new functions

Allergology International, 2021
Eosinophils are multifunctional leukocytes, being involved in the host defense against helminth infection, tissue homeostasis and repair of injured tissue.
Ami Aoki, Kiyoshi Hirahara, Masahiro Kiuchi, Toshinori Nakayama   +3 more
doaj  

The Essential Role Played by B Cells in Supporting Protective Immunity Against Trichuris muris Infection Is by Controlling the Th1/Th2 Balance in the Mesenteric Lymph Nodes and Depends on Host Genetic Background

Frontiers in Immunology, 2019
How B cells contribute to protective immunity against parasitic nematodes remains unclear, with their importance as accessory cells underexplored. In this study, anti-CD20 monoclonal antibody (α-CD20 mAb)-mediated depletion of B cells from C57BL/6 mice ...
Rinal Sahputra, Dominik Ruckerl, Kevin N. Couper, Werner Muller, Kathryn J. Else   +4 more
doaj   +1 more source

IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation.

PLoS ONE, 2021
While IFNγ is a well-known cytokine that actively promotes the type I immune response, it is also known to suppress the type II response by inhibiting the differentiation and proliferation of Th2 cells. However, the mechanism by which IFNγ suppresses Th2
Murshed H Sarkar, Ryoji Yagi, Yukihiro Endo, Ryo Koyama-Nasu, Yangsong Wang, Ichita Hasegawa, Toshihiro Ito, Ilkka S Junttila, Jinfang Zhu, Motoko Y Kimura, Toshinori Nakayama   +10 more
doaj   +1 more source

Signaling via interleukin-4, receptor alpha chain is required for successful vaccination against schistosomiasis in BALB/c mice [PDF]

, 2001
Radiation-attenuated (RA) schistosome larvae are potent stimulators of innate immune responses at the skin site of exposure (pinna) that are likely to be important factors in the development of Th1-mediated protective immunity.
Anderson S., Anderson S., Anderson S., Artis D., Bancroft A. J., Bancroft A. J., Barner M., Belkaid Y., Brewer J. M., Brombacher F., Coulson P. S., D'Andrea A., de Andres B., Dean D. A., Delgado V., Donaldson D. D., Faquim-Mauro E. L., Galbiati F., Grunig G., Guler M. L., Hilton D. J., Hoffmann K. F., Hsieh C. S., James S. L., Jankovic D., Jankovic D., Jankovic D., King C. L., King C. L., Kopf M., Magram J., Mangold B. L., Matthews D. J., Mattner F., McKenzie G. J., Metwali A., Mohrs M., Mohrs M., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Muchamuel T., Nelms K., Noben-Trauth N., Noben-Trauth N., Noben-Trauth N., O'Garra A., Pearce E. J., Reiner S. L., Scott P., Seder R. A., Sher A., Shibuya K., Smythies L. E., Smythies L. E., Street M., Szabo S. J., Urban J. F., Wilson R. A., Wynn T. A., Wynn T. A., Zurawski G.   +64 more
core   +2 more sources

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

Critical Involvement of CD44 in T Helper Type 2 Cell-Mediated Eosinophilic Airway Inflammation in a Mouse Model of Acute Asthma

Frontiers in Immunology, 2022
Interactions between CD44 and hyaluronan (HA) are crucial for recruiting leukocytes to inflamed tissues. This review summarizes findings from our studies of the roles of CD44-HA interactions in leukocyte trafficking, with a particular focus on airway T ...
Shigeki Katoh
doaj   +1 more source

The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype [PDF]

, 2013
We previously demonstrated inhibition of ovalbumin (OVA)-induced allergic airway hyper-responsiveness in the mouse using ES-62, a phosphorylcholine-containing glycoprotein secreted by the filarial nematode, Acanthocheilonema viteae.
Adams, Anderson, Barczyk, Barin, Bosse, Bossie, Busse, Busse, Carter, Charles McSharry, Chen, Christina N. Steiger, Cobbold, Dias, Dorothy E. Kean, Durrant, Durrant, Feltis, Finotto, Fujiwara, Gilfillan, Goodridge, Goodridge, Goodridge, Harnett, Havaux, Hellings, Holgate, Houston, Ito, Ivonne Siebeke, Iwakura, Jager, Jeannin, Jennifer C. Coltherd, Justyna Rzepecka, Kawaguchi, Kolls, Kolls, Lajoie, Lal, Lamyaa Al-Riyami, Leonardi-Bee, Lima, Linden, Ma, Margaret M. Harnett, Marshall, McInnes, McKay, McSorley, Melendez, Milner, Morton, Munthe-Kaas, Murdock, Nakae, Pichavant, Pineda, Raby, Schnoeller, Schnyder-Candrian, Shreiner, Strachan, Szabo, Traves, Umetsu, Wang, Wang, Whelan, William Harnett, Wilson, Wilson, Yang, Yang   +74 more
core   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, Volume 599, Issue 7, Page 927-951, April 2025.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source