Results 91 to 100 of about 55,234 (296)
Clinical Pharmacology &Therapeutics, EarlyView.One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba +7 more
wiley +1 more source
A guide to neuromodulation in drug‐resistant epilepsy
Epileptic Disorders, EarlyView.Abstract Neuromodulation is approved for the treatment of drug‐resistant epilepsy. It has been increasingly utilized over the past two decades with the approval of deep brain stimulation (DBS) and responsive neurostimulation (RNS) in addition to vagus nerve stimulation (VNS)—particularly in patients who are not deemed to be good resective surgical ...
Prachi Parikh +10 more
wiley +1 more source
Brain Feedback and Adaptive Resonance in Speech Perception [PDF]
, 1999 The brain contains ubiquitous reciprocal bottom-up and top-down intercortical and thalamocortical pathways. These resonating feedback pathways may be essential for stable learning of speech and language codes and for context-sensitive selection and ...
Grossberg, Stephen
core +2 more sources
Brain : a journal of neurology, 2019 Although the molecular effects of many anaesthetics have been well characterized, a network-level explanation for how these changes lead to loss of consciousness remains unclear.
M. Malekmohammadi +4 more
semanticscholar +1 more source
Epilepsia, EarlyView.Abstract Objective The thalamus is a key hub in seizure propagation, and its nuclei are emerging targets for neuromodulation. However, the contributions of individual nuclei to epileptic networks remain unclear, particularly in children, who are less studied than adults.
Xiyu Feng +11 more
wiley +1 more source
Frontiers in Pharmacology, 2022 Background: Electroencephalography (EEG) recordings under propofol exhibit an increase in slow and alpha oscillation power and dose-dependent phase–amplitude coupling (PAC), which underlie GABAA potentiation and the central role of thalamocortical ...
Jingyao Jiang +12 more
doaj +1 more source
Alice in wonderland syndrome. a clinical and pathophysiological review [PDF]
, 2016 Alice in Wonderland Syndrome (AIWS) is a perceptual disorder, principally involving visual and somesthetic integration, firstly reported by Todd, on the literary suggestion of the strange experiences described by Lewis Carroll in Alice in Wonderland ...
DI PIERO, Vittorio +3 more
core +3 more sources
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2019 BACKGROUND Converging evidence implicates abnormal thalamocortical interactions in the pathophysiology of schizophrenia. This evidence includes consistent findings of increased resting-state functional connectivity of the thalamus with somatosensory and ...
B. Baran +7 more
semanticscholar +1 more source
Epilepsia, EarlyView.Abstract Objective Status epilepticus (SE) is the most severe expression of seizures, encompassing both SE with prominent motor symptoms and nonconvulsive SE (NCSE). Ictal–interictal continuum (IIC), an electroencephalographic phenomenon, is characterized by periodic discharges (PD), spike‐and‐waves or sharp‐and‐waves (SW), or lateralized rhythmic ...
Pilar Bosque‐Varela +15 more
wiley +1 more source
Frontiers in Neuroanatomy, 2009 The organization and connections of the primary visual area (V1) were examined in mice that lacked functional rods (Gnat-/-), but had normal cone function.
DeLaine D Larsen +5 more
doaj +1 more source