Results 81 to 90 of about 2,702 (213)
American Journal of Hematology, Volume 101, Issue 4, Page 718-727, April 2026.ABSTRACT Sickle cell disease (SCD) is a chronic inflammatory state, characterized by increased plasma values of inflammatory and angiogenic proteins. Although red blood cell (RBC) transfusion is known to have immunomodulatory effects in other conditions, its potential effects on the inflammatory state in SCD remain largely unknown.
Lydian A. de Ligt +9 more
wiley +1 more source
Creative and Adaptive Solutions for Early Diagnosis of Sickle Cell Disease in Sub‐Saharan Africa
American Journal of Hematology, Volume 101, Issue S1, Page 17-32, April 2026.ABSTRACT Many of the children with sickle cell disease born in sub‐Saharan Africa remain undiagnosed and untreated. Increasing capacity and infrastructure to support diagnostic and screening programs in high income countries have enabled near universal survival into adulthood.
Luke R. Smart +2 more
wiley +1 more source
American Journal of Hematology, Volume 101, Issue S1, Page 5-16, April 2026.What are the available data on incidence & prevalence prognosis risk factors of severity of sickle cell disease in sub‐Saharan Africa? ABSTRACT Sickle Cell Disease (SCD) is highly prevalent in sub‐Saharan Africa. Epidemiological data remain sparse, but regional screening and research initiatives are expanding.
Brigitte Ranque +2 more
wiley +1 more source
Haematologica, 1995 Thalassemia intermedia is a clinical definition applied to patients whose clinical phenotype is milder than that of thalassemia major. Criteria used to define thalassemia intermedia including age at presentation, hemoglobin or fetal hemoglobin levels and transfusion independence, are unsatisfactory. The possibility of typing the molecular defect allows
C. Camaschella, M.D. Cappellini
openaire +2 more sources
Genetics and Genomics in Sickle Cell Disease in Africa
American Journal of Hematology, Volume 101, Issue S1, Page 47-55, April 2026.ABSTRACT Advanced genomic technologies are revolutionizing our ability to understand complex diseases. Large‐scale population studies are needed to realize the potential of using individual genetic information to personalize treatments for better patient outcomes for chronic non‐communicable diseases, such as sickle cell disease (SCD).
Siana Nkya +2 more
wiley +1 more source
In vitro inhibition of BCL11A gene expression by RNAi for the Treatment of ?-Thalassemia
Mediterranean Journal of Hematology and Infectious Diseases, 2014 Thalassemias are general genetic disorders in the Indian subcontinent. Thalassemia is a kind of genetic disorder of the blood that is passed from one generation to the other, exemplified by reduced or absent amounts of hemoglobin.
Vikas Urkude +3 more
doaj
Türk Biyokimya Dergisiβ-Thalassemias, caused by mutations in HBB, are hereditary blood disorders that impose a significant global health burden. Detecting these mutations through accurate genetic analysis is essential. This study aimed to create a panel of cell type reference
Ren Baoyan +7 more
doaj +1 more source
Hb SKMC and an unprecedented γδβ-thalassemia: first report from Iraq
HematologyBackground Thalassemias are genetic disorders of globin chain synthesis. In Iraq, β-thalassemia is more prevalent than α-thalassemia. This study identifies two unpredicted globin gene mutations, a rare α-globin gene mutation (Hb SKMC) and a novel γδβ ...
Rawand P. Shamoon +6 more
doaj +1 more source
Exploring Affordable Curative Therapy for Sickle Cell Disease in Africa: A Comprehensive Overview
American Journal of Hematology, Volume 101, Issue S1, Page 56-74, April 2026.ABSTRACT The practical aspects of developing curative treatments for sickle cell disease (SCD) in Africa, such as gene therapy and hematopoietic stem cell transplantation, involve strengthening healthcare infrastructure, training healthcare professionals, establishing regional treatment centers, and creating national SCD programs.
Adetola A. Kassim +2 more
wiley +1 more source