Results 1 to 10 of about 63,898 (235)
The Lancet, 2004 Despite its history as a human teratogen, thalidomide is emerging as a treatment for cancer and inflammatory diseases. Although the evolution of its clinical application could not have been predicted from the tragedy associated with its misuse in the past, its history serves as a lesson in drug development that underscores the need to understand the ...
Franks, Michael E. +2 more
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Journal of Pain and Symptom Management, 2011 Thalidomide is responsible for the biggest medical disaster in history, causing severe birth defects in more than 10,000 children, globally, between 1957 and 1962. Understanding how thalidomide caused birth defects has remained a challenge for many years.
Eric E, Prommer +3 more
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Immunomodulation by thalidomide and thalidomide analogues [PDF]
Annals of the Rheumatic Diseases, 1999 Tumour necrosis factor α (TNFα), a key cytokine involved in the host immune response, also contributes to the pathogenesis of both infectious and autoimmune diseases. To ameliorate the pathology resulting from TNFα in these clinical settings, strategies for the inhibition of this cytokine have been developed.
Gilla Kaplan, Laura G. Corral
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Thalidomide and neurotrophism [PDF]
Skeletal Radiology, 2018 Following the thalidomide disaster (1958-62), Henkel and Willert analysed the pattern of dysmelia in the long bones (J Bone Joint Surg Br. 51:399-414, 1969) and the extremities, Willert and Henkel (Z Orthop Ihre Grenzgeb. 107:663-75, 1970). Willert's material from deformed extremities is re-examined here asking "How does thalidomide reduce the skeleton?
Judith R. Soper +4 more
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Thalidomide-induced Teratogenesis : History and Mechanisms [PDF]
, 2015 Peer reviewedPublisher ...
Arlen RR +13 more
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, 2018 A transcription factor called SALL4 could be the missing link between thalidomide and the limb defects caused by the ...
Borozdin +12 more
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Intracranial tuberculous mass lesions treated with thalidomide in an immunocompetent child from a low tuberculosis endemic country: A case report [PDF]
, 2018 Rationale: Tuberculous meningitis is a highly morbid, often fatal disease. Patient concern: We describe a case of an Italian child. Diagnoses: we diagnosed early a Tuberculous meningitis complicated by the occurrence of hydrocephalus, stroke, and ...
Ajassa, Camilla +8 more
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Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects [PDF]
, 2002 The anti-tumour effects of thalidomide have been associated with its anti-angiogenic properties. Second generation thalidomide analogues are distinct compounds with enhanced therapeutic potential.
Chen, R +7 more
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In Vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems [PDF]
, 2016 This study was supported by a Wellcome Trust-NIH PhD Studentship to SB, WDF and NV. Grant number 098252/Z/12/Z. SB, CHC and WDF are supported by the Intramural Research Program, NCI, NIH.
Barnett, Shelby +7 more
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Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease. [PDF]
, 2015 BackgroundParkinson's disease (PD) is one of the most common causes of dementia and motor deficits in the elderly. PD is characterized by the abnormal accumulation of the synaptic protein alpha-synuclein (α-syn) and degeneration of dopaminergic neurons ...
Anderson, Scott +4 more
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