Results 1 to 10 of about 67,878 (296)
Immunomodulation by thalidomide and thalidomide analogues [PDF]
Annals of the Rheumatic Diseases, 1999 Tumour necrosis factor α (TNFα), a key cytokine involved in the host immune response, also contributes to the pathogenesis of both infectious and autoimmune diseases. To ameliorate the pathology resulting from TNFα in these clinical settings, strategies for the inhibition of this cytokine have been developed.
L G, Corral, G, Kaplan
openaire +4 more sources
Thalidomide‐induced teratogenesis: History and mechanisms [PDF]
Birth Defects Research Part C: Embryo Today Reviews, 2015 Peer reviewedPublisher ...
Neil A Vargesson
exaly +3 more sources
Signal Transduction and Targeted Therapy, 2021 Thalidomide induces γ-globin expression in erythroid progenitor cells, but its efficacy on patients with transfusion-dependent β-thalassemia (TDT) remains unclear.
Weida Wang, Guang-Biao Zhou
exaly +2 more sources
Myelodysplastic Syndrome With Complex Chromosomal Karyotype Abnormalities Complicated by Multiple Intestinal Perforations: A Case Report and Literature Review. [PDF]
Case Rep Gastrointest MedBackground Myelodysplastic syndromes (MDSs) are clonal hematopoietic disorders often associated with cytogenetic abnormalities, among which trisomy 8 is one of the most common abnormalities. Trisomy 8 is linked to autoimmune manifestations, including Behçet‐like disease, especially with gastrointestinal involvement.
Niu ZY +5 more
europepmc +2 more sources
The Lancet, 2004 Despite its history as a human teratogen, thalidomide is emerging as a treatment for cancer and inflammatory diseases. Although the evolution of its clinical application could not have been predicted from the tragedy associated with its misuse in the past, its history serves as a lesson in drug development that underscores the need to understand the ...
Michael E, Franks +2 more
+7 more sources
Khyber Medical University JournalOBJECTIVE: To identify the effectiveness and safety of thalidomide in transfusion-dependent beta Thalassemia Major (TDBTM) patients. METHODS: A comprehensive search of PubMed, Cochrane Library, and Embase was conducted between January 01, 2014, and ...
Tahira Atta +4 more
doaj +3 more sources
EBV+ and Kaposi's Sarcoma Herpesvirus-Associated Multicentric Castleman Disease in a Patient With HIV Infection: A Case Report. [PDF]
Case Rep Infect DisMulticentric Castleman disease is a rare proliferative disease of lymphoid tissue. It has rarely been reported in Asian countries, particularly in HIV‐positive patients. Here, we report a case of Kaposi’s sarcoma herpesvirus‐associated Multicentric Castleman disease (KSHV‐MCD).
Huang MY +5 more
europepmc +2 more sources
Biochemistry and Biophysics Reports, 2021 Although thalidomide is highly teratogenic, it has been prescribed for treating multiple myeloma and Hansen's disease. However, its mechanism of action is not fully understood.
Maho Shimizu +6 more
doaj +1 more source
Frontiers in Physiology, 2021 Peritoneal angiogenesis is the key pathophysiological factor that limits peritoneal ultrafiltration during peritoneal dialysis (PD) in uremic patients.
Nan Zhu +8 more
doaj +1 more source
Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs
Molecules, 2020 Due to its antiangiogenic and anti-immunomodulatory activity, thalidomide continues to be of clinical interest despite its teratogenic actions, and efforts to synthesize safer, clinically active thalidomide analogs are continually underway. In this study,
Megan L. Peach +12 more
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