Results 21 to 30 of about 63,898 (235)

Thalidomide attenuates nitric oxide mediated angiogenesis by blocking migration of endothelial cells

BMC Cell Biology, 2006
Background Thalidomide is an immunomodulatory agent, which arrests angiogenesis. The mechanism of anti-angiogenic activity of thalidomide is not fully understood.
Indhumathy M, Rajaram Megha, Kolluru Gopi, Tamilarasan KP, Saranya R, Chatterjee Suvro   +5 more
doaj   +1 more source

Treatment outcome of thalidomide based regimens in newly diagnosed and relapsed/refractory non-transplant multiple myeloma patients: a single center experience from Thailand

Journal of Hematology & Oncology, 2010
Background Thalidomide based regimen is an effective and well tolerated therapy in multiple myeloma (MM) patients, however, there were a small number of studies written about the results of thalidomide therapy in non-transplant MM patients.
Aungchaisuksiri Pantep, Ungkanont Artit, Chuncharunee Suporn, Atichartakarn Vichai, Sorakhunpipitkul Ladda, Niparuck Pimjai, Puavilai Teeraya, Jootar Saengsuree   +7 more
doaj   +1 more source

High-dose thalidomide increases the risk of peripheral neuropathy in the treatment of ankylosing spondylitis

Neural Regeneration Research, 2015
Thalidomide is an effective drug for the treatment of ankylosing spondylitis but might induce peripheral neuropathy. This major adverse reaction has attracted much concern.
Hong-xia Xue, Wen-yi Fu, Hua-dong Cui, Li-li Yang, Ning Zhang, Li-juan Zhao   +5 more
doaj   +1 more source

Thalidomide-induced sinus bradycardia in Crohn’s disease: case report and literature review

Journal of International Medical Research, 2019
Thalidomide is effective in inducing and maintaining clinical remission, as well as mucosal healing, in patients with refractory Crohn’s disease (CD).
Menghui Liu, Xiaoqing Lin, Lichun Wang, Yao He, Minhu Chen, Ren Mao   +5 more
doaj   +1 more source

Arterial dysgenesis and limb defects : Clinical and experimental examples [PDF]

, 2017
Acknowledgements This article is dedicated to Dr David S. Packard Jr. With thanks to Dr John DeSesso, Dr Lewis B. Holmes, Dr Mark Levinsohn, Dr David S.
Hootnick, David R., Vargesson, Neil
core   +1 more source

CUL5 is required for thalidomide-dependent inhibition of cellular proliferation. [PDF]

PLoS ONE, 2018
Angiogenesis is essential for cancer metastasis, thus the discovery and characterization of molecules that inhibit this process is important. Thalidomide is a teratogenic drug which is known to inhibit angiogenesis and effectively inhibit cancer ...
Bryan Kunkler, Daniel Salamango, Zachary J DeBruine, Caitlin Ploch, Shirley Dean, David Grossens, Michael P Hledin, Gabriel A Marquez, Julie Madden, Abigayle Schnell, Michael Short, Maria A Burnatowska-Hledin   +11 more
doaj   +1 more source

Replacing the phthalimide core in thalidomide with benzotriazole

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The advent of proteolysis-targeting chimaeras (PROTACs) mandates that new ligands for the recruitment of E3 ligases are discovered. The traditional immunomodulatory drugs (IMiDs) such as thalidomide and its analogues (all based on the phthalimide ...
Mikhail Krasavin, Andrey Bubyrev, Alexander Kazantsev, Christopher Heim, Samuel Maiwald, Daniil Zhukovsky, Dmitry Dar’in, Marcus D. Hartmann, Alexander Bunev   +8 more
doaj   +1 more source

Molecular Mechanisms of the Teratogenic Effects of Thalidomide

Pharmaceuticals, 2020
Thalidomide was sold worldwide as a sedative over 60 years ago, but it was quickly withdrawn from the market due to its teratogenic effects. Thalidomide was later found to have therapeutic effects in several diseases, although the molecular mechanisms ...
Tomoko Asatsuma-Okumura, Takumi Ito, Hiroshi Handa   +2 more
doaj   +1 more source

Thalidomide decreases gelatinase production by malignant B lymphoid cell lines through disruption of multiple integrin-mediated signaling pathways

Haematologica, 2010
Background Thalidomide and its analogs are effective agents in the treatment of multiple myeloma. Since gelatinases (matrix metalloproteinases-2 and -9) play a crucial role in tumor progression, we explored the effect of thalidomide on gelatinase ...
Marta Segarra, Ester Lozano, Marc Corbera-Bellalta, Carme Vilardell, Maria-Teresa Cibeira, Jordi Esparza, Nora Izco, Joan Bladé, Maria C. Cid   +8 more
doaj   +1 more source

SAFETY AND EFFICACY OF THALIDOMIDE IN TRANSFUSION-DEPENDENT β-THALASSEMIA: A SYSTEMATIC REVIEW AND META-ANALYSIS

Khyber Medical University Journal, 2022
OBJECTIVE: The current meta-analysis was carried out to identify the efficacy and safety of thalidomide in transfusion-dependent β-thalassemia (TDT) patients. METHODS: Six databases: PubMed, EMBASE, Scopus, Cochrane Library, EBSCOhost, and MEDLINE were
Zahid Ali, Mohammad Ismail, Muhammad Tariq Masood Khan, Inayat Ur Rehman   +3 more
doaj   +1 more source