Results 21 to 30 of about 67,878 (296)
Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects [PDF]
, 2002 The anti-tumour effects of thalidomide have been associated with its anti-angiogenic properties. Second generation thalidomide analogues are distinct compounds with enhanced therapeutic potential.
Chen, R +7 more
core +2 more sources
Thalidomide-induced sinus bradycardia in Crohn’s disease: case report and literature review
Journal of International Medical Research, 2019 Thalidomide is effective in inducing and maintaining clinical remission, as well as mucosal healing, in patients with refractory Crohn’s disease (CD).
Menghui Liu +5 more
doaj +1 more source
In Vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems [PDF]
, 2016 This study was supported by a Wellcome Trust-NIH PhD Studentship to SB, WDF and NV. Grant number 098252/Z/12/Z. SB, CHC and WDF are supported by the Intramural Research Program, NCI, NIH.
Barnett, Shelby +7 more
core +1 more source
CUL5 is required for thalidomide-dependent inhibition of cellular proliferation. [PDF]
PLoS ONE, 2018 Angiogenesis is essential for cancer metastasis, thus the discovery and characterization of molecules that inhibit this process is important. Thalidomide is a teratogenic drug which is known to inhibit angiogenesis and effectively inhibit cancer ...
Bryan Kunkler +11 more
doaj +1 more source
Replacing the phthalimide core in thalidomide with benzotriazole
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 The advent of proteolysis-targeting chimaeras (PROTACs) mandates that new ligands for the recruitment of E3 ligases are discovered. The traditional immunomodulatory drugs (IMiDs) such as thalidomide and its analogues (all based on the phthalimide ...
Mikhail Krasavin +8 more
doaj +1 more source
Haematologica, 2010 Background Thalidomide and its analogs are effective agents in the treatment of multiple myeloma. Since gelatinases (matrix metalloproteinases-2 and -9) play a crucial role in tumor progression, we explored the effect of thalidomide on gelatinase ...
Marta Segarra +8 more
doaj +1 more source
Khyber Medical University Journal, 2022 OBJECTIVE: The current meta-analysis was carried out to identify the efficacy and safety of thalidomide in transfusion-dependent β-thalassemia (TDT) patients. METHODS: Six databases: PubMed, EMBASE, Scopus, Cochrane Library, EBSCOhost, and MEDLINE were
Zahid Ali +3 more
doaj +1 more source
Pancreatic cancer cachexia: a review of mechanisms and therapeutics. [PDF]
, 2014 Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately, its treatment is complex and remains a challenge.
Andrew Eugene Hendifar +8 more
core +2 more sources
EBioMedicine, 2017 Trial Design: Open-label, randomised, controlled, pilot proof-of-concept clinical trial. Methods: Participants: Antiretroviral naïve adult males with CD4 count ≥350 cells/mm3. Interventions: Patients were randomised to receive thalidomide 200 mg QD for 3
Tânia R.C. Vergara +11 more
doaj +1 more source
Veterinary Sciences, 2020 Hemangiosarcomas (HSA) are common neoplasms of dogs that often metastasize and are typically fatal. Recently it was demonstrated that thalidomide extends the survival time of dogs with HSA, potentially due to thalidomide-induced inhibition of vascular ...
Jonathan P. Bray, John S. Munday
doaj +1 more source