Results 101 to 110 of about 30,219 (216)

The Need for Improved Public Transparency in the Era of Due Diligence Regulations

Regulation &Governance, EarlyView.
ABSTRACT To address environmental and human rights issues in global commodity supply chains, governments increasingly require information from companies on their sourcing, as part of due‐diligence regulations (DDRs). This shift towards accountability to the regulator rather than to the public calls into question the role left for public transparency ...
Valentin Guye, Patrick Meyfroidt, Erasmus zu Ermgassen   +2 more
wiley   +1 more source

Low‐dose X‐ray radiation induces an adaptive response: A potential countermeasure to galactic cosmic radiation exposure

Experimental Physiology, EarlyView.
Abstract Space exploration involves many dangers including galactic cosmic radiation (GCR). This class of radiation includes high‐energy protons and heavy ionizing ions. NASA has defined GCR as a carcinogenic risk for long‐duration space missions. To date, no clear strategy has been developed to counter chronic GCR exposure.
Siena Edwards, Jessica Adams, Anastasia Tchernikov, John G. Edwards   +3 more
wiley   +1 more source

Ageing does not impair motor neuron adaptations: comparable motor unit responses to strength training in young and older adults

The Journal of Physiology, EarlyView.
Abstract figure legend Ageing is associated with reduced motor neuron excitability and lower motor unit (MU) discharge rates, contributing to impaired voluntary force production. Using high‐density surface EMG and longitudinal motor unit tracking, we show that 4 weeks of isometric strength training increases discharge rates and estimates of persistent ...
Andrea Casolo, Stefanie Del Vecchio, Benjamin I. Goodlich, Bastian Schrader, Stefano Nuccio, Edoardo Lecce, Ilenia Bazzucchi, Luca Angius, Francesco Felici, Joachim Schrader, Dario Farina, Alessandro Del Vecchio   +11 more
wiley   +1 more source

Results and Exploratory Biomarker Analyses of a Phase II Study CHANGEABLE: Combination of PD‐1 Inhibitor and Niraparib in GErm‐Line‐mutAted Metastatic Breast Cancer

MedComm, Volume 7, Issue 4, April 2026.
This phase II trial evaluated the efficacy and safety of niraparib combined with HX008 in metastatic breast cancer (MBC) patients with germline DNA damage response (DDR) gene mutations. This chemotherapy‐free regimen demonstrates promising efficacy and a tolerable safety profile in MBC patients with germline DDR mutations, providing a novel therapeutic
Jian Zhang, Yiqun Du, Yanchun Meng, Yizi Jin, Mingxi Lin, Xuchen Shao, Xiaojun Liu, Yuxin Mu, Yun Liu, Zhen Hu   +9 more
wiley   +1 more source

A phase 1 study of berzosertib (M6620, VX‐970) in combination with cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma (ETCTN 9950)

Cancer, Volume 132, Issue 6, 15 March 2026.
ABSTRACT Background Ataxia telangiectasia Rad3‐related (ATR) protein kinase regulates DNA damage response and is essential for tumor cell survival. Preclinically, ATR inhibition can sensitize tumor cells to radiation and chemotherapy. The authors conducted a phase 1 trial of berzosertib, a selective ATR inhibitor, in combination with definitive ...
Aarti Bhatia, Zhengjia Chen, Yuji Zhang, Justine Yang Bruce, Susanne Arnold, Varinder Kaur, Jonathan W. Riess, Moon Fenton, Barbara Burtness, Nabil F. Saba, Harold Tara, Conor E. Steuer, Dong M. Shin, Garrett Wasp, Thomas H. Davis, Malini Patel, John C. Schmitz, Priyanka Bhateja, Virginia Diavolitsis, Dan P. Zandberg, Darrion L. Mitchell, Brian F. Kiesel, Charles Kunos, Steven D. Gore, Michael Carducci, Jan H. Beumer, Taofeek K. Owonikoko   +26 more
wiley   +1 more source

Predicting DNA damage response using synthetic cell painting profiles and experimental analysis. [PDF]

iScience
Seo C, Lim H, Piao Z, Koh YJ, Lee SJ.
europepmc   +1 more source

Biomechanical Analysis Evaluating an Augmentation Technique for Supraspinatus Double-Row Repair With Additional Double-Row Anterior Fixation: "The Double-Double-Row Repair". [PDF]

Orthop J Sports Med
Teel JE, Hollenbeck JFM, Castro RR, Buchalter WH, Kanakamedala AC, Adriani M, Ganokroj P, Dickinson NJ, Jaber A, Millett PJ, Provencher MT.   +10 more
europepmc   +1 more source

Synthetic lethality and DNA damage response targeting in cancer stem cells: a comprehensive review. [PDF]

Discov Oncol
Sayed U, Abdulsahib WK, Jasim IK, Malathi H, Nayak PP, Alex Anand D, Mukherjee G, Sinha A, Eshkaraev S.   +8 more
europepmc   +1 more source

Next Generation DNA Damage Response Inhibitors: Harnessing Nanocarriers and Tumor Microenvironment for Precision Cancer Therapy. [PDF]

Oncol Res
Solomon AD, Vats HK, Chowdhary S, Kanoujiya SN, Prakash A, Sultana H, Mohanty S, Day BW, Pant T.   +8 more
europepmc   +1 more source

A WYL transcriptional regulator activates the DNA damage response pathway in Acinetobacter species. [PDF]

Nucleic Acids Res
Ellison TJ, Smith TA, Vennapusa N, Hummels KR, Ellison CK.   +4 more
europepmc   +1 more source