Results 111 to 120 of about 149,069 (251)

Advancing cancer therapy: new frontiers in targeting DNA damage response

Frontiers in Pharmacology
Genomic instability is a core characteristic of cancer, often stemming from defects in DNA damage response (DDR) or increased replication stress. DDR defects can lead to significant genetic alterations, including changes in gene copy numbers, gene ...
Jiekun Qian, Jiekun Qian, Guoliang Liao, Guoliang Liao, Maohui Chen, Maohui Chen, Ren-Wang Peng, Xin Yan, Jianting Du, Jianting Du, Renjie Huang, Renjie Huang, Maojie Pan, Maojie Pan, Yuxing Lin, Yuxing Lin, Xian Gong, Xian Gong, Guobing Xu, Guobing Xu, Bin Zheng, Bin Zheng, Chun Chen, Chun Chen, Zhang Yang, Zhang Yang   +25 more
doaj   +1 more source

Why Human Papillomaviruses Activate the DNA Damage Response (DDR) and How Cellular and Viral Replication Persists in the Presence of DDR Signaling

Viruses, 2017
Human papillomaviruses (HPV) require the activation of the DNA damage response (DDR) in order to undergo a successful life cycle. This activation presents a challenge for the virus and the infected cell: how does viral and host replication proceed in the
Molly L. Bristol, Dipon Das, Iain M. Morgan   +2 more
doaj   +1 more source

The Complexity of Order Type Isomorphism

, 2013
The order type of a point set in $R^d$ maps each $(d{+}1)$-tuple of points to its orientation (e.g., clockwise or counterclockwise in $R^2$). Two point sets $X$ and $Y$ have the same order type if there exists a mapping $f$ from $X$ to $Y$ for which ...
Aloupis, Greg, Iacono, John, Langerman, Stefan, Wuhrer, Stefanie S., Özkan, Özgür   +4 more
core   +1 more source

The clashing of in situ and pre‐cast technologies—Western trends and local traditions in concrete engineering shaping shell construction in 20th‐century Hungary

Structural Concrete, EarlyView.
Abstract After a blossoming pre‐World War II (WWII) period, the concrete construction industry in then‐socialist Hungary existed in a relative isolation from the Western World during the mid‐20th century. In this paper, we focus on the body of work of one of the then newly established state‐owned design offices, IPARTERV, to show how the isolation ...
Orsolya Gáspár, Péter Haba
wiley   +1 more source

Signal‐to‐noise and spatial resolution in in‐line imaging. 3. Optimization using a simple model

Journal of Synchrotron Radiation, EarlyView.
Geometrical magnification and X‐ray energy are optimized with respect to spatial resolution, contrast, noise, radiation dose and other image quality characteristics. The optimization is performed using a simple theoretical model of a homogeneous edge feature embedded in a bulk uniform sample, and the resulting generic analytical expressions for image ...
Timur E. Gureyev, David M. Paganin, Harry M. Quiney   +2 more
wiley   +1 more source

Aspects of Radical Gay Liberation Theory in West Germany's Tuntenstreit, 1973–1975

Gender &History, EarlyView.
ABSTRACT This article examines in depth the theoretical positions of the Tuntenstreit – a major theoretical dispute within the radical West German gay liberation movement in the 1970s. By working through archival material as well as the dispute's fundamental texts, it renders visible its often‐neglected underlying theoretical motifs and, consequently ...
Hauke Branding
wiley   +1 more source

Induction of Stress Granule Assembly is Essential for the Orchestration of DNA Damage Response [PDF]

, 2008
DNA damage provokes several responses including DNA repair, cell cycle regulation and apoptosis that collectively represent the DNA damage response (DDR).
Nicole S. Verkaik, Stephan Persengiev
core   +1 more source

Fixed points and their stability in the functional renormalization group of random field models

, 2013
We consider the zero-temperature fixed points controlling the critical behavior of the $d$-dimensional random-field Ising, and more generally $O(N)$, models.
Baczyk, Maxime, Balog, Ivan, Tarjus, Gilles, Tissier, Matthieu   +3 more
core   +1 more source

The Wind of Change: Mapping Wind Energy Growth and Multi‐Species Vulnerability in Sardinia, Mediterranean

Animal Conservation, EarlyView.
The rapid expansion of wind energy across the Mediterranean region calls for more advanced tools to assess and mitigate its impacts on biodiversity. In this study, we present an innovative approach combining 13‐year satellite imagery analysis and ecological modelling, to assess the spatiotemporal overlap between wind energy development and habitat ...
Chiara Costantino, Jacopo Cerri, Ilaria Fozzi, Davide De Rosa, Fiammetta Berlinguer   +4 more
wiley   +1 more source

Anti-tumor effects of the eIF4A inhibitor didesmethylrocaglamide and its derivatives in human and canine osteosarcomas

Scientific Reports
Inhibition of translation initiation using eIF4A inhibitors like (−)-didesmethylrocaglamide [(−)-DDR] and (−)-rocaglamide [(−)-Roc] is a potential cancer treatment strategy as they simultaneously diminish multiple oncogenic drivers.
Janet L. Oblinger, Jack Wang, Georgia D. Wetherell, Garima Agarwal, Tyler A. Wilson, Nicole R. Benson, Joelle M. Fenger, James R. Fuchs, A. Douglas Kinghorn, Long-Sheng Chang   +9 more
doaj   +1 more source