Results 121 to 130 of about 149,069 (251)
Seneca Valley virus infection exploits DNA damage response to facilitate viral replication
Journal of VirologySeneca Valley virus (SVV) is an emerging pathogen that causes severe vesicular diseases in swine, posing a significant threat to the global pork industry.
Jiangwei Song +7 more
doaj +1 more source
Extracellular vesicles transfer nuclear Abl-dependent and radiation-induced miR-34c into unirradiated cells to cause bystander effects. [PDF]
, 2018 Ionizing radiation (IR) not only activates DNA damage response (DDR) in irradiated cells but also induces bystander effects (BE) in cells not directly targeted by radiation.
Chan, Josolyn +3 more
core
Alimentary Pharmacology &Therapeutics, EarlyView.Nationwide implementation of double reflex testing for hepatitis delta in Spain markedly increased anti‐HDV and HDV viral load testing between 2022 and 2024, enabling national seroprevalence estimates. Despite this progress, substantial regional heterogeneity persists, highlighting the need for standardised reflex diagnostic protocols.
Ana Alberola +95 more
wiley +1 more source
Organ Donation After Medical Aid in Dying: An Ethical Overview
Bioethics, EarlyView.ABSTRACT Organ Donation after Medical Aid in Dying (OD‐MAiD) is currently practised in four countries: Belgium, Canada, the Netherlands, and Spain. While OD‐MAiD shares some similarities with MAiD (absent the possibility of organ donation) and with standard organ donation protocols, the combination of OD and MAiD involves unique circumstances that ...
David Rodríguez‐Arias +5 more
wiley +1 more source
DDRed in Liberia: Youth Remarginalisation or Reintegration? [PDF]
This report questions mainstream approaches to the reintegration of youthful ex-combatants. In Liberia, the disarmament and demobilisation was implemented quite effectively, but several questions can be asked about the components of reintegration and ...
Ingunn Bjørkhaug, Morten Bøås
core
Poly(ADP-Ribosyl)ation affects stabilization of CHE-1 protein in response to DNA damage [PDF]
, 2011 Post-translation modifications play a crucial role in coordinating the cellular response to DNA damage. Double strand DNA breaks (DSBs) trigger the activation of ATM and Chk2 kinases, which represent the primary transducers in the signalling cascade ...
BACALINI, MARIA GIULIA
core
A11 Peptide Enhances Radiosensitivity by Degrading EphA2 in Nasopharyngeal Carcinoma
Cancer Science, EarlyView.In EphA2‐high‐expressing nasopharyngeal carcinoma cells, radiation triggers RSK‐dependent phosphorylation of EphA2 at Ser897, which in turn activates AKT and promote radioresistance. The A11 peptide breaks this signaling cascade by degrading EphA2 and blocking its S897 phosphorylation, thereby markedly enhancing radiosensitivity.
Ming Zhang +5 more
wiley +1 more source
Cancer Science, EarlyView.We uncovered pronounced and heterogeneous tumor senescence in EOCRC, independent of age. By integrating multi‐omics and single‐cell analyses, we developed EO‐Senscore, a prognostic tool that stratifies patients by immune phenotype and therapy response, enabling precision treatment using immunotherapy or senolytic agents. ABSTRACT Early‐onset colorectal
Du Cai +11 more
wiley +1 more source
Cancer Science, EarlyView.Using integrated spatial pathomics and transcriptomics, we show that neoadjuvant therapy (NAT) in pancreatic ductal adenocarcinoma (PDAC) induces substantial tumor microenvironment remodeling that is not captured by tumor regression grading (TRG) alone.
Xiaofei Zhang +16 more
wiley +1 more source
The FEBS Journal, EarlyView.CellMorph is a groundbreaking tool that allows researchers to analyze multiple features from single cells, including cell size and shape, cytosolic staining and subcellular texture, nuclear staining, and morphometry. By evaluating images from both bright‐field and fluorescence microscopy, it also tracks changes in living cells during key processes such
Henrique Quaiato de Oliveira +16 more
wiley +1 more source