Results 131 to 140 of about 149,069 (251)

Zeocin-induced DNA damage response in barley and its dependence on ATR

Scientific Reports
DNA damage response (DDR) is an essential mechanism by which living organisms maintain their genomic stability. In plants, DDR is important also for normal growth and yield.
Jovanka Vladejić, Martin Kovacik, Jana Zwyrtková, Miriam Szurman-Zubrzycka, Jaroslav Doležel, Ales Pecinka   +5 more
doaj   +1 more source

DNA damage response deficiency enhances neuroblastoma progression and sensitivity to combination PARP and ATR inhibition

Cell Reports
Summary: Sequencing of neuroblastoma (NB) tumors has revealed genetic alterations in genes involved in DNA damage response (DDR) pathways. However, roles for specific alterations of DDR genes in pediatric solid tumors remain poorly understood. To address
Madeline N. Hayes, Sarah Cohen-Gogo, Lynn Kee, Xueting Xiong, Alex Weiss, Mehdi Layeghifard, Yagnesh Ladumor, Ivette Valencia-Sama, Anisha Rajaselvam, David R. Kaplan, Anita Villani, Adam Shlien, Daniel A. Morgenstern, Meredith S. Irwin   +13 more
doaj   +1 more source

Comprehensive Evaluation of OpenCL-based Convolutional Neural Network Accelerators in Xilinx and Altera FPGAs [PDF]

, 2016
Deep learning has significantly advanced the state of the art in artificial intelligence, gaining wide popularity from both industry and academia.
Kadetotad, Deepak, Kim, Minkyu, Linares Barranco, Alejandro, Ríos Navarro, José Antonio, Seo, Jae-Sun, Tapiador Morales, Ricardo   +5 more
core  

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

EIGENSINN AND DOMINATION IN LIBERAL AND ILLIBERAL SOCIETIES

History and Theory, EarlyView.
ABSTRACT This article is a posthumously published text that was written by Alf Lüdtke and Alexandra Oeser but was left unfinished when Lüdtke died in February 2019. It examines two central notions—and their articulations—that Lüdtke and Oeser use differently in their work: domination and Eigensinn. On domination, it focuses on perspectives of Max Weber'
Alf Lüdtke, Alexandra Oeser
wiley   +1 more source

D-heads, domain restriction, and variation: from Greek and Basque to St'at'imcets Salish [PDF]

, 2011
In joint work (Giannakidou 2004, Etxeberria 2005, Etxeberria and Giannakidou 2010), we argue that one of the functions a D head can perform in language is to provide domain restriction. For this, we propose a new mode of composition for D--DDR.
Etxeberria, Urtzi
core  

The Information Content of Operational Effectiveness

Journal of Business Finance &Accounting, EarlyView.
ABSTRACT We address whether and why a firm's operational effectiveness, OpEff$\textit{OpEff}$, has information content for investors and what role that information plays in the price discovery process at quarterly earnings announcements. We measure OpEff$\textit{OpEff}$ using the cash conversion cycle (CCC) multiplied by −1, such that higher OpEff ...
Mary E. Barth, Jonathan Berkovitch, Doron Israeli   +2 more
wiley   +1 more source

Constitutive nitric oxide synthases deficiency impairs cyclobutane pyrimidine dimer repair following solar UV exposure in cells and mice

Photochemistry and Photobiology, EarlyView.
Proposed model for the dual role of cNOS in DNA damage and repair upon UV radiation. Abstract Solar ultraviolet (sUV) radiation is a major environmental factor that induces DNA damage, promoting skin aging and carcinogenesis. The formation of cyclobutane pyrimidine dimers (CPDs) is one of the most prevalent forms of UV‐induced DNA lesions, playing a ...
Veronica Bahamondes Lorca, Yuxi Zhou, Christina Athans, Hailey Payne, Madison Wright, Zeinab Feyyaz, Lingying Tong, Dawn L. Sammons, Shiyong Wu   +8 more
wiley   +1 more source

Root surface biomodification in periodontal therapy: Biological rationale and clinical applications

Periodontology 2000, EarlyView.
Abstract Regenerative periodontal therapy aims to form new cementum, periodontal ligament, and alveolar bone, all sealed by gingival tissue. The root surface acts as the wound margin during this regeneration process. Root surface biomodification (root conditioning/root decontamination), therefore, seems instrumental in promoting surface decontamination
Muhammad H. A. Saleh, Debora R. Dias, Andrea Ravida, Hom‐Lay Wang   +3 more
wiley   +1 more source

Due Diligence Regulation and Sustainability Governance in Value Chains: Lessons From the South African Wine Sector

Regulation &Governance, EarlyView.
ABSTRACT A recent raft of due diligence regulation (DDR) addressing social and environmental conditions in global value chains (GVCs) has spread across the UK and Europe. An emerging literature on DDR highlights the politics of its formation. Yet, we know little about how existing sustainability governance along GVCs interacts with DDR or the wider ...
Matthew Alford, Reena das Nair, Margareet Visser, Stefano Ponte, Shingie Chisoro   +4 more
wiley   +1 more source