Results 151 to 160 of about 150,892 (276)

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Integrated Molecular Profiling Improves Subtype Classification and Reveals Inherited Susceptibility in Medulloblastoma: Insights From a Real‐World Cohort

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Medulloblastoma (MB) is a heterogeneous pediatric brain tumor characterized by distinct molecular subtypes. Although genomics and transcriptomics have improved subtype classification and informed targeted therapies, the clinical utility of integrated molecular profiling in real‐world settings remains incompletely defined. Methods We
Jiwei Song, Tiantian Han, Siqi Chen, Dongsheng Chen, Ziying Liu   +4 more
wiley   +1 more source

Non-coding RNA regulation of the radiation-induced DNA damage response and its translational relevance. [PDF]

Discov Oncol
Wilson C, Gaur A, Swaroop P, Vishwas V, Kumar S, Ghose S, Chopra A, Sharma DN, Bakhshi S, Sharawat SK.   +9 more
europepmc   +1 more source

Clinical Significance of Biomarkers in Oropharyngeal Squamous Cell Carcinoma: Recurrence Prediction and Treatment Response

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Oropharyngeal squamous cell carcinoma (OPSCC) accounts for a substantial proportion of head and neck cancers, with a rising incidence largely driven by human papillomavirus (HPV) infection. Despite advances in multimodal treatment, disease recurrence remains common and limits long‐term survival, highlighting the need for reliable ...
Yunxia Chen, Wenyu Zhang, Xiang Gao, Kongling Xing, Yijing Ren, Jinyu Hu, Zhihao Xie, Ping Zhou   +7 more
wiley   +1 more source

Combined Inhibition of ATR and Ribonucleotide Reductase Induces Synergistic Antineoplastic Activity in Osteosarcoma Cells

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Osteosarcoma is the most common bone cancer in children and young adults. Its prognosis has not improved significantly since the introduction of the chemotherapy regimen established about 40 years ago, highlighting the need for new therapeutic strategies.
Natalie Aderhold, Lisa Immesberger, Sabine Becker, Till Milde, Bernd Gruhn, Jürgen Sonnemann   +5 more
wiley   +1 more source

The DNA damage response pathway is required for multiciliated cell differentiation. [PDF]

Curr Biol
Jewett CE, Holland AJ, Pearson CG.
europepmc   +1 more source

Resveratrol for Cancer Radio‐Sensitization: Ready for Prime Time or Future Perspective

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Resveratrol exerts antioxidant and anti‐inflammatory effects by reducing reactive oxygen species and suppressing NF‐κB and JAK/STAT signaling pathways. It modulates metabolic signaling through AMPK‐dependent inhibition of mTOR, influencing cell survival and inflammatory responses.
Maryam Fallah, Ali Soleimani, Ali Nouri, Melika Fallah, Alireza Haghighi, Ahmad Reza Dehpour, Abolfazl Zendehdel, Soraiya Ebrahimpour‐Koujan   +7 more
wiley   +1 more source

Predicting DNA damage response using synthetic cell painting profiles and experimental analysis. [PDF]

iScience
Seo C, Lim H, Piao Z, Koh YJ, Lee SJ.
europepmc   +1 more source

Targeting Tumor Stroma: Current Challenges and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang, Haofan Hu, Weifeng Zeng, Lu Qin, Xiaoping Chen, Zhibin Liao, Furong Liu, Zhanguo Zhang   +7 more
wiley   +1 more source

Metabolic drivers of genome instability in cancer: mechanisms and therapeutic opportunities. [PDF]

Exp Hematol Oncol
Wang YS, Qian LH, Liu CC, Yu KD.
europepmc   +1 more source