Results 171 to 180 of about 150,892 (276)

Re‐Evaluating Hot Mitochondria: Too Slow to Cool

open access: yesActa Physiologica, Volume 242, Issue 5, May 2026.
ABSTRACT Aim Mito Thermo Yellow (MTY) is a mitochondrially targeted fluorophore that shows marked fluorescence quenching with increasing temperature, allowing for interrogating temperature dynamics in the mitochondria of live cells. Here we re‐evaluate published MTY fluorescence responses used to argue in favor of the ‘hot mitochondria’ concept; the ...
Jason R. Treberg, Ryan J. Mailloux
wiley   +1 more source

Enhancing fundus image analysis for diabetic retinopathy using CheXNet with CBAM and Grad-CAM visualization. [PDF]

open access: yesFront Med (Lausanne)
Al-Dolat W   +10 more
europepmc   +1 more source

Nationwide Implementation of Double Reflex Testing for Hepatitis Delta in Spain: Results From the Retrospective Phase of the Spain‐DDR Study

open access: yesAlimentary Pharmacology &Therapeutics, Volume 63, Issue 10, Page 1390-1397, May 2026.
Nationwide implementation of double reflex testing for hepatitis delta in Spain markedly increased anti‐HDV and HDV viral load testing between 2022 and 2024, enabling national seroprevalence estimates. Despite this progress, substantial regional heterogeneity persists, highlighting the need for standardised reflex diagnostic protocols.
Ana Alberola   +95 more
wiley   +1 more source

Targeting PRMTs Creates Vulnerability of DNA Double‐Stand Break Repair Pathways, and Potentiates Chemotherapy Efficacy in TNBC

open access: yesCancer Science, Volume 117, Issue 5, Page 1273-1285, May 2026.
Our work makes the proof of concept that there is a clinical benefit to target both PRMT1 and PRMT5 to maximize the anti‐tumoral effect of chemotherapy in triple negative breast cancer. ABSTRACT Patients with triple‐negative breast cancer (ER−, PR−, and HER2−) are routinely treated with chemotherapies that induce DNA damage.
Charlène Thiebaut   +13 more
wiley   +1 more source

Effect of the Buccal Gap Width on Alveolar Process Reduction Following Immediate Implant Placement: A Retrospective CBCT Study

open access: yesClinical Oral Implants Research, Volume 37, Issue 5, Page 630-642, May 2026.
ABSTRACT Objectives To evaluate the effect of the width of the buccal gap on the alveolar process reduction after immediate implant placement (IIP) at maxillary central incisor sites, compared to contralateral pristine tooth sites. Material and Methods Twenty‐eight subjects who were treated with IIP to replace a maxillary central incisor and presented ...
Maurício G. Araújo   +3 more
wiley   +1 more source

Functional Germline DNA Repair Mutations as Predictors of Acute Radiodermatitis in Breast Cancer. [PDF]

open access: yesDiagnostics (Basel)
Cătană A   +7 more
europepmc   +1 more source

SCL15 Promotes Seed Longevity Acquisition in Arabidopsis thaliana by Enhancing Antioxidant and Repair Mechanisms During Maturation

open access: yesPhysiologia Plantarum, Volume 178, Issue 3, May/June 2026.
ABSTRACT To ensure seed longevity and successful germination, orthodox seeds acquire protective and repair mechanisms during the late stage of seed development to counteract the detrimental effects of desiccation and subsequent rehydration, processes often associated with oxidative stress.
Ming‐Jun Gao   +5 more
wiley   +1 more source

A phase 1 study of ASTX727 plus talazoparib in patients with triple‐negative or hormone resistant/HER2‐negative metastatic breast cancer

open access: yesCancer, Volume 132, Issue 8, 15 April 2026.
Abstract Background Poly(adenosine diphosphate ribose) polymerase (PARP) is recruited to DNA damage sites along with epigenetic factors such as DNA methyltransferase 1 (DNMT1). Inhibitors of DNMT modulate reactive oxygen species (ROS)‐cyclic adenosine monophosphate (cAMP)/Protein Kinase A signaling and induce a “BRCAness phenotype” that further ...
Kathy D. Miller   +14 more
wiley   +1 more source

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