Results 171 to 180 of about 150,892 (276)
Re‐Evaluating Hot Mitochondria: Too Slow to Cool
ABSTRACT Aim Mito Thermo Yellow (MTY) is a mitochondrially targeted fluorophore that shows marked fluorescence quenching with increasing temperature, allowing for interrogating temperature dynamics in the mitochondria of live cells. Here we re‐evaluate published MTY fluorescence responses used to argue in favor of the ‘hot mitochondria’ concept; the ...
Jason R. Treberg, Ryan J. Mailloux
wiley +1 more source
Enhancing fundus image analysis for diabetic retinopathy using CheXNet with CBAM and Grad-CAM visualization. [PDF]
Al-Dolat W +10 more
europepmc +1 more source
Nationwide implementation of double reflex testing for hepatitis delta in Spain markedly increased anti‐HDV and HDV viral load testing between 2022 and 2024, enabling national seroprevalence estimates. Despite this progress, substantial regional heterogeneity persists, highlighting the need for standardised reflex diagnostic protocols.
Ana Alberola +95 more
wiley +1 more source
Overcoming acquired doxorubicin resistance of ovarian carcinoma cells by verapamil‑mediated promotion of DNA damage‑driven cytotoxicity. [PDF]
Mukinovic E +7 more
europepmc +1 more source
Our work makes the proof of concept that there is a clinical benefit to target both PRMT1 and PRMT5 to maximize the anti‐tumoral effect of chemotherapy in triple negative breast cancer. ABSTRACT Patients with triple‐negative breast cancer (ER−, PR−, and HER2−) are routinely treated with chemotherapies that induce DNA damage.
Charlène Thiebaut +13 more
wiley +1 more source
ABSTRACT Objectives To evaluate the effect of the width of the buccal gap on the alveolar process reduction after immediate implant placement (IIP) at maxillary central incisor sites, compared to contralateral pristine tooth sites. Material and Methods Twenty‐eight subjects who were treated with IIP to replace a maxillary central incisor and presented ...
Maurício G. Araújo +3 more
wiley +1 more source
Functional Germline DNA Repair Mutations as Predictors of Acute Radiodermatitis in Breast Cancer. [PDF]
Cătană A +7 more
europepmc +1 more source
ABSTRACT To ensure seed longevity and successful germination, orthodox seeds acquire protective and repair mechanisms during the late stage of seed development to counteract the detrimental effects of desiccation and subsequent rehydration, processes often associated with oxidative stress.
Ming‐Jun Gao +5 more
wiley +1 more source
Abstract Background Poly(adenosine diphosphate ribose) polymerase (PARP) is recruited to DNA damage sites along with epigenetic factors such as DNA methyltransferase 1 (DNMT1). Inhibitors of DNMT modulate reactive oxygen species (ROS)‐cyclic adenosine monophosphate (cAMP)/Protein Kinase A signaling and induce a “BRCAness phenotype” that further ...
Kathy D. Miller +14 more
wiley +1 more source

