Results 171 to 180 of about 44,512 (277)

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

Merkel Cell Polyomavirus and DNA Damage Response (DDR): Transcriptional Analysis of DDR Pathways in the Context of Merkel Cell Carcinoma. [PDF]

Cancers (Basel)
Messina S, Mallardo D, Ferlosio A, Festino L, Trojaniello C, Di Trolio R, Ciotti M, Ascierto PA, Pietropaolo V, Passerini S.   +9 more
europepmc   +1 more source

TONSL Promotes Hepatocellular Carcinoma Progression by Inhibiting Apoptosis Through Homologous Recombination Repair

Cancer Science, Volume 117, Issue 7, Page 1852-1866, July 2026.
In hepatocellular carcinoma, the 8q24.3 locus is frequently amplified and is associated with tumor‐specific overexpression of TONSL. TONSL promotes homologous recombination repair through RAD51, limits γH2AX accumulation and apoptosis, supports tumor growth, and its loss increases sensitivity to poly (ADP‐ribose) polymerase (PARP) inhibition.
Akinori Tsujimoto, Hajime Otsu, Takashi Ofuchi, Tomohiko Ikehara, Kosuke Hirose, Shohei Shibuta, Kazuki Omachi, Yu Takahashi, Yuya Ono, Satoshi Higuchi, Takanari Tatsumi, Kiyotaka Hosoda, Qingjiang Hu, Yusuke Yonemura, Takaaki Masuda, Masayuki Sho, Koshi Mimori   +16 more
wiley   +1 more source

Molecular landscape and clinical translation of DNA damage response alterations in solid tumors: A pan-cancer perspective on precision oncology. [PDF]

Neoplasia
Zhu H, Shao J, Wang Y, Gu C, Liu J.
europepmc   +1 more source

Losartan Enhances Radiosensitivity by Reversing Immunosuppressive Tumor Microenvironment Induced by Radiotherapy in TNBC

Cancer Science, Volume 117, Issue 7, Page 1795-1812, July 2026.
Our study demonstrates that the angiotensin receptor blocker losartan enhances the efficacy of radiotherapy in triple‐negative breast cancer by reversing the immunosuppressive tumor microenvironment. Losartan reprograms tumor‐associated macrophages, inhibits myeloid‐derived suppressor cell function, and boosts CD8+ T‐cell activity.
Xu Wang, Cuiwei Liu, Zihan Xia, Ting Hu, Yuting Li, Dan Han, Yunjie Song, Yuxi Ma, Yanxia Zhao   +8 more
wiley   +1 more source

Long-Term PET-Nanoplastic Exposure Alters DNA Damage Response Capacity in BEAS-2B Human Bronchial Epithelial Cells. [PDF]

Int J Mol Sci
Morataya-Reyes M, Villacorta A, Egea R, Martín-Pérez J, Gutiérrez-García J, Pastor S, Marcos R, Hernández A.   +7 more
europepmc   +1 more source

In Silico Drug Repositioning Identifies SYK Kinase Inhibitors as Potential Neuroprotective Agents for Ataxia–Telangiectasia

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
Repositioning of vemurafenib and palbociclib as spleen tyrosine kinase inhibitors for the treatment of neuroinflammation in Ataxia–Telangiectasia. ABSTRACT Ataxia–Telangiectasia (AT) is a rare neurodegenerative disorder characterized by progressive neuronal loss and chronic neuroinflammation.
Alessia Romano, Rocco Buccheri, Chiara Zagni, Antonio Rescifina   +3 more
wiley   +1 more source

Diversity of Factors Associated with Physical Inactivity in Patients with Asthma Based on Activity Intensity. [PDF]

J Clin Med
Murakawa K, Hirano T, Doi K, Fukatsu-Chikumoto A, Yamaji Y, Iwamoto H, Miyamoto S, Higaki N, Amano Y, Anabuki K, Yamane M, Oishi K, Asami-Noyama M, Edakuni N, Kakugawa T, Matsunaga K.   +15 more
europepmc   +1 more source

‘ZWISCHEN DEN ZEILEN’: A CLOSE READING OF STEFANIE‐LAHYA AUKONGO'S NEUROQUEER POETRY

German Life and Letters, Volume 79, Issue 3, Page 365-383, July 2026.
ABSTRACT This article analyses the multimodal poetry of Stefanie‐Lahya Aukongo (b. 1978) through the framework of neuroqueer theory (e.g. Nick Walker, M. Remi Yergeau), showing how her poetic practice exposes and destabilises socially constructed norms of neurotypicality.
Catherine Smale
wiley   +1 more source

Accurate prediction of candidate lncRNAs associated with DNA damage response based on gene expression patterns from graph neural networks. [PDF]

Bioinform Adv
Shah S, Wang L.
europepmc   +1 more source