Results 161 to 170 of about 149,069 (251)

Regulation of R‐Loop Dynamics by Proteins and Long Noncoding RNAs: An Emerging Paradigm for Cancer Treatment

Cancer Science, Volume 117, Issue 2, Page 297-307, February 2026.
R‐loops are three‐stranded nucleic acid structures whose dysregulation leads to genomic instability and cancer progression. This review summarizes the protein and lncRNA machineries that regulate R‐loop dynamics and discusses the therapeutic potential of targeting these pathways in cancer.
Miho M. Suzuki, Keiko Shinjo, Tatsunori Nishimura, Yutaka Kondo   +3 more
wiley   +1 more source

Characteristics of Germline and Somatic Mutations of DNA Repair Genes in Korean Men with Prostate Cancer. [PDF]

World J Mens Health
Lee H, Ho JN, Song SH, Oh JJ, Huh JS, Kim HM, Kim KH, Kim S, Byun SS.   +8 more
europepmc   +1 more source

TGM2 Regulates Radiosensitivity via POGZ‐Mediated Repair of DNA Double‐Strand Breaks in Cervical Cancer

Cancer Science, Volume 117, Issue 2, Page 429-444, February 2026.
The present study revealed for the first time that TGM2 could regulate the radiosensitivity of cervical cancer via POGZ‐mediated DNA DSB repair. Our findings revealed that TGM2 regulates the radiosensitivity of cervical cancer and demonstrated that POGZ serves as a bridge linking TGM2 to the DNA damage repair process, and suggested a novel mechanistic ...
Yunbo Chi, Peng Dong, Ning Zhang, Baocai Liu, Qian Wang, Guanghui Cheng   +5 more
wiley   +1 more source

Editorial: Overcoming resistance in DDR inhibition: new targets and therapeutic strategies. [PDF]

Front Mol Biosci
Tsai CL, Gonçalves AC, Ahmed Z.
europepmc   +1 more source

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, Volume 59, Issue 2, February 2026.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

A legacy of the DDR

, 2021
openaire   +2 more sources

An Integrated Nonclinical and Clinical Risk Assessment of the Effects of Investigational ATRi Tuvusertib on QTc Interval in Patients With Solid Tumors

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Tuvusertib is an investigational, orally administered inhibitor of ATR protein kinase, currently in Phase II clinical development. Here, we present an integrated nonclinical and clinical assessment of the effect of tuvusertib on QTc interval.
Jatinder Kaur Mukker, Timothy A. Yap, Anthony W. Tolcher, Johann S. de Bono, Ruth Plummer, Gary Grosser, Christoph van Amsterdam, Hanno Schieferstein, Han Witjes, Paul Matthias Diderichsen, Axel Krebs‐Brown, Wei Gao, Rainer Strotmann, Zoltan Szucs, Ioannis Gounaris, Karthik Venkatakrishnan   +15 more
wiley   +1 more source

Prevalence and Clinical Associations of Germline DDR Variants in Prostate Cancer: Real-World Evidence from a 122-Patient Turkish Cohort. [PDF]

Genes (Basel)
Akay S, Ozdemir TR, Ozer Kaya O, Degirmenci M, Unal OU.   +4 more
europepmc   +1 more source

Taking the DDR down a Notch [PDF]

Nature Reviews Molecular Cell Biology, 2015
openaire   +1 more source

Two-stage deep learning approach for screening for anterior disk displacement of the temporomandibular joint using orthopantomograms. [PDF]

Sci Rep
Kim JS, Kim T, Ahn YH, Kim HG, Ahn SJ.
europepmc   +1 more source