Results 11 to 20 of about 30,219 (216)
Cells, 2022 Glioblastoma is a highly aggressive, invasive and treatment-resistant tumour. The DNA damage response (DDR) provides tumour cells with enhanced ability to activate cell cycle arrest and repair treatment-induced DNA damage.
Mathew Lozinski +6 more
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DNA Damage Response Evaluation Provides Novel Insights for Personalized Immunotherapy in Glioma
Frontiers in Immunology, 2022 BackgroundDNA damage response (DDR) proficiency is the principal mechanism of temozolomide (TMZ) resistance in glioma. Accumulating evidence has also suggested the determining role of DDR in anticancer immunity.
Mu Chen +12 more
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COP9 signalosome function in the DDR [PDF]
FEBS Letters, 2011 The COP9 signalosome (CSN) is a platform for protein communication in eukaryotic cells. It has an intrinsic metalloprotease that removes the ubiquitin (Ub)‐like protein Nedd8 from cullins. CSN‐mediated deneddylation regulates culling‐RING Ub ligases (CRLs) and controls ubiquitination of proteins involved in DNA damage response (DDR).
Hannß, Ronny, Dubiel, Wolfgang
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Monitoring the Activation of the DNA Damage Response Pathway in a 3D Spheroid Model. [PDF]
PLoS ONE, 2015 Monitoring the DNA-Damage Response (DDR) activated pathway in multicellular tumor spheroid models is an important challenge as these 3D models have demonstrated their major relevance in pharmacological evaluation.
Odile Mondesert +5 more
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DNA damage response signaling: A common link between cancer and cardiovascular diseases
Cancer Medicine, 2023 DNA damage response (DDR) signaling ensures genomic and proteomic homeostasis to maintain a healthy genome. Dysregulation either in the form of down‐ or upregulation in the DDR pathways correlates with various pathophysiological states, including cancer ...
Sepideh Nikfarjam, Krishna K. Singh
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Frontiers in Oncology, 2021 BackgroundDNA damage repair (DDR) genes were recently implicated in the anti-tumor immune response. Therefore, it is worthwhile to unravel the implications of DDR pathways in the shaping of immune responsiveness in colorectal cancer (CRC) patients ...
Yipeng Song +12 more
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Frontiers in Oncology, 2021 DNA damage repair (DDR) pathways play an essential role in maintaining genomic integrity. DDR dysfunction leads to accumulated DNA damage, predisposition to cancer, and high sensitivity to chemotherapy and radiotherapy.
Wei Sun +5 more
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Journal for ImmunoTherapy of Cancer, 2020 Background Loss-of-function alterations in DNA damage repair (DDR) genes are associated with human tumorigenesis and may determine benefit from immune-oncology (I/O) agents as shown in colon cancer.
Andrea Knezevic +15 more
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Dynamic differences between DNA damage repair responses in primary tumors and cell lines
Translational Oncology, 2021 The study of DNA damage repair response (DDR) in prostate cancer is restricted by the limited number of prostate cancer cell lines and lack of surrogates for heterogeneity in clinical samples.
Collin Gilbreath +11 more
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Science-Business eXchange, 2011 An international team looking to target subsets of squamous cell lung cancer has identified mutations in DDR2 that drive 3%–4% of cases. The researchers are aiming to start a Phase II trial with Bristol-Myers's Sprycel, a marketed kinase inhibitor that blocks DDR2.
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