Results 31 to 40 of about 44,512 (277)
DDR-2 is required for efficient axon regeneration in C. elegans.
, 2016 (A) SVH-2–JNK MAPK pathway required for axon regeneration in C. elegans. The growth factor SVH-1 and its receptor tyrosine kinase SVH-2 promote axon regeneration through tyrosine phosphorylation of MLK-1 in the KGB-1 JNK pathway.
Strahil I. Pastuhov (3589694) +4 more
core +1 more source
EBioMedicine, 2019 Background: DNA damage repair (DDR) alterations are important events in cancer initiation, progression, and therapeutic resistance. However, the involvement of DDR alterations in glioma malignancy needs further investigation.
Xiangqi Meng +13 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2021 Genomic instability remains an enabling feature of cancer and promotes malignant transformation. Alterations of DNA damage response (DDR) pathways allow genomic instability, generate neoantigens, upregulate the expression of programmed death ligand 1 (PD-
Minlin Jiang +9 more
doaj +1 more source
Disarmament, demobilisation and reintegration (DDR) as a participatory process: involving communities and beneficiaries in post-conflict disarmament programmes [PDF]
, 2008 Disarmament, Demobilisation and Reintegration (DDR) programmes are a structured approach to returning soldiers and militia members to civilian life. One of the aims is to support implementation of the peace process, by addressing their interests and ...
Kilroy, Walt
core
DDR-2 modulates SVH-1–SVH-2 signaling to regulate axon regeneration after neuron injury.
, 2016 HGF/plasminogen-like protein SVH-1 is constitutively expressed in, and secreted from ADL sensory neurons in the head. Expression of SVH-2 is induced by axon injury.
Strahil I. Pastuhov (3589694) +4 more
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Disarmament, Demobilization, and Reintegration: The co-evolution of concepts, practices, and understanding [PDF]
, 2009 Programs for the Disarmament, Demobilization, and Reintegration (DDR) of ex-combatants have become more common as an element in the peacebuilder’s toolkit.
Kilroy, Walt
core
Sofortresonanzen DDR Fernsehen 3. Woche 1990 (SFR 3/90)
, 2011 Zuschauerbeteiligung und Fernsehverhalten. Themen: Sehbeteiligung und Bewertung der Sendungen in der Woche vor der Befragung; Zusatzfragen: Präferenz von Unterhaltungssendungen des BRD- oder DDR-Fernsehens; persönliche Erwartungen an das Fernsehprogramm;
Staatliches Komitee f\ufcr Fernsehen beim Ministerrat der DDR, Abteilung Soziologische Forschung, Berlin
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Diverse immune response of DNA damage repair-deficient tumors
Cell Reports Medicine, 2021 Summary: Tumors with DNA damage repair (DDR) deficiency accumulate genomic alterations that may serve as neoantigens and increase sensitivity to immune checkpoint inhibitor.
Tao Qing +6 more
doaj +1 more source