Results 31 to 40 of about 150,892 (276)
Targeting DNA damage response deficiency in the treatment of breast cancer [PDF]
Zhongguo aizheng zazhi, 2022 DNA damage response (DDR) deficiency has been one of the emerging targets in treating breast cancer in recent years. The DDR pathway is essential for the identification, signal transduction and repair of DNA damage.
JIN Yizi, LIN Mingxi, ZHANG Jian
doaj +1 more source
Targeting ATM pathway for therapeutic intervention in cancer [PDF]
, 2012 The Ataxia Telangiectasia Mutated gene encodes the ATM protein, a key element in the DNA damage response (DDR) signalling pathway responsible for maintaining genomic integrity within the cell.
Chakarov, Stoyan +4 more
core +3 more sources
The ubiquitin E3/E4 ligase, UBE4A, fine-tunes protein ubiquitylation and accumulation at sites of DNA damage facilitating double-strand break repair [PDF]
, 2018 Double-strand breaks (DSBs) are critical DNA lesions that robustly activate the elaborate DNA damage response (DDR) network. We identified a critical player in DDR fine-tuning - the E3/E4 ubiquitin ligase, UBE4A.
Baranes Bachar, Keren +4 more
core +1 more source
The DNA Damage Response Induced by Infection with Human Cytomegalovirus and Other Viruses
Viruses, 2014 Viruses use different strategies to overcome the host defense system. Recent studies have shown that viruses can induce DNA damage response (DDR).
Xiaofei E, Timothy F. Kowalik
doaj +1 more source
Transitional justice and peacebuilding on the ground [PDF]
, 2012 Policy brief drawing on the research conducted as part of a grant from the US Institute of Peace (USIP 002-09F) on victim-centred approaches to justice and DDR ...
Martin-Ortega, Olga
core +1 more source
Frontiers in Oncology, 2022 DNA damage repair (DDR) is essential for maintaining genome integrity and modulating cancer risk, progression, and therapeutic response. DDR defects are common among non-small lung cancer (NSCLC), resulting in new challenge and promise for NSCLC ...
Ling Li +9 more
doaj +1 more source
Frontiers in ImmunologyBackgroundImpaired DNA damage response (DDR) can affect immune checkpoint inhibitors (ICI) efficacy and lead to heightened immune activation. We assessed the impact of pathogenic or likely pathogenic (P/LP) germline DDR mutations on ICI response and ...
Michael J. Dennis +9 more
doaj +1 more source
Role of DNA repair defects in predicting immunotherapy response
Biomarker Research, 2020 Defect in DNA damage response (DDR) is a common feature of cancer cells, which regulates tumor growth and therapeutic response. Recently, the approval of immune checkpoint blockade (ICB) for tumors with defective mismatch repair has paved the way for ...
Jing Zhang +2 more
doaj +1 more source
SWI/SNF and Asf1 independently promote derepression of the DNA damage response genes under conditions of replication stress. [PDF]
PLoS ONE, 2011 The histone chaperone Asf1 and the chromatin remodeler SWI/SNF have been separately implicated in derepression of the DNA damage response (DDR) genes in yeast cells treated with genotoxins that cause replication interference.
Laura V Minard +2 more
doaj +1 more source
Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy
Frontiers in Immunology, 2021 The DNA damage response (DDR) is an organized network of multiple interwoven components evolved to repair damaged DNA and maintain genome fidelity.
Zu Ye +4 more
doaj +1 more source