Results 11 to 20 of about 150,892 (276)

Transcriptomic Profiling of DNA Damage Response in Patient-Derived Glioblastoma Cells before and after Radiation and Temozolomide Treatment

Cells, 2022
Glioblastoma is a highly aggressive, invasive and treatment-resistant tumour. The DNA damage response (DDR) provides tumour cells with enhanced ability to activate cell cycle arrest and repair treatment-induced DNA damage.
Mathew Lozinski, Nikola A. Bowden, Moira C. Graves, Michael Fay, Bryan W. Day, Brett W. Stringer, Paul A. Tooney   +6 more
doaj   +1 more source

Suppressor of gamma response 1 modulates the DNA damage response and oxidative stress response in leaves of cadmium-exposed Arabidopsis thaliana [PDF]

, 2020
Cadmium (Cd) exposure causes an oxidative challenge and inhibits cell cycle progression, ultimately impacting plant growth. Stress-induced effects on the cell cycle are often a consequence of activation of the DNA damage response (DDR).
Cuypers, Ann, De Veylder, Lieven, Eekhout, Thomas, Hendrix, Sophie, Horemans, Nele, Huybrechts, Michiel, Iven, Verena, Keunen, Els, Pecqueur, Ingeborg, Vangronsveld, Jaco   +9 more
core   +1 more source

COP9 signalosome function in the DDR [PDF]

FEBS Letters, 2011
The COP9 signalosome (CSN) is a platform for protein communication in eukaryotic cells. It has an intrinsic metalloprotease that removes the ubiquitin (Ub)‐like protein Nedd8 from cullins. CSN‐mediated deneddylation regulates culling‐RING Ub ligases (CRLs) and controls ubiquitination of proteins involved in DNA damage response (DDR).
Hannß, Ronny, Dubiel, Wolfgang
openaire   +2 more sources

DNA damage induced during mitosis undergoes DNA repair synthesis. [PDF]

, 2020
Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies.
Berns, Michael W, Cohen, Shirli, Gomez Godinez, Veronica, Kabbara, Sami, Kong, Xiangduo, Maravillas-Montero, Jose Luis, Preece, Daryl, Sherman, Adria, Shi, Zhixia, Wu, Tao, Yokomori, Kyoko   +10 more
core   +1 more source

Monitoring the Activation of the DNA Damage Response Pathway in a 3D Spheroid Model. [PDF]

PLoS ONE, 2015
Monitoring the DNA-Damage Response (DDR) activated pathway in multicellular tumor spheroid models is an important challenge as these 3D models have demonstrated their major relevance in pharmacological evaluation.
Odile Mondesert, Céline Frongia, Olivia Clayton, Marie-Laure Boizeau, Valérie Lobjois, Bernard Ducommun   +5 more
doaj   +1 more source

DNA Damage Repair Gene Mutations Are Indicative of a Favorable Prognosis in Colorectal Cancer Treated With Immune Checkpoint Inhibitors

Frontiers in Oncology, 2021
BackgroundDNA damage repair (DDR) genes were recently implicated in the anti-tumor immune response. Therefore, it is worthwhile to unravel the implications of DDR pathways in the shaping of immune responsiveness in colorectal cancer (CRC) patients ...
Yipeng Song, Jian Huang, Dandan Liang, Ying Hu, Beibei Mao, Qiujing Li, Huaibo Sun, Ying Yang, Jiao Zhang, Henghui Zhang, Huan Chen, Hao Liu, Shukun Zhang   +12 more
doaj   +1 more source

DNA damage response signaling: A common link between cancer and cardiovascular diseases

Cancer Medicine, 2023
DNA damage response (DDR) signaling ensures genomic and proteomic homeostasis to maintain a healthy genome. Dysregulation either in the form of down‐ or upregulation in the DDR pathways correlates with various pathophysiological states, including cancer ...
Sepideh Nikfarjam, Krishna K. Singh
doaj   +1 more source

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas [PDF]

, 2018
DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types.
Alvaro, Domenico, Andrew D, Cherniack, Bin, Feng, Bragazzi, MARIA CONSIGLIA, Cardinale, Vincenzo, Casey S, Greene, Chase, Miller, Chen, Wang, Christina, Yau, David A, Wheeler, Denise, Wolf, Eve, Shinbrot, Galen F, Gao, Gaudio, Eugenio, Gordon B, Mills, Gregory P, Way, Hai, Hu, Haoran, Chen, Hui, Shen, Huihui, Fan, Ilya, Shmulevich, Jianfang, Liu, John N, Weinstein, Lawrence A, Donehower, Lei, Li, Li, Ding, Linghua, Wang, Matthew H, Bailey, Michael T, Zimmermann, Mostafa, Karimi, Nyasha, Chambwe, Peilin, Jia, Peter W, Laird, Pora, Kim, Raymond J, Monnat, Rehan, Akbani, Shaojun, Zhang, Theo A, Knijnenburg, Yang, Shen, Yonghong, Xiao, Yuexin, Liu, Zhongming, Zhao   +41 more
core   +1 more source

Targeting DNA Damage Repair for Immune Checkpoint Inhibition: Mechanisms and Potential Clinical Applications

Frontiers in Oncology, 2021
DNA damage repair (DDR) pathways play an essential role in maintaining genomic integrity. DDR dysfunction leads to accumulated DNA damage, predisposition to cancer, and high sensitivity to chemotherapy and radiotherapy.
Wei Sun, Qing Zhang, Runkun Wang, Yang Li, Yue Sun, Lin Yang   +5 more
doaj   +1 more source

Germline and Somatic DNA Damage Repair Gene Mutations and Overall Survival in Metastatic Pancreatic Adenocarcinoma Patients Treated with FOLFIRINOX [PDF]

, 2018
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with lack of predictive biomarkers. We conducted a study to assess DNA damage repair (DDR) gene mutations as a predictive biomarker in PDAC patients treated with FOLFIRINOX ...
Gbolahan, Olumide, Hancock, Brad A., O'Neil, Bert H., Radovich, Milan, Sehdev, Amikar, Shahda, Safi, Stanley, Melissa, Wan, Jun, Wu, Howard H.   +8 more
core   +1 more source