Results 11 to 20 of about 44,512 (277)
Stable cellular senescence is associated with persistent DDR activation.
PLoS ONE, 2014 The DNA damage response (DDR) is activated upon DNA damage generation to promote DNA repair and inhibit cell cycle progression in the presence of a lesion.
Marzia Fumagalli +4 more
doaj +2 more sources
Frontiers in Oncology, 2021 BackgroundDNA damage repair (DDR) genes were recently implicated in the anti-tumor immune response. Therefore, it is worthwhile to unravel the implications of DDR pathways in the shaping of immune responsiveness in colorectal cancer (CRC) patients ...
Yipeng Song +12 more
doaj +1 more source
Monitoring the Activation of the DNA Damage Response Pathway in a 3D Spheroid Model. [PDF]
PLoS ONE, 2015 Monitoring the DNA-Damage Response (DDR) activated pathway in multicellular tumor spheroid models is an important challenge as these 3D models have demonstrated their major relevance in pharmacological evaluation.
Odile Mondesert +5 more
doaj +1 more source
DNA damage response signaling: A common link between cancer and cardiovascular diseases
Cancer Medicine, 2023 DNA damage response (DDR) signaling ensures genomic and proteomic homeostasis to maintain a healthy genome. Dysregulation either in the form of down‐ or upregulation in the DDR pathways correlates with various pathophysiological states, including cancer ...
Sepideh Nikfarjam, Krishna K. Singh
doaj +1 more source
Frontiers in Oncology, 2021 DNA damage repair (DDR) pathways play an essential role in maintaining genomic integrity. DDR dysfunction leads to accumulated DNA damage, predisposition to cancer, and high sensitivity to chemotherapy and radiotherapy.
Wei Sun +5 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2020 Background Loss-of-function alterations in DNA damage repair (DDR) genes are associated with human tumorigenesis and may determine benefit from immune-oncology (I/O) agents as shown in colon cancer.
Andrea Knezevic +15 more
doaj +1 more source
Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations
Life Science Alliance, 2022 Deleterious variants in the DNA damage repair system can cause genome instability and increase cancer risk. The highly ethnic-specific DDR deleterious variation from this study suggests its potential relationship with different disease susceptibility in ...
Zixin Qin +3 more
doaj +1 more source
Targeting DNA damage response deficiency in the treatment of breast cancer [PDF]
Zhongguo aizheng zazhi, 2022 DNA damage response (DDR) deficiency has been one of the emerging targets in treating breast cancer in recent years. The DDR pathway is essential for the identification, signal transduction and repair of DNA damage.
Yizi JIN, Mingxi LIN, Jian ZHANG
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Dynamic differences between DNA damage repair responses in primary tumors and cell lines
Translational Oncology, 2021 The study of DNA damage repair response (DDR) in prostate cancer is restricted by the limited number of prostate cancer cell lines and lack of surrogates for heterogeneity in clinical samples.
Collin Gilbreath +11 more
doaj +1 more source
The DNA Damage Response Induced by Infection with Human Cytomegalovirus and Other Viruses
Viruses, 2014 Viruses use different strategies to overcome the host defense system. Recent studies have shown that viruses can induce DNA damage response (DDR).
Xiaofei E, Timothy F. Kowalik
doaj +1 more source