Results 21 to 30 of about 44,512 (277)

A novel DNA damage repair-related gene signature predicting survival, immune infiltration and drug sensitivity in cervical cancer based on single cell sequencing

Frontiers in Immunology, 2023
BackgroundAberrant DNA damage repair (DDR) is one of the hallmarks of tumors, and therapeutic approaches targeting this feature are gaining increasing attention.
Xiaoqing Xiang, Jiawen Kang, Jingwen Jiang, Yaning Zhang, Yong Zhang, Lesai Li, Xiaoning Peng   +6 more
doaj   +1 more source

Alteration of DNA Damage Response Causes Cleft Palate

Frontiers in Physiology, 2021
Cleft palate is one of the most common craniofacial birth defects, however, little is known about how changes in the DNA damage response (DDR) cause cleft palate.
Hiroyuki Yamaguchi, Kohei Kitami, Xiao Wu, Li He, Jianbo Wang, Bin Wang, Bin Wang, Yoshihiro Komatsu, Yoshihiro Komatsu   +8 more
doaj   +1 more source

The DDR is in [PDF]

Science-Business eXchange, 2011
An international team looking to target subsets of squamous cell lung cancer has identified mutations in DDR2 that drive 3%–4% of cases. The researchers are aiming to start a Phase II trial with Bristol-Myers's Sprycel, a marketed kinase inhibitor that blocks DDR2.
openaire   +1 more source

Role of DNA repair defects in predicting immunotherapy response

Biomarker Research, 2020
Defect in DNA damage response (DDR) is a common feature of cancer cells, which regulates tumor growth and therapeutic response. Recently, the approval of immune checkpoint blockade (ICB) for tumors with defective mismatch repair has paved the way for ...
Jing Zhang, David J. H. Shih, Shiaw-Yih Lin   +2 more
doaj   +1 more source

A novel DNA damage repair-related signature for predicting prognositc and treatment response in non-small lung cancer

Frontiers in Oncology, 2022
DNA damage repair (DDR) is essential for maintaining genome integrity and modulating cancer risk, progression, and therapeutic response. DDR defects are common among non-small lung cancer (NSCLC), resulting in new challenge and promise for NSCLC ...
Ling Li, Bao-jia Zou, Juan-zhi Zhao, Jia-bi Liang, Zi-yue She, Wen-ying Zhou, Si-xiao Lin, Lin Tian, Wen-ji Luo, Fa-zhong He   +9 more
doaj   +1 more source

Germline DNA damage response gene mutations as predictive biomarkers of immune checkpoint inhibitor efficacy

Frontiers in Immunology
BackgroundImpaired DNA damage response (DDR) can affect immune checkpoint inhibitors (ICI) efficacy and lead to heightened immune activation. We assessed the impact of pathogenic or likely pathogenic (P/LP) germline DDR mutations on ICI response and ...
Michael J. Dennis, Michael J. Dennis, Sophia Bylsma, Lisa Madlensky, Lisa Madlensky, Meghana S. Pagadala, Hannah Carter, Hannah Carter, Sandip P. Patel, Sandip P. Patel   +9 more
doaj   +1 more source

SWI/SNF and Asf1 independently promote derepression of the DNA damage response genes under conditions of replication stress. [PDF]

PLoS ONE, 2011
The histone chaperone Asf1 and the chromatin remodeler SWI/SNF have been separately implicated in derepression of the DNA damage response (DDR) genes in yeast cells treated with genotoxins that cause replication interference.
Laura V Minard, Ling-ju Lin, Michael C Schultz   +2 more
doaj   +1 more source

Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy

Frontiers in Immunology, 2021
The DNA damage response (DDR) is an organized network of multiple interwoven components evolved to repair damaged DNA and maintain genome fidelity.
Zu Ye, Yin Shi, Yin Shi, Susan P. Lees-Miller, John A. Tainer   +4 more
doaj   +1 more source

Pathogenic variants in human DNA damage repair genes mostly arose after the latest human out-of-Africa migration

Frontiers in Genetics
IntroductionThe DNA damage repair (DDR) system in human genome is pivotal in maintaining genomic integrity. Pathogenic variation (PV) in DDR genes impairs their function, leading to genome instability and increased susceptibility to diseases, especially ...
Jun He, Si Hoi Kou, Jiaheng Li, Xiaofan Ding, San Ming Wang   +4 more
doaj   +1 more source

The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response. [PDF]

PLoS Pathogens, 2016
The DNA damage response (DDR) is a conglomerate of pathways designed to detect DNA damage and signal its presence to cell cycle checkpoints and to the repair machinery, allowing the cell to pause and mend the damage, or if the damage is too severe, to ...
Anna Brestovitsky, Keren Nebenzahl-Sharon, Peter Kechker, Rakefet Sharf, Tamar Kleinberger   +4 more
doaj   +1 more source