Results 21 to 30 of about 150,892 (276)
Journal for ImmunoTherapy of Cancer, 2020 Background Loss-of-function alterations in DNA damage repair (DDR) genes are associated with human tumorigenesis and may determine benefit from immune-oncology (I/O) agents as shown in colon cancer.
Andrea Knezevic +15 more
doaj +1 more source
Dynamic differences between DNA damage repair responses in primary tumors and cell lines
Translational Oncology, 2021 The study of DNA damage repair response (DDR) in prostate cancer is restricted by the limited number of prostate cancer cell lines and lack of surrogates for heterogeneity in clinical samples.
Collin Gilbreath +11 more
doaj +1 more source
A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages [PDF]
, 2017 Macrophages produce genotoxic agents, such as reactive oxygen and nitrogen species, that kill invading pathogens. Here we show that these agents activate the DNA damage response (DDR) kinases ATM and DNA-PKcs through the generation of double stranded ...
Akira +67 more
core +3 more sources
Genome-wide multi-parametric analysis of H2AX or γH2AX distributions during ionizing radiation-induced DNA damage response [PDF]
, 2013 Background: After induction of DNA double strand breaks (DSBs), the DNA damage response (DDR) is activated. One of the earliest events in DDR is the phosphorylation of serine 139 on the histone variant H2AX (gH2AX) catalyzed by phosphatidylinositol 3 ...
Cardoso, Maria Cristina +5 more
core +1 more source
Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox [PDF]
, 2020 To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have developed a set of complex signaling networks that detect these DNA lesions, orchestrate cell cycle checkpoints and ultimately lead to ...
Almeida, Sérgio F. de +3 more
core +4 more sources
Science-Business eXchange, 2011 An international team looking to target subsets of squamous cell lung cancer has identified mutations in DDR2 that drive 3%–4% of cases. The researchers are aiming to start a Phase II trial with Bristol-Myers's Sprycel, a marketed kinase inhibitor that blocks DDR2.
openaire +1 more source
How (not) to think of the ‘dead-donor’ rule [PDF]
, 2018 Although much has been written on the dead-donor rule in the last twenty-five years, scant attention has been paid to how it should be formulated, what its rationale is, and why it was accepted.
Omelianchuk, Adam
core +1 more source
Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations
Life Science Alliance, 2022 Deleterious variants in the DNA damage repair system can cause genome instability and increase cancer risk. The highly ethnic-specific DDR deleterious variation from this study suggests its potential relationship with different disease susceptibility in ...
Zixin Qin +3 more
doaj +1 more source
Frontiers in Immunology, 2023 BackgroundAberrant DNA damage repair (DDR) is one of the hallmarks of tumors, and therapeutic approaches targeting this feature are gaining increasing attention.
Xiaoqing Xiang +6 more
doaj +1 more source
Alteration of DNA Damage Response Causes Cleft Palate
Frontiers in Physiology, 2021 Cleft palate is one of the most common craniofacial birth defects, however, little is known about how changes in the DNA damage response (DDR) cause cleft palate.
Hiroyuki Yamaguchi +8 more
doaj +1 more source