Results 51 to 60 of about 44,512 (277)

Zur Geschichte der Psychotherapie in der DDR [PDF]

, 2011
The article presents the history of psychotherapy in the GDR giving special attention to the development of psychodynamic and psychoanalytic methods.
Maaz, Hans-Joachim, Hans-Joachim Maaz
core   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Sofortresonanzen DDR Fernsehen 19. Woche 1990 (SFR 19/90)

, 2011
Zuschauerbeteiligung und Fernsehverhalten. Themen: Sehbeteiligung und Bewertung der Sendungen in der Woche vor der Befragung; Zusatzfragen: Unterhaltungswert der Sendung KLOCK 8, ACHTERN STROM; Rezeptionshäufigkeit der Sendung TELE-LOTTO ...
Staatliches Komitee f\ufcr Fernsehen beim Ministerrat der DDR, Abteilung Soziologische Forschung, Berlin
core   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Sch9S6K controls DNA repair and DNA damage response efficiency in aging cells

Cell Reports
Summary: Survival from UV-induced DNA lesions relies on nucleotide excision repair (NER) and the Mec1ATR DNA damage response (DDR). We study DDR and NER in aging cells and find that old cells struggle to repair DNA and activate Mec1ATR.
Chiara Lucca, Elisa Ferrari, Ghadeer Shubassi, Arta Ajazi, Ramveer Choudhary, Christopher Bruhn, Vittoria Matafora, Angela Bachi, Marco Foiani   +8 more
doaj   +1 more source

DDR-Zeitschriften

PeriodIcon, 2023
To this day, GDR magazines have hardly been found worthy of a closer analytical look. As the present essay will argue, they have been treated primarily as containers for propaganda. In the introduction to this special issue on GDR magazines, the authors discuss why this has been the case so far and why GDR magazines in particular would be worth an ...
Vincent Fröhlich, Madleen Podewski
openaire   +1 more source

Sofortresonanzen DDR Fernsehen 16. Woche 1986 (SFR 16/86)

, 2011
Zuschauerbeteiligung und Fernsehverhalten. Themen: Sehbeteiligung und Bewertung der Sendungen in der Woche vor der Befragung; Zusatzfragen: Sendeplatz der Sendung ALLES SINGT - WEIL´S GUTE STIMMUNG bringt und Eignung für Altersgruppen sowie Bekanntheit ...
Staatliches Komitee f\ufcr Fernsehen beim Ministerrat der DDR, Abteilung Soziologische Forschung, Berlin
core   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Sofortresonanzen DDR Fernsehen 39. Woche 1990 (SFR 39/90)

, 2011
Zuschauerbeteiligung und Fernsehverhalten. Themen: Sehbeteiligung und Bewertung der Sendungen in der Woche vor der Befragung; Zusatzfragen: Bewertung des Auftretens des Gastgebers von GLÜCK MUSS MAN HABEN; bevorzugtes Spielpaar und Bewertung des ...
Staatliches Komitee f\ufcr Fernsehen beim Ministerrat der DDR, Abteilung Soziologische Forschung, Berlin
core   +1 more source

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang, Meidan Wei, Xiangrong Song, Jiaxin Zhang, Lisha Zhang, Sixian Chen, Yaoyu Hu, Hui Gao, Jianxiang Li   +8 more
wiley   +1 more source