Results 21 to 30 of about 30,219 (216)
Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations
Life Science Alliance, 2022 Deleterious variants in the DNA damage repair system can cause genome instability and increase cancer risk. The highly ethnic-specific DDR deleterious variation from this study suggests its potential relationship with different disease susceptibility in ...
Zixin Qin +3 more
doaj +1 more source
Alteration of DNA Damage Response Causes Cleft Palate
Frontiers in Physiology, 2021 Cleft palate is one of the most common craniofacial birth defects, however, little is known about how changes in the DNA damage response (DDR) cause cleft palate.
Hiroyuki Yamaguchi +8 more
doaj +1 more source
Targeting DNA damage response deficiency in the treatment of breast cancer [PDF]
Zhongguo aizheng zazhi, 2022 DNA damage response (DDR) deficiency has been one of the emerging targets in treating breast cancer in recent years. The DDR pathway is essential for the identification, signal transduction and repair of DNA damage.
JIN Yizi, LIN Mingxi, ZHANG Jian
doaj +1 more source
Frontiers in Immunology, 2023 BackgroundAberrant DNA damage repair (DDR) is one of the hallmarks of tumors, and therapeutic approaches targeting this feature are gaining increasing attention.
Xiaoqing Xiang +6 more
doaj +1 more source
Frontiers in Oncology, 2022 DNA damage repair (DDR) is essential for maintaining genome integrity and modulating cancer risk, progression, and therapeutic response. DDR defects are common among non-small lung cancer (NSCLC), resulting in new challenge and promise for NSCLC ...
Ling Li +9 more
doaj +1 more source
The DNA Damage Response Induced by Infection with Human Cytomegalovirus and Other Viruses
Viruses, 2014 Viruses use different strategies to overcome the host defense system. Recent studies have shown that viruses can induce DNA damage response (DDR).
Xiaofei E, Timothy F. Kowalik
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SWI/SNF and Asf1 independently promote derepression of the DNA damage response genes under conditions of replication stress. [PDF]
PLoS ONE, 2011 The histone chaperone Asf1 and the chromatin remodeler SWI/SNF have been separately implicated in derepression of the DNA damage response (DDR) genes in yeast cells treated with genotoxins that cause replication interference.
Laura V Minard +2 more
doaj +1 more source
Frontiers in ImmunologyBackgroundImpaired DNA damage response (DDR) can affect immune checkpoint inhibitors (ICI) efficacy and lead to heightened immune activation. We assessed the impact of pathogenic or likely pathogenic (P/LP) germline DDR mutations on ICI response and ...
Michael J. Dennis +9 more
doaj +1 more source
Role of DNA repair defects in predicting immunotherapy response
Biomarker Research, 2020 Defect in DNA damage response (DDR) is a common feature of cancer cells, which regulates tumor growth and therapeutic response. Recently, the approval of immune checkpoint blockade (ICB) for tumors with defective mismatch repair has paved the way for ...
Jing Zhang +2 more
doaj +1 more source
The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response. [PDF]
PLoS Pathogens, 2016 The DNA damage response (DDR) is a conglomerate of pathways designed to detect DNA damage and signal its presence to cell cycle checkpoints and to the repair machinery, allowing the cell to pause and mend the damage, or if the damage is too severe, to ...
Anna Brestovitsky +4 more
doaj +1 more source