Results 21 to 30 of about 149,069 (251)
Frontiers in Oncology, 2021 DNA damage repair (DDR) pathways play an essential role in maintaining genomic integrity. DDR dysfunction leads to accumulated DNA damage, predisposition to cancer, and high sensitivity to chemotherapy and radiotherapy.
Wei Sun +5 more
doaj +1 more source
Germline and Somatic DNA Damage Repair Gene Mutations and Overall Survival in Metastatic Pancreatic Adenocarcinoma Patients Treated with FOLFIRINOX [PDF]
, 2018 Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with lack of predictive biomarkers. We conducted a study to assess DNA damage repair (DDR) gene mutations as a predictive biomarker in PDAC patients treated with FOLFIRINOX ...
Gbolahan, Olumide +8 more
core +1 more source
Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox [PDF]
, 2020 To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have developed a set of complex signaling networks that detect these DNA lesions, orchestrate cell cycle checkpoints and ultimately lead to ...
Almeida, Sérgio F. de +3 more
core +4 more sources
Journal for ImmunoTherapy of Cancer, 2020 Background Loss-of-function alterations in DNA damage repair (DDR) genes are associated with human tumorigenesis and may determine benefit from immune-oncology (I/O) agents as shown in colon cancer.
Andrea Knezevic +15 more
doaj +1 more source
Dynamic differences between DNA damage repair responses in primary tumors and cell lines
Translational Oncology, 2021 The study of DNA damage repair response (DDR) in prostate cancer is restricted by the limited number of prostate cancer cell lines and lack of surrogates for heterogeneity in clinical samples.
Collin Gilbreath +11 more
doaj +1 more source
Autophagy in DNA Damage Response [PDF]
, 2015 DNA damage response (DDR) involves DNA repair, cell cycle regulation and apoptosis, but autophagy is also suggested to play a role in DDR. Autophagy can be activated in response to DNA-damaging agents, but the exact mechanism underlying this activation ...
Elzbieta Pawlowska +4 more
core +2 more sources
Science-Business eXchange, 2011 An international team looking to target subsets of squamous cell lung cancer has identified mutations in DDR2 that drive 3%–4% of cases. The researchers are aiming to start a Phase II trial with Bristol-Myers's Sprycel, a marketed kinase inhibitor that blocks DDR2.
openaire +1 more source
Alteration of DNA Damage Response Causes Cleft Palate
Frontiers in Physiology, 2021 Cleft palate is one of the most common craniofacial birth defects, however, little is known about how changes in the DNA damage response (DDR) cause cleft palate.
Hiroyuki Yamaguchi +8 more
doaj +1 more source
Targeting ATM pathway for therapeutic intervention in cancer [PDF]
, 2012 The Ataxia Telangiectasia Mutated gene encodes the ATM protein, a key element in the DNA damage response (DDR) signalling pathway responsible for maintaining genomic integrity within the cell.
Chakarov, Stoyan +4 more
core +3 more sources
The DNA Damage Response Induced by Infection with Human Cytomegalovirus and Other Viruses
Viruses, 2014 Viruses use different strategies to overcome the host defense system. Recent studies have shown that viruses can induce DNA damage response (DDR).
Xiaofei E, Timothy F. Kowalik
doaj +1 more source