Results 81 to 90 of about 30,219 (216)
The Multifaceted Role of Rad9 in the DNA Damage Response of Saccharomyces cerevisiae
Yeast, EarlyView.ABSTRACT To maintain the integrity of the genome, cells have evolved a complex signalling system, termed the DNA damage response (DDR), which detects DNA damage and promotes DNA repair. To date, over 600 proteins have been identified that play an integral role in the DDR. RAD9, encoding a DDR mediator protein, was the prototypical DNA damage checkpoint
A. Kiely +5 more
wiley +1 more source
Symposium Review: Wild Animal Welfare is in Our Backyards
The Bulletin of the Ecological Society of America, EarlyView.
Bonnie Fairbanks Flint +3 more
wiley +1 more source
Animal Conservation, EarlyView.The rapid expansion of wind energy across the Mediterranean region calls for more advanced tools to assess and mitigate its impacts on biodiversity. In this study, we present an innovative approach combining 13‐year satellite imagery analysis and ecological modelling, to assess the spatiotemporal overlap between wind energy development and habitat ...
Chiara Costantino +4 more
wiley +1 more source
Anticoagulant Rodenticides Contribute to a Decline in an Urban Carnivore
Animal Conservation, EarlyView.Anticoagulant rodenticides (ARs) have been shown to negatively affect carnivores globally and are closely tied to human activity and development. We examined drivers of annual survival in bobcats persisting on a residentially developed barrier island over 16 years.
Meghan P. Keating +7 more
wiley +1 more source
Asia-Pacific Journal of Clinical Oncology, EarlyView.Summary of the Asia Pacific Advanced Prostate Cancer Symposium 2025, showing disciplines and diversity of participants, discussion topics (high‐risk localized/locally advanced prostate cancer; PSA persistence and recurrence; radioligand therapy; genetics and genomics; bone protection and other aspects of supportive care), key themes, and high‐level ...
Edmund Chiong +28 more
wiley +1 more source
Alimentary Pharmacology &Therapeutics, EarlyView.Nationwide implementation of double reflex testing for hepatitis delta in Spain markedly increased anti‐HDV and HDV viral load testing between 2022 and 2024, enabling national seroprevalence estimates. Despite this progress, substantial regional heterogeneity persists, highlighting the need for standardised reflex diagnostic protocols.
Ana Alberola +95 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire +28 more
wiley +1 more source
Scientific ReportsInhibition of translation initiation using eIF4A inhibitors like (−)-didesmethylrocaglamide [(−)-DDR] and (−)-rocaglamide [(−)-Roc] is a potential cancer treatment strategy as they simultaneously diminish multiple oncogenic drivers.
Janet L. Oblinger +9 more
doaj +1 more source
Cancer Science, EarlyView.Using integrated spatial pathomics and transcriptomics, we show that neoadjuvant therapy (NAT) in pancreatic ductal adenocarcinoma (PDAC) induces substantial tumor microenvironment remodeling that is not captured by tumor regression grading (TRG) alone.
Xiaofei Zhang +16 more
wiley +1 more source
Seneca Valley virus infection exploits DNA damage response to facilitate viral replication
Journal of VirologySeneca Valley virus (SVV) is an emerging pathogen that causes severe vesicular diseases in swine, posing a significant threat to the global pork industry.
Jiangwei Song +7 more
doaj +1 more source