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The Warburg Effect 97 Years after Its Discovery [PDF]
Cancers, 2020 The deregulation of the oxidative metabolism in cancer, as shown by the increased aerobic glycolysis and impaired oxidative phosphorylation (Warburg effect), is coordinated by genetic changes leading to the activation of oncogenes and the loss of ...
Rosa M Pascale +2 more
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The Warburg Effect Revisited—Lesson from the Sertoli Cell
Medicinal Research Reviews, 2015 Otto Warburg observed that cancerous cells prefer fermentative instead of oxidative metabolism of glucose, although the former is in theory less efficient.
Pedro F Oliveira +2 more
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Current Opinion in Oncology, 2012
A revival of interest in tumor metabolism is underway and here we discuss recent results with a focus on the central theme of the Warburg effect, aerobic glycolysis.The M2 tumor-specific isoform of pyruvate kinase has generated much interest, but it has now been reported that PKM2 is not specific to tumors.
Bayley, J.P., Devilee, P.
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A revival of interest in tumor metabolism is underway and here we discuss recent results with a focus on the central theme of the Warburg effect, aerobic glycolysis.The M2 tumor-specific isoform of pyruvate kinase has generated much interest, but it has now been reported that PKM2 is not specific to tumors.
Bayley, J.P., Devilee, P.
openaire +3 more sources
Warburg Effect or Reverse Warburg Effect? A Review of Cancer Metabolism
Oncology Research and Treatment, 2015Cancer is a major threat to human health. A considerable amount of research has focused on elucidating the nature of cancer from its pathogenesis to treatment and prevention. Tumor cell metabolism has been considered a hallmark of cancer. Cancer cells differ from normal cells through unlimited cell division, and show a greater need for energy for their
Xiao Dong, Xu +8 more
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Targeting the Warburg Effect in Cancer: Where Do We Stand? [PDF]
International Journal of Molecular SciencesWarburg effect; Aerobic glycolysis; Tumor metabolismEfecto Warburg; Glucólisis aeróbica; Metabolismo tumoralEfecte Warburg; Glucòlisi aeròbica; Metabolisme tumoralThe Warburg effect, characterized by the preferential conversion of glucose to lactate even
Joan Seoane, Barba Ignasi
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Warburg effect in Gynecologic cancers
Journal of Obstetrics and Gynaecology Research, 2018AbstractMammalian cells produce energy by oxidative phosphorylation under aerobic conditions. However, in the 1920s, Otto Warburg reported the so‐called “Warburg effect” in which cancer cells produce ATP that is biased toward glycolysis rather than mitochondrial oxidative phosphorylation not only in anaerobic environment but also in aerobic environment.
Yusuke, Kobayashi +8 more
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The Warburg Effect and the Hallmarks of Cancer
Anti-Cancer Agents in Medicinal Chemistry, 2017It is a longstanding debate whether cancer is one disease or a set of very diverse diseases. The goal of this paper is to suggest strongly that most of (if not all) the hallmarks of cancer could be the consequence of the Warburg's effect. As a result of the metabolic impairment of the oxidative phosphorylation, there is a decrease in ATP concentration.
Schwartz, Laurent +2 more
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The Warburg effect: a signature of mitochondrial overload
Trends in Cell Biology, 2023A long-standing question in cancer biology has been why oxygenated tumors ferment the majority of glucose they consume to lactate rather than oxidizing it in their mitochondria, a phenomenon known as the 'Warburg effect.' An abundance of evidence shows not only that most cancer cells have fully functional mitochondria but also that mitochondrial ...
Yahui, Wang, Gary J, Patti
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Warburg and Krebs and related effects in cancer
Expert Reviews in Molecular Medicine, 2019AbstractWarburg and coworkers' observation of altered glucose metabolism in tumours has been neglected for several decades, which, in part, was because of an initial misinterpretation of the basis of their finding. Following the realisation that genetic alterations are often linked to metabolism, and that the tumour micro-environment imposes different ...
Judith E. Unterlass, Nicola J. Curtin
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Warburg effect and its role in tumourigenesis
Archives of Pharmacal Research, 2019Glucose is a crucial molecule in energy production and produces different end products in non-tumourigenic- and tumourigenic tissue metabolism. Tumourigenic cells oxidise glucose by fermentation and generate lactate and adenosine triphosphate even in the presence of oxygen (Warburg effect).
Maphuti T. Lebelo +2 more
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