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Cellular life span and the Warburg effect
Experimental Cell Research, 2008Enhanced glycolysis is observed in most of cancerous cells and tissues, called as the Warburg effect. Recent advance in senescent biology implicates that the metabolic shift to enhanced glycolysis would be involved in the early stage during multi-step tumorigenesis in vivo.
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Hypoxia, glucose metabolism and the Warburg’s effect
Journal of Bioenergetics and Biomembranes, 2007As described by Warburg more than 50 years ago, tumour cells maintain a high glycolytic rate even in conditions of adequate oxygen supply. However, most of tumours are subjected to hypoxic conditions due to the abnormal vasculature that supply them with oxygen and nutrients. Thus, glycolysis is essential for tumour survival and spread.
Ramon, Bartrons, Jaime, Caro
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Modulating Autophagy and the “Reverse Warburg Effect”
2014Autophagy is a highly regulated cellular pathway for degrading long-lived proteins and is the only known pathway for clearing cytoplasmic organelles. Autophagy is a major contributor to maintain cellular homeostasis and metabolism. The quality control of mitochondria is essential to maintain cell energy and this process appears to be achieved via ...
Vaccaro, Maria Ines +3 more
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The Warburg Effect and Aerobic Glycolysis in Tumors
A basic metabolic characteristic of carcinogenesis, namely the Warburg effect, is defined by the preferred utilization of aerobic glycolysis for energy generation in cancer cells, even in the presence of oxygen. Here, rapid proliferation and carefully planned adaptation to fulfill biosynthetic, redox, and survival requirements of malignant ...Bhupender, Nehra +6 more
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The Warburg Effect on Radioresistance: Survival Beyond Growth
Biochimica Et Biophysica Acta: Reviews on Cancer, 2023BuHyun Youn, Hyesook Youn, Hyunkoo Kang
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Historical Perspective of Tumor Glycolysis: A Century With Otto Warburg
Seminars in Cancer Biology, 2022Valeria Di Bussolo +2 more
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Revisiting the Warburg Effect: Historical Dogma Versus Current Understanding
Journal of Physiology, 2021Gabriele Multhoff, Peter Vaupel
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