Results 251 to 260 of about 133,879,868 (285)

Warburg Effect or Reverse Warburg Effect? A Review of Cancer Metabolism

Oncology Research and Treatment, 2015
Cancer is a major threat to human health. A considerable amount of research has focused on elucidating the nature of cancer from its pathogenesis to treatment and prevention. Tumor cell metabolism has been considered a hallmark of cancer. Cancer cells differ from normal cells through unlimited cell division, and show a greater need for energy for their
Xiao Dong, Xu, Shi Xiu, Shao, Hai Ping, Jiang, Yan Wei, Cao, Yong Hua, Wang, Xue Cheng, Yang, You Lin, Wang, Xin Sheng, Wang, Hai Tao, Niu   +8 more
openaire   +2 more sources

From Warburg Effect to Reverse Warburg Effect; The New Horizons of Anti-Cancer Therapy

Medical Hypotheses, 2020
An old ideology of killing the cancer cells by starving them is the underlying concept of the Warburg effect. It is the process of aerobic glycolysis exhibited by the cancer cells irrespective of anaerobic glycolysis or mitochondrial oxidative phosphorylation following by their healthy counterparts.
Sonu Benny
exaly   +3 more sources

The Warburg Effect and the Hallmarks of Cancer

Anti-Cancer Agents in Medicinal Chemistry, 2017
It is a longstanding debate whether cancer is one disease or a set of very diverse diseases. The goal of this paper is to suggest strongly that most of (if not all) the hallmarks of cancer could be the consequence of the Warburg's effect. As a result of the metabolic impairment of the oxidative phosphorylation, there is a decrease in ATP concentration.
Schwartz, Laurent, Supuran, Claudiu T, Alfarouk, Khalid O   +2 more
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Warburg effect in Gynecologic cancers

Journal of Obstetrics and Gynaecology Research, 2018
AbstractMammalian cells produce energy by oxidative phosphorylation under aerobic conditions. However, in the 1920s, Otto Warburg reported the so‐called “Warburg effect” in which cancer cells produce ATP that is biased toward glycolysis rather than mitochondrial oxidative phosphorylation not only in anaerobic environment but also in aerobic environment.
Yusuke, Kobayashi, Kouji, Banno, Haruko, Kunitomi, Takayuki, Takahashi, Takashi, Takeda, Kanako, Nakamura, Kosuke, Tsuji, Eiichiro, Tominaga, Daisuke, Aoki   +8 more
openaire   +2 more sources

Targeting the Warburg Effect in Cancer: Where Do We Stand? [PDF]

International Journal of Molecular Sciences
Warburg effect; Aerobic glycolysis; Tumor metabolismEfecto Warburg; Glucólisis aeróbica; Metabolismo tumoralEfecte Warburg; Glucòlisi aeròbica; Metabolisme tumoralThe Warburg effect, characterized by the preferential conversion of glucose to lactate even
Ignasi Barba, Joan Seoane
exaly   +2 more sources

Nuclear PKM2 Regulates the Warburg Effect [PDF]

Cell Cycle, 2013
Pyruvate kinase is a rate-limiting glycolytic enzyme. The PKM1 and PKM2 isoforms result from mutually exclusive alternative splicing of the PKM pre-mRNA. PKM2 rather than PKM1 regulates the Warburg effect and tumorigenesis by poorly understood mechanisms.
Weiwei Yang, Zhimin Lu
exaly   +3 more sources

Warburg and Krebs and related effects in cancer

Expert Reviews in Molecular Medicine, 2019
AbstractWarburg and coworkers' observation of altered glucose metabolism in tumours has been neglected for several decades, which, in part, was because of an initial misinterpretation of the basis of their finding. Following the realisation that genetic alterations are often linked to metabolism, and that the tumour micro-environment imposes different ...
Judith E. Unterlass, Nicola J. Curtin
openaire   +3 more sources

Warburg effect and its role in tumourigenesis

Archives of Pharmacal Research, 2019
Glucose is a crucial molecule in energy production and produces different end products in non-tumourigenic- and tumourigenic tissue metabolism. Tumourigenic cells oxidise glucose by fermentation and generate lactate and adenosine triphosphate even in the presence of oxygen (Warburg effect).
Maphuti T. Lebelo, Anna M. Joubert, Michelle H. Visagie   +2 more
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A century of the Warburg effect

Nature Metabolism, 2023
Craig B. Thompson, Karen H. Vousden, Randall S. Johnson, Willem H. Koppenol, Helmut Sies, Zhimin Lu, Lydia W. S. Finley, Christian Frezza, Jiyeon Kim, Zeping Hu, Caroline R. Bartman   +10 more
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Chronic lymphocytic leukemia and the Warburg effect

Blood, 2015
In this issue of Blood, Jitschin et al demonstrate a microenvironmental glycolytic shift in chronic lymphocytic leukemia (CLL) cells mediated by Notch-c-Myc signaling. Interfering in the Notch-c-Myc pathway and reprogramming glycolytic metabolism could contribute to overcoming drug resistance in CLL.
openaire   +2 more sources