Results 1 to 10 of about 5,021 (275)

High-Efficiency Biocatalytic Conversion of Thebaine to Codeine [PDF]

ACS Omega, 2020
An enzymatic biosynthesis approach is described for codeine, the most widely used medicinal opiate, providing a more environmentally sustainable alternative to current chemical conversion, with yields and productivity compatible with industrial production.
Xu Li, Konrad Krysiak-Baltyn, Luke Richards, Ailsa Jarrold, Geoffrey W. Stevens, Tim Bowser, Robert E. Speight, Sally L. Gras   +7 more
doaj   +7 more sources

Bioinformatics deciphers the thebaine biosynthesis pathway in opium poppy: Hub genes, network analysis, and miRNA regulation [PDF]

Journal of Genetic Engineering and Biotechnology
Thebaine, a vital precursor in the codeine and morphine pathway, shows promise in addiction treatment. We conducted a comprehensive study on the thebaine biosynthesis pathway in opium poppy, utilizing bioinformatics tools.
Zahra Shirazi, Mahsa Rostami, Abozar Ghorbani, Pietro Hiram Guzzi   +3 more
doaj   +3 more sources

Modification of Gene Expression Involved in Alkaloid Production in Opium Poppy by VIGS Combined With Pretreatment of Macerozyme Enzyme. [PDF]

Plant Direct
ABSTRACT Papaver somniferum L., a medicinal plant renowned for its pharmaceutical alkaloids, has captivated scientific interest due to its rich secondary metabolite profile. This study explores a novel approach to manipulating alkaloid biosynthesis pathways by integrating virus‐induced gene silencing (VIGS) with macerozyme enzyme pretreatment ...
Özcan DE, Köm D, Doğan O, Erişen S, Onarici S.   +4 more
europepmc   +2 more sources

Evaluation of Thermal Degradation of Tropane and Opium Alkaloids in Gluten-Free Corn Breadsticks Samples Contaminated with Stramonium Seeds and Baked with Poppy Seeds under Different Conditions [PDF]

Foods, 2022
In this work, the thermal degradation of tropane and opium alkaloids was studied in samples of breadsticks prepared with corn flour, contaminated with seeds of Datura stramonium, and containing seeds of Papaver somniferum L.
Fernando L. Vera-Baquero, Sonia Morante-Zarcero, Isabel Sierra   +2 more
doaj   +2 more sources

Codeine 3-O-demethylase catalyzed biotransformation of morphinan alkaloids in Escherichia coli: site directed mutagenesis of terminal residues improves enzyme expression, stability and biotransformation yield [PDF]

Journal of Biological Engineering
The cultivation of opium poppy is the only commercially viable source of most morphinan alkaloids. Bioproduction of morphinan alkaloids in recombinant whole-cell systems provides a promising alternate source of these valuable compounds.
Garrick W. K. Spencer, Xu Li, Kenny W. L. Lam, George Mutch, Fiona H. Fry, Sally L. Gras   +5 more
doaj   +2 more sources

THEBAINE METABOLITES IN THE URINE OF RHESUS MONKEYS

Japanese Journal of Pharmacology, 1981
The metabolic fate of thebaine in rhesus monkeys was investigated. Using thin layer chromatography, more than four metabolites were detected in the urine of monkeys given thebaine (8 mg/kg, s.c.). Two of the metabolites isolated by high performance liquid chromatography were not consistent with those reported previously.
Yasushi Yamazoe, Hiroaki Numata, Tomoji Yanagita   +2 more
  +6 more sources

Behavioral effects of thebaine in the rhesus monkey [PDF]

Pharmacology Biochemistry and Behavior, 1981
Three experiments were conducted with rhesus monkeys to assess some behavioral effects of the opium alkaloid, thebaine, in relation to its dependence liability. The concurrent intramuscular administration of naloxone did not antagonize the rate-decreasing effects of thebaine on a fixed-ratio (FR) schedule of food-reinforced responding.
James H. Woods, Charles R. Schuster, Christine R. Hartel   +2 more
openalex   +5 more sources

Development of chromatographic methods for thebaine detection and quantification along with some of related alkaloid derivatives

Macedonian Journal of Chemistry and Chemical Engineering, 2015
Thebaine is naturally occurring alkaloid  which is of great importance in the pharmaceutical industry and  up to now there is not a Pharmacopoeial monograph for this compound.
Marija Spasevska, Jane B Bogdanov, Hristina Babunovska   +2 more
doaj   +3 more sources

The effects of green and chemically-synthesized copper oxide nanoparticles on the production and gene expression of morphinan alkaloids in Oriental poppy [PDF]

Scientific Reports
Oriental poppy (Papaver orientale L.) belonging to the Papaveraceae family, has the capacity to synthesize a wide range of benzylisoquinoline alkaloids (BIAs).
Iman khaldari, Mohammad Reza Naghavi, Elaheh Motamedi, Meisam Zargar   +3 more
doaj   +2 more sources

Synthesis of sulfide-and disulfide-type bisaporphines from thebaine

ARKIVOC, 2004
Miklós Tóth, Csaba Csutorás, Zsuzsanna Gyulai, Sándor Berényi   +3 more
doaj   +3 more sources