Results 1 to 10 of about 3,256 (222)

Bioinformatics deciphers the thebaine biosynthesis pathway in opium poppy: Hub genes, network analysis, and miRNA regulation [PDF]

Journal of Genetic Engineering and Biotechnology
Thebaine, a vital precursor in the codeine and morphine pathway, shows promise in addiction treatment. We conducted a comprehensive study on the thebaine biosynthesis pathway in opium poppy, utilizing bioinformatics tools.
Zahra Shirazi, Mahsa Rostami, Abozar Ghorbani, Pietro Hiram Guzzi   +3 more
doaj   +2 more sources

Analysis of Illicit Street Heroin Seized in Pakistan by Gas Chromatography-Mass Spectrometry (GC-MS) for Identification of Adulterants and Impurities. [PDF]

Int J Anal Chem
Heroin abuse poses a significant public health and law enforcement challenge globally, with concerns in Pakistan due to the prevalence of illicit street heroin and limited data on its composition. This study analyzed 706 heroin samples seized between 2017 and 2022 using gas chromatography–mass spectrometry (GC‐MS) and Fourier transform infrared ...
Usman M, Baig Y, Naseer A, Nardiello D, Quinto M.   +4 more
europepmc   +2 more sources

Update on Opium Alkaloids in Food: Exploring Their Occurrence, Effect of Culinary Processing and Advances in Analytical Methodologies. [PDF]

Compr Rev Food Sci Food Saf
ABSTRACT Following the implementation of the new European legislation on opium alkaloids (OAs) in food in 2023, scientific research has focused on developing analytical methodologies to determine the presence of these compounds in different foods. However, health authorities continue to suggest further studies to evaluate the occurrence of main OAs and
Casado-Hidalgo G, Morante-Zarcero S, Sierra I.   +2 more
europepmc   +2 more sources

Traces of Use: Uncovering Drug Use Insights From Paraphernalia Analysis. [PDF]

Drug Alcohol Rev
ABSTRACT Introduction The residue analysis of disposed paraphernalia from people who inject drugs is a novel way to discern drug taking behaviours. This study aimed to investigate the presence of conventional and novel psychoactive substances (NPS) in drug paraphernalia in South Australia.
Keller EL, Peake B, Simpson BS, Longo M, White JM, Gerber C.   +5 more
europepmc   +2 more sources

Codeine 3-O-demethylase catalyzed biotransformation of morphinan alkaloids in Escherichia coli: site directed mutagenesis of terminal residues improves enzyme expression, stability and biotransformation yield [PDF]

Journal of Biological Engineering
The cultivation of opium poppy is the only commercially viable source of most morphinan alkaloids. Bioproduction of morphinan alkaloids in recombinant whole-cell systems provides a promising alternate source of these valuable compounds.
Garrick W. K. Spencer, Xu Li, Kenny W. L. Lam, George Mutch, Fiona H. Fry, Sally L. Gras   +5 more
doaj   +2 more sources

Modification of Gene Expression Involved in Alkaloid Production in Opium Poppy by VIGS Combined With Pretreatment of Macerozyme Enzyme. [PDF]

Plant Direct
ABSTRACT Papaver somniferum L., a medicinal plant renowned for its pharmaceutical alkaloids, has captivated scientific interest due to its rich secondary metabolite profile. This study explores a novel approach to manipulating alkaloid biosynthesis pathways by integrating virus‐induced gene silencing (VIGS) with macerozyme enzyme pretreatment ...
Özcan DE, Köm D, Doğan O, Erişen S, Onarici S.   +4 more
europepmc   +2 more sources

Oxycodone: A Pain-Relieving Agent With Cardioprotective Properties Against Myocardial Ischemia-Reperfusion Injury. [PDF]

Cardiovasc Ther
In the realm of cardiovascular diseases, myocardial ischemia–reperfusion injury (MIRI) is known as one of the main life‐threatening conditions with significant morbidity and mortality. Although some therapeutic approaches, like pharmacological treatments and ischemic preconditioning, have been suggested for MIRI, offering a functional approach with ...
Firoozabadi MD, Nooralishahi B, Rezaei-Tazangi F.   +2 more
europepmc   +2 more sources

The effects of green and chemically-synthesized copper oxide nanoparticles on the production and gene expression of morphinan alkaloids in Oriental poppy [PDF]

Scientific Reports
Oriental poppy (Papaver orientale L.) belonging to the Papaveraceae family, has the capacity to synthesize a wide range of benzylisoquinoline alkaloids (BIAs).
Iman khaldari, Mohammad Reza Naghavi, Elaheh Motamedi, Meisam Zargar   +3 more
doaj   +2 more sources

Chemiluminescence determination of pethidine hydrochloride and thebaine alkaloides [PDF]

شیمی کاربردی روز, 2023
The aim of this work was finding new flurescent dyes as sensitizers for chemiluminescence (CL) determination some of narcotics. In this way 6 different dyes incloding rhodamine 6G, brilliant blue, orange G, chromatrope, eosin‌‌Y and [Ru(phen)3]2+ and 14 ...
Massoud Karimi, Ali Mokhtari, Aliakbar Dehno Khalaji   +2 more
doaj   +1 more source

High-Efficiency Biocatalytic Conversion of Thebaine to Codeine

ACS Omega, 2020
Xu Li, Luke Richards, Ailsa Jarrold
exaly   +2 more sources