Salutaridine and its derivatives as thebaine-equivalents in the synthesis of aporphines [PDF]
Open Chemistry, 2013 Here we report on the transformation of tetracyclic morphinan salutaridine (1) into 2,3,10,11-tetrasubstituted (R)-aporphines. This method serves as another chemical proof of the previously verified biosynthetic connection with pentacyclic ...
Udvardy Antal, Sipos Attila
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High-Efficiency Biocatalytic Conversion of Thebaine to Codeine [PDF]
ACS Omega, 2020 Xu Li, Luke Richards, Ailsa Jarrold
exaly +3 more sources
Bioinformatics deciphers the thebaine biosynthesis pathway in opium poppy: Hub genes, network analysis, and miRNA regulation [PDF]
Journal of Genetic Engineering and BiotechnologyThebaine, a vital precursor in the codeine and morphine pathway, shows promise in addiction treatment. We conducted a comprehensive study on the thebaine biosynthesis pathway in opium poppy, utilizing bioinformatics tools.
Zahra Shirazi +3 more
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Macedonian Journal of Chemistry and Chemical Engineering, 2015 Thebaine is naturally occurring alkaloid which is of great importance in the pharmaceutical industry and up to now there is not a Pharmacopoeial monograph for this compound.
Marija Spasevska +2 more
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Investigation of the acid/base behaviour of the opium alkaloid thebaine in LC-ESI-MS mobile phase by NMR spectroscopy [PDF]
Royal Society Open Science, 2017 As part of a research programme to establish an analytical method for the simultaneous detection of the five major opium alkaloids in poppy seeds by liquid chromatography–electrospray ionization–mass spectrometry (LC-ESI-MS) it was discovered that the ...
Michelle G. Carlin +3 more
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Codeine 3-O-demethylase catalyzed biotransformation of morphinan alkaloids in Escherichia coli: site directed mutagenesis of terminal residues improves enzyme expression, stability and biotransformation yield [PDF]
Journal of Biological EngineeringThe cultivation of opium poppy is the only commercially viable source of most morphinan alkaloids. Bioproduction of morphinan alkaloids in recombinant whole-cell systems provides a promising alternate source of these valuable compounds.
Garrick W. K. Spencer +5 more
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Journal of Medicinal Plants, 2016 Background: Using of elicitors and different compounds in cell suspension culture is an effective strategy for enhancement and improvement of important secondary metabolites production in in vitro conditions.
R Farjaminezhad +3 more
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Evaluation of ultrasound effects on growth and biochemical characteristics of Iranian poppy cell cultures and thebaine production [PDF]
Zīst/shināsī-i Giyāhī-i Īrān, 2016 Low-energy ultrasound shows multiple physiological effects on plant cells and tissues, and has numerous applications in plant biotechnology, especially in elicitation of secondary metabolites production.
Ali Asghar Askari +4 more
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The effects of green and chemically-synthesized copper oxide nanoparticles on the production and gene expression of morphinan alkaloids in Oriental poppy [PDF]
Scientific ReportsOriental poppy (Papaver orientale L.) belonging to the Papaveraceae family, has the capacity to synthesize a wide range of benzylisoquinoline alkaloids (BIAs).
Iman khaldari +3 more
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