Results 21 to 30 of about 1,919 (204)
Thebaine is selectively demethylated by Thebaine 6-O-demethylase and Codeine-3-O-demethylase at distinct binding sites: A computational study [PDF]
, 2021 Two homologous 2-oxoglutarate-dependent (ODD) nonheme enzymes thebaine 6-O-demethylase (T6ODM) and codeine-3-O-demethylase (CODM), are involved in the morphine biosynthesis pathway from thebaine, catalyzing the O-demethylation reaction with precise ...
Li, Chun +7 more
core +1 more source
Modification of Gene Expression Involved in Alkaloid Production in Opium Poppy by VIGS Combined With Pretreatment of Macerozyme Enzyme. [PDF]
Plant DirectABSTRACT Papaver somniferum L., a medicinal plant renowned for its pharmaceutical alkaloids, has captivated scientific interest due to its rich secondary metabolite profile. This study explores a novel approach to manipulating alkaloid biosynthesis pathways by integrating virus‐induced gene silencing (VIGS) with macerozyme enzyme pretreatment ...
Özcan DE +4 more
europepmc +2 more sources
Macedonian Journal of Chemistry and Chemical Engineering, 2015 Thebaine is naturally occurring alkaloid which is of great importance in the pharmaceutical industry and up to now there is not a Pharmacopoeial monograph for this compound.
Marija Spasevska +2 more
doaj +1 more source
Foods, 2021 In recent years, health authorities have become increasingly concerned about preventing consumer exposure to opium alkaloids present in Papaver somniferum L. poppy seeds. In this study, a simple, rapid and efficient method has been optimised to determine
Gema Casado-Hidalgo +3 more
doaj +1 more source
Separation and identification of a number of alkaloids and some phenols from two species of plants of the genus Euphorbia grown in Nineveh Governorate. [PDF]
مجلة التربية والعلم, 2023 In this research, a number of chemical compounds were estimated and identified in the crude extract of both E. helioscopia and E. peplus species, as it was noted that there were about twenty alkaloid compounds in them, and It was, also, noted that there ...
Enas Qasim, Jehan Al-Hatem, Lubna abbas
doaj +1 more source
Studies on Cycloadducts of Thebaine and Thioaldehydes [PDF]
, 1993 A new route to the synthesis of 14beta-alkylmorphinans, of interest as potential analgesics, has been developed. Several such morphinans have been produced by desulphurisation of the Diels-Alder cycloadducts of thebaine and thioaldehydes, or of related ...
McQuillan, James Thomas
core +5 more sources
Pharmaceuticals, 2012 The in vitro shoot culture of a T-DNA insertional mutant of Papaver somniferum L. established by the infection of Agrobacterium rhizogenes MAFF03-01724 accumulated thebaine instead of morphine as a major opium alkaloid.
Kayo Yoshimatsu +3 more
doaj +1 more source
Model studies toward the total synthesis of thebaine by an intramolecular cycloaddition strategy [PDF]
, 2014 The present studies describe recent progress toward the synthesis of the thebaine. Model substrates were synthesized using pyridazine derivatives as a starting material, which allowed to assess the key Diels-Alder reaction as a route to construct the ...
Gupta, Setu
core +1 more source
Update of the Scientific Opinion on opium alkaloids in poppy seeds
EFSA Journal, 2018 Poppy seeds are obtained from the opium poppy (Papaver somniferum L.). They are used as food and to produce edible oil. The opium poppy plant contains narcotic alkaloids such as morphine and codeine.
EFSA Panel on Contaminants in the Food Chain (CONTAM) +32 more
doaj +1 more source
International Journal of Secondary Metabolite, 2017 The aim of this study is to determine the alkaloid and oil rates contents of some poppy (Papaver somniferum L.) varieties, such as morphine, codeine, oripavine, thebaine, noscapine and papaverine, which are planted as winter and summer. Five varieties of
Levent Yazıcı, Güngör Yılmaz
doaj +1 more source