Results 11 to 20 of about 1,809 (150)

Spray-Dried Engineered Escherichia coli Whole-Cell Biocatalysts Enable Cell Recycling and In Vivo α-Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture. [PDF]

Biotechnol Bioeng
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Jahanian A, Luna-Flores CH, Li X, Gras SL, Speight RE.   +4 more
europepmc   +2 more sources

Studies on Cycloadducts of Thebaine and Thioaldehydes [PDF]

, 1993
A new route to the synthesis of 14beta-alkylmorphinans, of interest as potential analgesics, has been developed. Several such morphinans have been produced by desulphurisation of the Diels-Alder cycloadducts of thebaine and thioaldehydes, or of related ...
McQuillan, James Thomas
core   +7 more sources

Extended-release buprenorphine in adults with opioid use disorder involving poppy seed tea: An 18-month retrospective case series. [PDF]

Am J Addict
Abstract Background and Objectives Poppy seed tea (PST) contains unpredictable opioid concentrations, destabilising tolerance and increasing overdose risk. Extended‐release buprenorphine (BUP‐XR) provides sustained coverage without daily dosing. Methods Eighteen‐month follow‐up of adults (N = 3) with opioid use disorder (OUD) involving PST in Australia.
McMaster J, Seshakumaran S, Abeysundera H, Tipirneni I, Hormiz R.   +4 more
europepmc   +2 more sources

Analysis of Illicit Street Heroin Seized in Pakistan by Gas Chromatography-Mass Spectrometry (GC-MS) for Identification of Adulterants and Impurities. [PDF]

Int J Anal Chem
Heroin abuse poses a significant public health and law enforcement challenge globally, with concerns in Pakistan due to the prevalence of illicit street heroin and limited data on its composition. This study analyzed 706 heroin samples seized between 2017 and 2022 using gas chromatography–mass spectrometry (GC‐MS) and Fourier transform infrared ...
Usman M, Baig Y, Naseer A, Nardiello D, Quinto M.   +4 more
europepmc   +2 more sources

Synthesis of Novel Morphinans From Thebaine [PDF]

, 1981
The synthesis of codeinone enol ethers from thebaine, via acetals of 14beta-bromocodeinone, has been successfully carried out. These enol ethers have, in turn, been converted into 6-alkoxy-6-desmethoxy-19-alkylthevinols, which have been shown to be ...
McDougall, Duncan Campbell
core   +6 more sources

Update on Opium Alkaloids in Food: Exploring Their Occurrence, Effect of Culinary Processing and Advances in Analytical Methodologies. [PDF]

Compr Rev Food Sci Food Saf
ABSTRACT Following the implementation of the new European legislation on opium alkaloids (OAs) in food in 2023, scientific research has focused on developing analytical methodologies to determine the presence of these compounds in different foods. However, health authorities continue to suggest further studies to evaluate the occurrence of main OAs and
Casado-Hidalgo G, Morante-Zarcero S, Sierra I.   +2 more
europepmc   +2 more sources

Traces of Use: Uncovering Drug Use Insights From Paraphernalia Analysis. [PDF]

Drug Alcohol Rev
ABSTRACT Introduction The residue analysis of disposed paraphernalia from people who inject drugs is a novel way to discern drug taking behaviours. This study aimed to investigate the presence of conventional and novel psychoactive substances (NPS) in drug paraphernalia in South Australia.
Keller EL, Peake B, Simpson BS, Longo M, White JM, Gerber C.   +5 more
europepmc   +2 more sources

The reactions of thebaine with C-nitroso-compounds

, 1972
The reactions of thebaine with nitrosoarenes to form Diels–Alder adducts have been investigated. Reversibility of the addition of a series of parasubstituted nitrosoarenes to thebaine has been qualitatively studied by NMR spectrometry.
Peter Horsewood (7166018)
core   +7 more sources

(-)-Thebaine [PDF]

, 1996
The structure of the opioid thebaine, 6,7,8,14-tetradehydro-4,5-epoxy-3,6-dimethoxy-17-methylmorphinan, C19H21NO3, has been determined by single-crystal X-ray diffraction techniques at low temperature.
Stevens, ED, C. H. Mahler, M. L. Trudell, S. P. Nolan, Trudell, ML, Mahler, CH, E. D. Stevens, Nolan, Steven   +7 more
core   +1 more source

Modification of Gene Expression Involved in Alkaloid Production in Opium Poppy by VIGS Combined With Pretreatment of Macerozyme Enzyme. [PDF]

Plant Direct
ABSTRACT Papaver somniferum L., a medicinal plant renowned for its pharmaceutical alkaloids, has captivated scientific interest due to its rich secondary metabolite profile. This study explores a novel approach to manipulating alkaloid biosynthesis pathways by integrating virus‐induced gene silencing (VIGS) with macerozyme enzyme pretreatment ...
Özcan DE, Köm D, Doğan O, Erişen S, Onarici S.   +4 more
europepmc   +2 more sources