Results 11 to 20 of about 1,919 (204)

(−)-Thebaine [PDF]

Acta Crystallographica Section C Crystal Structure Communications, 1996
The structure of the opioid thebaine, 6,7,8,14-tetradehydro-4,5-epoxy-3,6-dimethoxy-17-methylmorphinan, C19H21NO3, has been determined by single-crystal X-ray diffraction techniques at low temperature.
C. H. Mahler, E. D. Stevens, M. L. Trudell, S. P. Nolan   +3 more
openaire   +2 more sources

Behavioral effects of thebaine in the rhesus monkey [PDF]

Pharmacology Biochemistry and Behavior, 1981
Three experiments were conducted with rhesus monkeys to assess some behavioral effects of the opium alkaloid, thebaine, in relation to its dependence liability. The concurrent intramuscular administration of naloxone did not antagonize the rate-decreasing effects of thebaine on a fixed-ratio (FR) schedule of food-reinforced responding.
Woods, James H., Schuster, Charles R., Hartel, Christine R.   +2 more
openaire   +5 more sources

Spray-Dried Engineered Escherichia coli Whole-Cell Biocatalysts Enable Cell Recycling and In Vivo α-Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture. [PDF]

Biotechnol Bioeng
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Jahanian A, Luna-Flores CH, Li X, Gras SL, Speight RE.   +4 more
europepmc   +2 more sources

High variations of the thebaine concentrations in Iranian poppy (Papaver bracteatum Lindl.) from various regions in Iran [PDF]

Journal of Applied Botany and Food Quality
This paper aims to contribute reliable information to promote the pharmacological utilization of Papaver bracteatum by analyzing its wild population in Iran. For this purpose, 27 Iranian poppy specimens from 7 provinces of Iran were analyzed.
Mahdi Yahyazadeh, Mahshid Rahimifard, Najmeh Hadi, Zahra Shirazi, Samaneh Asadi-sanam, Razieh Azimi, Yousef Ajani, Maryam Makizadeh, Aiuob Moradi, Mahmood Bidarlord, Mozhgan Larti, Hamideh Fakhr-ranjbari, Negar Valizadeh, Taiebeh Amini, Dirk Selmar   +14 more
doaj   +2 more sources

Extended-release buprenorphine in adults with opioid use disorder involving poppy seed tea: An 18-month retrospective case series. [PDF]

Am J Addict
Abstract Background and Objectives Poppy seed tea (PST) contains unpredictable opioid concentrations, destabilising tolerance and increasing overdose risk. Extended‐release buprenorphine (BUP‐XR) provides sustained coverage without daily dosing. Methods Eighteen‐month follow‐up of adults (N = 3) with opioid use disorder (OUD) involving PST in Australia.
McMaster J, Seshakumaran S, Abeysundera H, Tipirneni I, Hormiz R.   +4 more
europepmc   +2 more sources

High-Efficiency Biocatalytic Conversion of Thebaine to Codeine [PDF]

ACS Omega, 2020
An enzymatic biosynthesis approach is described for codeine, the most widely used medicinal opiate, providing a more environmentally sustainable alternative to current chemical conversion, with yields and productivity compatible with industrial ...
Xu Li, Konrad Krysiak-Baltyn, Luke Richards, Ailsa Jarrold, Geoffrey W. Stevens, Tim Bowser, Robert E. Speight, Sally L. Gras   +7 more
doaj   +3 more sources

Analysis of Illicit Street Heroin Seized in Pakistan by Gas Chromatography-Mass Spectrometry (GC-MS) for Identification of Adulterants and Impurities. [PDF]

Int J Anal Chem
Heroin abuse poses a significant public health and law enforcement challenge globally, with concerns in Pakistan due to the prevalence of illicit street heroin and limited data on its composition. This study analyzed 706 heroin samples seized between 2017 and 2022 using gas chromatography–mass spectrometry (GC‐MS) and Fourier transform infrared ...
Usman M, Baig Y, Naseer A, Nardiello D, Quinto M.   +4 more
europepmc   +2 more sources

Update on Opium Alkaloids in Food: Exploring Their Occurrence, Effect of Culinary Processing and Advances in Analytical Methodologies. [PDF]

Compr Rev Food Sci Food Saf
ABSTRACT Following the implementation of the new European legislation on opium alkaloids (OAs) in food in 2023, scientific research has focused on developing analytical methodologies to determine the presence of these compounds in different foods. However, health authorities continue to suggest further studies to evaluate the occurrence of main OAs and
Casado-Hidalgo G, Morante-Zarcero S, Sierra I.   +2 more
europepmc   +2 more sources

Synthesis of Novel Morphinans From Thebaine [PDF]

, 1981
The synthesis of codeinone enol ethers from thebaine, via acetals of 14beta-bromocodeinone, has been successfully carried out. These enol ethers have, in turn, been converted into 6-alkoxy-6-desmethoxy-19-alkylthevinols, which have been shown to be ...
McDougall, Duncan Campbell
core   +4 more sources

Traces of Use: Uncovering Drug Use Insights From Paraphernalia Analysis. [PDF]

Drug Alcohol Rev
ABSTRACT Introduction The residue analysis of disposed paraphernalia from people who inject drugs is a novel way to discern drug taking behaviours. This study aimed to investigate the presence of conventional and novel psychoactive substances (NPS) in drug paraphernalia in South Australia.
Keller EL, Peake B, Simpson BS, Longo M, White JM, Gerber C.   +5 more
europepmc   +2 more sources