Results 11 to 20 of about 5,021 (275)

Salutaridine and its derivatives as thebaine-equivalents in the synthesis of aporphines [PDF]

Open Chemistry, 2013
Here we report on the transformation of tetracyclic morphinan salutaridine (1) into 2,3,10,11-tetrasubstituted (R)-aporphines. This method serves as another chemical proof of the previously verified biosynthetic connection with pentacyclic ...
Udvardy Antal, Sipos Attila
doaj   +4 more sources

Investigation of the acid/base behaviour of the opium alkaloid thebaine in LC-ESI-MS mobile phase by NMR spectroscopy [PDF]

Royal Society Open Science, 2017
As part of a research programme to establish an analytical method for the simultaneous detection of the five major opium alkaloids in poppy seeds by liquid chromatography–electrospray ionization–mass spectrometry (LC-ESI-MS) it was discovered that the ...
Michelle G. Carlin, John R. Dean, Jonathan L. Bookham, Justin J. B. Perry   +3 more
doaj   +2 more sources

Update of the Scientific Opinion on opium alkaloids in poppy seeds [PDF]

EFSA Journal, 2018
Poppy seeds are obtained from the opium poppy (Papaver somniferum L.). They are used as food and to produce edible oil. The opium poppy plant contains narcotic alkaloids such as morphine and codeine.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Jan Alexander, Lars Barregård, Margherita Bignami, Beat Brüschweiler, Sandra Ceccatelli, Bruce Cottrill, Michael Dinovi, Lutz Edler, Bettina Grasl‐Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Carlo Stefano Nebbia, Isabelle P Oswald, Annette Petersen, Martin Rose, Alain‐Claude Roudot, Tanja Schwerdtle, Günter Vollmer, Heather Wallace, Diane Benford, Girolamo Calò, Albert Dahan, Birgit Dusemund, Patrick Mulder, Éva Németh‐Zámboriné, Davide Arcella, Katleen Baert, Claudia Cascio, Sara Levorato, Marijke Schutte, Christiane Vleminckx   +32 more
doaj   +2 more sources

Determination of morphine, codeine, thebaine, papaverine and noscapine in rat plasma by UPLC-MS/MS [PDF]

Acta Chromatographica, 2023
In this work, a UPLC-MS/MS assay was established for the determination of morphine, codeine, thebaine, papaverine and noscapine in rat plasma. ACQUITY UPLC BEH C18 column was employed for chromatographic separation with the mobile phase comprised ...
Ying Wang, Yifan He, Xianqin Wang, Congcong Wen, Jianbin Cao   +4 more
openalex   +2 more sources

High variations of the thebaine concentrations in Iranian poppy (Papaver bracteatum Lindl.) from various regions in Iran [PDF]

Journal of Applied Botany and Food Quality
This paper aims to contribute reliable information to promote the pharmacological utilization of Papaver bracteatum by analyzing its wild population in Iran. For this purpose, 27 Iranian poppy specimens from 7 provinces of Iran were analyzed.
Mahdi Yahyazadeh, Mahshid Rahimifard, Najmeh Hadi, Zahra Shirazi, Samaneh Asadi-sanam, Razieh Azimi, Yousef Ajani, Maryam Makizadeh, Aiuob Moradi, Mahmood Bidarlord, Mozhgan Larti, Hamideh Fakhr-ranjbari, Negar Valizadeh, Taiebeh Amini, Dirk Selmar   +14 more
doaj   +4 more sources

Semi-synthesis of novel thebaine derivatives with low cytotoxicity and their antibacterial and antihemolytic properties [PDF]

Medicinal Chemistry Research, 2023
In the present study, some new 1,2,3-triazole-tethered analogs of N -northebaine were designed and synthesized. The anti-bacterial properties of novel thebaine derivatives were studied on Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli
Zahra Hasanpour, Peyman Salehi, Atousa Aliahmadi, Mahdieh Hoseinpour, Hossein Behboodi, Dan Stærk, Morteza Bararjanian   +6 more
semanticscholar   +3 more sources

Thebaine is Selectively Demethylated by Thebaine 6-O-Demethylase and Codeine-3-O-demethylase at Distinct Binding Sites: A Computational Study [PDF]

Inorganic Chemistry, 2021
Two homologous 2-oxoglutarate-dependent (ODD) nonheme enzymes thebaine 6-O-demethylase (T6ODM) and codeine-3-O-demethylase (CODM), are involved in the morphine biosynthesis pathway from thebaine, catalyzing the O-demethylation reaction with precise ...
Warispreet Singh, Chenggong Hui, Chun Li, Meilan Huang   +3 more
openalex   +2 more sources

Optimization of Thebaine Production using Adventitious Roots of Papaver bracteatum Lindle. by Alteration of Aeration Volume and Temperature in Bioreactor

Journal of Medicinal Plants, 2019
Background: Nowadays, the optimization of the culture conditions in bioreactors is considered as an approach to produce secondary metabolites such as thebaine.
N Qavami, H Naghdi Badi, A Qaderi, A Mehrafarin, F Khalighi-Sigaroodi, AR Zare Karizi   +5 more
doaj   +2 more sources

Concentrations of the Opium Alkaloids Morphine, Codeine, and Thebaine in Poppy Seeds are Reduced after Thermal and Washing Treatments but are Not Affected when Incorporated in a Model Baked Product

Journal of Agricultural and Food Chemistry, 2020
Limited information exists on the effectiveness of potential treatments to reduce levels of opium alkaloids that may be present in seeds from poppy (Papaver somniferum L.).
Shalaka A. Shetge, Michael P. Dzakovich, Jessica L. Cooperstone, Daria Kleinmeier, Benjamin W. Redan   +4 more
openalex   +3 more sources

B-323 Urinary Thebaine Improves Opioid Interpretation in Pain Management [PDF]

Clinical Chemistry, 2023
Poppy seed from Papaver somniferum plant is used in bakery results in positive urine test for Morphine and Codeine up to 48 h. This leads to prescription compliance failure in the setting of clinical pain management.
Niloufar Pourfarrokh, Nam Q. Nguyen
openalex   +2 more sources