Results 51 to 60 of about 5,407 (177)

Design, Synthesis and Assay of Novel Methylxanthine–Alkynylmethylamine Derivatives as Acetylcholinesterase Inhibitors

Molecules, 2022
Xanthine derivatives have been a great area of interest for the development of potent bioactive agents. Thirty-eight methylxanthine derivatives as acetylcholinesterase inhibitors (AChE) were designed and synthesized.
Danila V. Reshetnikov, Igor D. Ivanov, Dmitry S. Baev, Tatyana V. Rybalova, Evgenii S. Mozhaitsev, Sergey S. Patrushev, Valentin A. Vavilin, Tatyana G. Tolstikova, Elvira E. Shults   +8 more
doaj   +1 more source

Effect of molecular perturbation on cocrystal formation: theophylline and its 8‐halo analogues with flavonoids

Acta Crystallographica Section C, Volume 82, Issue 8, Page 414-426, August 2026.
The tendency for alkaloid–flavonoid cocrystal formation is found to be markedly different for theophylline (Tph) compared to its 8‐halo analogues. Through screening with 13 common flavonoids, Tph is found to form cocrystals with six flavonoids, whereas 8‐Cl‐Tph and 8‐Br‐Tph each form cocrystals with just two, myricetin and kaempferol.
Weijian Ye, Herman H-Y. Sung, Ian D. Williams   +2 more
wiley   +1 more source

Transcriptional Regulation of the Novel Theacrine Synthase Gene CsTcS2 by the CsTINY–CsWRKY33 Module Underpins Theacrine Biosynthesis in Camellia sinensis

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4823-4843, August 2026.
ABSTRACT Theacrine (1,3,7,9‐tetramethyluric acid) is a purine alkaloid detected in multiple wild and specialised tea germplasms (Camellia sinensis) from South China, including Kucha. However, the molecular mechanisms governing its biosynthesis remain poorly understood. Here, we identify CsTcS2 as a novel theacrine synthase in tea plant.
Ting Wu, Lihua Zhu, Chenyu Shao, Siyi Xie, Na Li, Xinyu Li, Fang Wang, Lvwen Peng, Huiying Jin, Fanghuizi Shang, Jianan Huang, Zhonghua Liu, Na Tian, Shuoqian Liu   +13 more
wiley   +1 more source

Genetic variation of phytochemical compounds in progenies of Ilex paraguariensis St. Hil. [PDF]

Crop Breeding and Applied Biotechnology, 2009
Mate (Ilex paraguariensis St. Hil) contains phytochemical compounds capable of preventing a number of healthproblems. Knowledge on the genetic contribution to the variability in these compounds can help to obtain mate progenies withhigher levels thereof ...
Euclides Lara Cardozo Junior, Carmem Maria Donaduzzi, Ivan Schuster, Keiko Leonice Nakamura   +3 more
doaj  

Long‐term adverse cardiovascular changes induced by cocoa shell extract administration through lactation in fetal undernourished and control rats

Experimental Physiology, Volume 111, Issue 8, Page 3667-3683, 1 August 2026.
Abstract Cocoa shell extract (CSE; rich in antioxidant compounds) administered to adult hypertensive rats exposed to fetal undernutrition (MUN) reduces blood pressure, improving cardiovascular alterations. We aimed to explore lactation as a reprogramming window, evaluating the long‐term effects of CSE supplementation during this period. MUN and control
Santiago Ruvira, Pilar Rodríguez‐Rodríguez, Metee Iampanichakul, Begoña Quintana‐Villamandos, Dolores Morales, David Ramiro‐Cortijo, Silvia M. Arribas   +6 more
wiley   +1 more source

Synthesis and physical-chemical properties of 8-benzylidenhydrazino-1-(4-fluorobenzyl)theobromine derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2014
The aim of the work is thesynthesis and research of physical and chemical properties of earlier undescribed 1,8-disubstituted of theobromine, which are potential biologically active compounds.
D. G. Ivanchenko, M. I. Romanenko, E. V. Alexandrova, A. S. Korjova   +3 more
doaj   +1 more source

The Effect of CYP1A2 Gene Polymorphisms on Caffeine Pharmacokinetics and Exercise Performance in Male Recreational Athletes

European Journal of Sport Science, Volume 26, Issue 7, July 2026.
ABSTRACT This study examined the effects of caffeine consumption on endurance exercise performance, and the influence of CYP1A2 gene polymorphisms in caffeine pharmacokinetics and exercise performance. The data sets of two randomised, double blind, placebo‐controlled crossover study design experiments have been merged.
Chloe Masters, Ajmol Ali, Claire Badenhorst, Martin Dickens, Kay Rutherfurd‐Markwick   +4 more
wiley   +1 more source

Analysis of operating variables for Yerba mate leaves supercritical carbon dioxide extraction [PDF]

Chemical Industry and Chemical Engineering Quarterly, 2018
Given the increasing demand for potassium in Brazil, the mining and use of carnallite is becoming increasingly important, because the current source of potassium, sylvinite, is being depleted and there is a risk of shortages.
Teofilović Branislava, Grujić-Letić Nevena, Kovačević Strahinja, Podunavac-Kuzmanović Sanja, Gadžurić Slobodan   +4 more
doaj   +1 more source

Toxicity of aqueous extracts of Ilex paraguariensis A.St.‐Hil. about Euphorbia heterophylla L.

Pest Management Science, Volume 82, Issue 7, Page 6196-6206, July 2026.
Aqueous extracts of Ilex paraguariensis A.St.‐Hil. strongly inhibit Euphorbia heterophylla L. germination and early seedling growth, but show mild phytotoxicity on mature plants, paradoxically promoting biomass via antioxidants. Abstract BACKGROUND The escalating challenge of herbicide‐resistant weeds, exemplified by Euphorbia heterophylla L.
Tamara Alberton da Silva, Ikram Bashir, Ana Caroline Giacomin, Jéssica Adriane Barth, Marina Chiapperin, Fabieli Zanotelli de Oliveira, Camila Thaís Scheibler, Fernanda Bruxel, Elisete Maria de Freitas   +8 more
wiley   +1 more source

Integrated transcriptome–metabolome analyses reveal regulatory networks underlying soluble solids accumulation in Capsicum chinense fruits

The Plant Journal, Volume 127, Issue 1, July 2026.
SUMMARY The Capsicum genus shows remarkable phenotypic diversity, making it an excellent system to study non‐climacteric fruit ripening. Unlike climacteric model species, such as tomato (Solanum lycopersicum), the regulatory networks linking transcriptome and metabolome to fruit quality traits remain poorly understood in non‐climacteric crop species ...
Wesley Elias Bhering Barrios, Acácio Rodrigues‐Salvador, Rebeca Patrícia Omena‐Garcia, Débora Gonçalves Gouveia, Caris dos Santos Viana, Laise Rosado‐Souza, Pedro Marcus Pereira Vidigal, Diego Mauricio Riaño‐Pachón, Federico Scossa, Alisdair R. Fernie, Wagner L. Araújo, Agustin Zsögön, Adriano Nunes‐Nesi   +12 more
wiley   +1 more source