Results 11 to 20 of about 85,969 (275)

Signaling Pathways Regulating Thermogenesis [PDF]

Frontiers in Endocrinology, 2021
Obesity, an excess accumulation of white adipose tissue (WAT), has become a global epidemic and is associated with complex diseases, such as type 2 diabetes and cardiovascular diseases. Presently, there are no safe and effective therapeutic agents to treat obesity.
Chihiro Nakamura-Tabuchi, Hei Sook Sul
semanticscholar   +7 more sources

Diet induced thermogenesis [PDF]

Nutrition & Metabolism, 2004
Objective Daily energy expenditure consists of three components: basal metabolic rate, diet-induced thermogenesis and the energy cost of physical activity. Here, data on diet-induced thermogenesis are reviewed in relation to measuring conditions and
Westerterp KR
doaj   +4 more sources

Cold exposure induces lipid dynamics and thermogenesis in brown adipose tissue of goats

BMC Genomics, 2022
Background Adaptive thermogenesis by brown adipose tissue (BAT) is important to the maintenance of temperature in newborn mammals. Cold exposure activates gene expression and lipid metabolism to provide energy for BAT thermogenesis. However, knowledge of
Xin Liu, Jing Tang, Runan Zhang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Jiaxue Cao, Li Li, Hongping Zhang, Linjie Wang   +10 more
doaj   +2 more sources

Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis [PDF]

Nature Metabolism, 2023
Grace Park, John D. Haley, Johnny Le, Su Myung Jung, Timothy P. Fitzgibbons, Ekaterina Korobkina, Huawei Li, Shelagh M. Fluharty, Qingbo Chen, Jessica B. Spinelli, Chinmay M. Trivedi, Cholsoon Jang, David A. Guertin   +12 more
openalex   +2 more sources

Hypothalamic control of energy expenditure and thermogenesis

Experimental and Molecular Medicine, 2022
Energy expenditure and energy intake need to be balanced to maintain proper energy homeostasis. Energy homeostasis is tightly regulated by the central nervous system, and the hypothalamus is the primary center for the regulation of energy balance.
L. Tran, Sohee Park, Seul Ki Kim, Jin Sun Lee, Ki Woo Kim, Obin Kwon   +5 more
semanticscholar   +1 more source

Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis

Science Advances, 2023
Thermogenesis by uncoupling protein 1 (UCP1) is one of the primary mechanisms by which brown adipose tissue (BAT) increases energy expenditure. UCP1 resides in the inner mitochondrial membrane (IMM), where it dissipates membrane potential independent of ...
Jordan M. Johnson, Alek D. Peterlin, E. Balderas, E. Sustarsic, J. Maschek, Marisa J. Lang, Alejandro Jara-Ramos, Vanja Panic, J. Morgan, Claudio J. Villanueva, Alejandro Sanchez, J. Rutter, I. Lodhi, J. Cox, Kelsey H. Fisher-Wellman, D. Chaudhuri, Zachary Gerhart-Hines, K. Funai   +17 more
semanticscholar   +1 more source

The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice

Nature Communications, 2023
Skeletal muscle and thermogenic adipose tissue are both critical for the maintenance of body temperature in mammals. However, whether these two tissues are interconnected to modulate thermogenesis and metabolic homeostasis in response to thermal stress ...
Lu Jin, Shuang Han, Xue Lv, Xiaofei Li, Ziyin Zhang, Henry Kuang, Zhimin Chen, Cheng-An Lv, Wei Peng, Zhuoying Yang, Miqi Yang, Lin Mi, Tongyu Liu, Shengshan Ma, Xinyuan Qiu, Qintao Wang, Xiaowen Pan, Pengfei Shan, Yu Feng, Jin Li, Fudi Wang, Liwei Xie, Xu-Yun Zhao, Jun-Fen Fu, Jiandie D. Lin, Z. Meng   +25 more
semanticscholar   +1 more source

Time-restricted feeding mitigates obesity through adipocyte thermogenesis

Science, 2022
Misalignment of feeding rhythms with the light-dark cycle leads to disrupted peripheral circadian clocks and obesity. Conversely, restricting feeding to the active period mitigates metabolic syndrome through mechanisms that remain unknown.
Chelsea Hepler, Benjamin J Weidemann, Nathan J Waldeck, B. Marcheva, J. Cedernaes, Anneke K. Thorne, Yumiko Kobayashi, Rino Nozawa, M. Newman, Peng Gao, Mengle Shao, K. M. Ramsey, Rana K. Gupta, J. Bass   +13 more
semanticscholar   +1 more source

β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis

JCI Insight, 2021
β3-Adrenergic receptors (β3-ARs) are the predominant regulators of rodent brown adipose tissue (BAT) thermogenesis. However, in humans, the physiological relevance of BAT and β3-AR remains controversial.
C. Cero, H. Lea, K. Zhu, F. Shamsi, Y. Tseng, A. Cypess   +5 more
semanticscholar   +1 more source

Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair thermogenesis and protect against diet-induced insulin resistance

Journal of Clinical Investigation, 2022
Brown adipose tissue (BAT), a crucial heat-generating organ, regulates whole-body energy metabolism by mediating thermogenesis. BAT inflammation is implicated in the pathogenesis of mitochondrial dysfunction and impaired thermogenesis.
Yanrui Huang, J. H. Zhou, Haifeng Zhang, A. Canfrán‐Duque, Abhishek K. Singh, R. Perry, G. Shulman, C. Fernández-Hernando, W. Min   +8 more
semanticscholar   +1 more source