Results 41 to 50 of about 33,124 (202)

MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme

Nature Communications, 2020
Mitochondria maintain a balance between thermogenesis and ATP synthesis, but how this is coordinated is largely unknown. Here, the authors show that MFSD7C coordinates ATP synthesis and thermogenesis in response to heme by directly binding to electron ...
Yingzhong Li, Nikola A. Ivica, Ting Dong, Dimitrios P. Papageorgiou, Yanpu He, Douglas R. Brown, Marianna Kleyman, Guangan Hu, Walter W. Chen, Lucas B. Sullivan, Amanda Del Rosario, Paula T. Hammond, Matthew G. Vander Heiden, Jianzhu Chen   +13 more
doaj   +1 more source

Gluttony and thermogenesis revisited [PDF]

International Journal of Obesity, 1999
The evolutionary and biological significance of adaptive, homeostatic forms of heat production (thermogenesis) is reviewed. After summarizing the role and selective value of thermogenesis in body temperature regulation (shivering and non-shivering thermogenesis) and the febrile response to infection (fever), the review concentrates on diet-induced ...
openaire   +3 more sources

Central control of brown adipose tissue thermogenesis

Frontiers in Endocrinology, 2012
Thermogenesis, the production of heat energy, is an essential component of the homeostatic repertoire to maintain body temperature during the challenge of low environmental temperature and plays a key role in elevating body temperature during the febrile
Shaun F. Morrison, Christopher J. Madden, Domenico eTupone   +2 more
doaj   +1 more source

DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-γ production

Nature Communications, 2021
Adipose tissue-resident T cells are known to regulate thermogenesis and energy expenditure. Here the authors report that deletion of mitochondria-localized protein DsbA-L in T cells promotes diet-induced thermogenesis via suppressing IFN-γ production.
Haiyan Zhou, Xinyi Peng, Jie Hu, Liwen Wang, Hairong Luo, Junyan Zhang, Yacheng Zhang, Guobao Li, Yujiao Ji, Jingjing Zhang, Juli Bai, Meilian Liu, Zhiguang Zhou, Feng Liu   +13 more
doaj   +1 more source

Is thermogenesis really needed for brown adipose tissue–mediated metabolic benefit?

The Journal of Clinical Investigation, 2022
Brown adipose tissue (BAT) dissipates energy in the form of heat and functions as a metabolic sink for lipids, glucose, and branched-chain amino acids. Enhanced BAT thermogenesis is thought to tightly couple with beneficial energy metabolism. However, in
Jin-Seon Yook, Shingo Kajimura
doaj   +1 more source

SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice

Nature Communications, 2022
Sirtuins have been reported to positively regulate brown adipose tissue thermogenesis. Here the authors report that brown adipocytic SIRT7 suppresses whole-body energy expenditure and thermogenesis in mice, potentially by attenuating batokine gene ...
Tatsuya Yoshizawa, Yoshifumi Sato, Shihab U. Sobuz, Tomoya Mizumoto, Tomonori Tsuyama, Md. Fazlul Karim, Keishi Miyata, Masayoshi Tasaki, Masaya Yamazaki, Yuichi Kariba, Norie Araki, Eiichi Araki, Shingo Kajimura, Yuichi Oike, Thomas Braun, Eva Bober, Johan Auwerx, Kazuya Yamagata   +17 more
doaj   +1 more source

3,5-Diiodo-L-thyronine activates brown adipose tissue thermogenesis in hypothyroid rats. [PDF]

PLoS ONE, 2015
3,5-Diiodo-l-thyronine (T2), a thyroid hormone derivative, is capable of increasing energy expenditure, as well as preventing high fat diet-induced overweight and related metabolic dysfunction.
Assunta Lombardi, Rosalba Senese, Rita De Matteis, Rosa Anna Busiello, Federica Cioffi, Fernando Goglia, Antonia Lanni   +6 more
doaj   +1 more source

Adaptive thermogenesis in humans [PDF]

International Journal of Obesity, 2010
The increasing prevalence of obesity and its comorbidities reflects the interaction of genes that favor the storage of excess energy as fat with an environment that provides ad libitum availability of energy-dense foods and encourages an increasingly sedentary lifestyle.
Rudolph L. Leibel, Michael Rosenbaum
openaire   +3 more sources

Chemogenetic Excitation of Ventromedial Hypothalamic Steroidogenic Factor 1 (SF1) Neurons Increases Muscle Thermogenesis in Mice

Biomolecules
Allostatic adaptations to a perceived threat are crucial for survival and may tap into mechanisms serving the homeostatic control of energy balance. We previously established that exposure to predator odor (PO) in rats significantly increases skeletal ...
Christina A. Watts, Jordan Smith, Roman Giacomino, Dinah Walter, Guensu Jang, Aalia Malik, Nicholas Harvey, Colleen M. Novak   +7 more
doaj   +1 more source

At thermoneutrality, acute thyroxine-induced thermogenesis and pyrexia are independent of UCP1

Molecular Metabolism, 2019
Objective: Hyperthyroidism is associated with increased metabolism (“thyroid thermogenesis”) and elevated body temperature, often referred to as hyperthermia.
Claudia Dittner, Erik Lindsund, Barbara Cannon, Jan Nedergaard   +3 more
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