Results 41 to 50 of about 85,969 (275)

Water-Induced Thermogenesis [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2003
Drinking lots of water is commonly espoused in weight loss regimens and is regarded as healthy; however, few systematic studies address this notion. In 14 healthy, normal-weight subjects (seven men and seven women), we assessed the effect of drinking 500 ml of water on energy expenditure and substrate oxidation rates by using whole-room indirect ...
Michael, Boschmann, Jochen, Steiniger, Uta, Hille, Jens, Tank, Frauke, Adams, Arya M, Sharma, Susanne, Klaus, Friedrich C, Luft, Jens, Jordan   +8 more
openaire   +2 more sources

ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP

Nature Metabolism, 2022
Noradrenaline (NA) regulates cold-stimulated adipocyte thermogenesis1. Aside from cAMP signalling downstream of β-adrenergic receptor activation, how NA promotes thermogenic output is still not fully understood.
Janane F. Rahbani, Charlotte Scholtes, Damien Lagarde, M. F. Hussain, Anna Roesler, Christien B. Dykstra, Jakub Bunk, B. Samborska, S. O’Brien, Emma Tripp, Alain Pacis, Anthony R. Angueira, O. S. Johansen, J. Cinkornpumin, Ishtiaque Hossain, M. Lynes, Yang Zhang, Andrew P. White, William A. Pastor, M. Chondronikola, L. Sidossis, S. Klein, A. Kralli, A. Cypess, S. Pedersen, N. Jessen, Y. Tseng, Zachary Gerhart-Hines, P. Seale, D. Calebiro, V. Giguère, L. Kazak   +31 more
semanticscholar   +1 more source

Gsα deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling

Molecular Metabolism, 2019
Objective: Gsα couples multiple receptors, including the melanocortin 4 receptor (MC4R), to intracellular cAMP generation. Germline inactivating Gsα mutations lead to obesity in humans and mice.
Min Chen, Eric A. Wilson, Zhenzhong Cui, Hui Sun, Yogendra B. Shrestha, Brandon Podyma, Christina H. Le, Benedetta Naglieri, Karel Pacak, Oksana Gavrilova, Lee S. Weinstein   +10 more
doaj   +1 more source

Aqueous extracts of Aconite promote thermogenesis in rats with hypothermia via regulating gut microbiota and bile acid metabolism

Chinese Medicine, 2021
Background Intermittent or prolonged exposure to severe cold stress disturbs energy homeostasis and can lead to hypothermia, heart failure, Alzheimer’s disease, and so on. As the typical “hot” traditional Chinese medicine, Aconite has been widely used to
Juan Liu, Yuzhu Tan, Hui Ao, Wuwen Feng, Cheng Peng   +4 more
doaj   +1 more source

Autonomic regulation of brown adipose tissue thermogenesis in health & disease: Potential clinical applications for altering BAT thermogenesis

Frontiers in Neuroscience, 2014
From mouse to man, brown adipose tissue (BAT) is a significant source of thermogenesis contributing to the maintenance of the body temperature homeostasis during the challenge of low environmental temperature.
Domenico eTupone, Christopher J. Madden, Shaun F. Morrison   +2 more
doaj   +1 more source

Involvement of TRP Channels in Adipocyte Thermogenesis: An Update

Frontiers in Cell and Developmental Biology, 2021
Obesity prevalence became a severe global health problem and it is caused by an imbalance between energy intake and expenditure. Brown adipose tissue (BAT) is a major site of mammalian non-shivering thermogenesis or energy dissipation.
Wuping Sun, Yixuan Luo, Fei Zhang, Shuo Tang, Tao Zhu   +4 more
doaj   +1 more source

Thermal stress induces glycolytic beige fat formation via a myogenic state. [PDF]

, 2019
Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue.
A Jaworski, AA Lans van der, Andrew Brack, Annarita Scaramozza, C Trapnell, Carlos Henrique Sponton, DC Berry, ES Bachman, H Ohno, J Nedergaard, J Sanchez-Gurmaches, J Wu, JR Arch, JZ Long, K Ikeda, K Nishijo, K Shinoda, Kazuki Tajima, Kenji Ikeda, Kosaku Shinoda, Kyeongkyu Kim, L Kazak, L Vishvanath, L Ye, LZ Sharp, M Razzoli, ME Lidell, MJ Hanssen, ML Gantner, MS Rodeheffer, P Cohen, P Seale, Qiang Wang, S Collins, S Heinz, S Jung, S Kajimura, S Tripathi, Shingo Kajimura, T Buch, T Yoneshiro, Takeshi Yoneshiro, VK Mootha, Y Hasegawa, YH Lee, YH Tseng, Yong Chen, Zachary Brown, ZF Yang   +48 more
core   +2 more sources

Violet-light suppression of thermogenesis by Opsin 5 hypothalamic neurons

Nature, 2020
The opsin family of G-protein-coupled receptors are used as light detectors in animals. Opsin 5 (also known as neuropsin or OPN5) is a highly conserved opsin that is sensitive to visible violet light 1 , 2 .
Kevin X. Zhang, Shane P. D’Souza, Brian A. Upton, Stace Kernodle, S. Vemaraju, G. Nayak, Kevin D. Gaitonde, A. Holt, Courtney D. Linne, April N. Smith, Nathan T. Petts, M. Batie, R. Mukherjee, Durgesh Tiwari, Ethan D. Buhr, R. V. Van Gelder, C. Gross, Alison M. Sweeney, J. Sanchez-Gurmaches, R. Seeley, R. Lang   +20 more
semanticscholar   +1 more source

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice [PDF]

, 2012
Insulin resistance and impaired glucose homoeostasis are important indicators of Type 2 diabetes and are early risk factors of AD (Alzheimer's disease).
Alex J. Harper, Alison D. McNeilly, Almind, Arch, Azzu, Balleza-Tapia, Biessels, Burcelin, Butler, Cai, Cannon, Choi, Cioffi, Cole, Craft, Craft, D. Lee Hamilton, David R. Howlett, De Felice, de la Monte, de la Monte, Dominguez, Folch, Fromme, Frölich, Fukumoto, Harrison, Hassing, Ho, Huse, Ishrut Hussain, Janson, Jennifer Gallagher, John R. Speakman, Judy Latcham, Kirsten A. Bannon, Kobayashi, Kontani, Kus, LaFerla, Laura A. Burgess, Lee, Li, Lobke M. Vaanholt, Luchsinger, Luo, Mensink, Michael L.J. Ashford, Mirshamsi, Paul J. Meakin, Pietrak, Rapoport, Rivera, Roberds, Sankaranarayanan, Selman, Speakman, Steen, Tiraby, Vassar, Vassar, Vattemi, Xie   +62 more
core   +4 more sources

IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis.

Journal of Clinical Investigation, 2021
Adipose thermogenesis is repressed in obesity, reducing the homeostatic capacity to compensate for chronic overnutrition. Inflammation inhibits adipose thermogenesis, but little is known about how this occurs.
Shuai Yan, M. Kumari, Haopeng Xiao, Christopher Jacobs, Shihab Kochumon, Mark P. Jedrychowski, Edward T. Chouchani, R. Ahmad, E. Rosen   +8 more
semanticscholar   +1 more source