Results 51 to 60 of about 65,191 (322)

Latest advances in the regulatory genes of adipocyte thermogenesis

Frontiers in Endocrinology, 2023
An energy imbalance cause obesity: more energy intake or less energy expenditure, or both. Obesity could be the origin of many metabolic disorders, such as type 2 diabetes and cardiovascular disease.
Tao Nie, Jinli Lu, Hua Zhang, Liufeng Mao   +3 more
doaj   +1 more source

Single cell analysis reveals immune cell-adipocyte crosstalk regulating the transcription of thermogenic adipocytes. [PDF]

, 2019
Immune cells are vital constituents of the adipose microenvironment that influence both local and systemic lipid metabolism. Mice lacking IL10 have enhanced thermogenesis, but the roles of specific cell types in the metabolic response to IL10 remain to ...
Ahn, In Sook, Arneson, Douglas, Diamante, Graciel, Feng, An-Chieh, Hart, Sydney K, Lee, Stephen D, Rajbhandari, Abha K, Rajbhandari, Prashant, Reue, Karen, Santos, Luis C, Smale, Stephen T, Thomas, Brandon J, Tontonoz, Peter, Vergnes, Laurent, Yang, Xia, Zaghari, Nima   +15 more
core   +1 more source

Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK [PDF]

, 2014
Copyright © 2014 Elsevier Inc.
Bisschop, Peter H., Dieguez, Carlos, Fernandez-Mallo, Diana, Fliers, Eric, Gallego, Rosalia, Gonzalez-Garcia, Ismael, Kalsbeek, Andries, Lage, Ricardo, Liu, Ji, Lopez, Miguel, Martinez De Morentin, Pablo Blanco, Martinez-Sanchez, Noelia, Martins, Luis, Morgan, Donald A, Nogueiras, Ruben, Pinilla, Leonor, Rahmouni, Kamal, Ruiz-Pino, Francisco, Saha, Asish K, Tena-Sempere, Manuel   +19 more
core   +4 more sources

Gluttony and thermogenesis revisited [PDF]

International Journal of Obesity, 1999
The evolutionary and biological significance of adaptive, homeostatic forms of heat production (thermogenesis) is reviewed. After summarizing the role and selective value of thermogenesis in body temperature regulation (shivering and non-shivering thermogenesis) and the febrile response to infection (fever), the review concentrates on diet-induced ...
openaire   +3 more sources

The Long Noncoding RNA ΒFaar Promotes White Adipose Tissue Browning and Prevents Diet‐Induced Obesity

Advanced Science, EarlyView.
βFaar selectively targets and inhibits the GTPase activity of the RAB18 protein, thereby reducing LD volume. Conversely, βFaar promotes nuclear translocation of the transcription factor IRF4 in inguinal white adipose tissue (iWAT), facilitating the browning of white adipose tissue and attenuating body fat accumulation.
Yue Yang, Bin Huang, Baixue Sha, Danni Gao, Yimeng Qin, Ziyi Li, Xi Chen, Yinuo Jin, Yi Pan, Yanfeng Zhang, Yumeng Shen, Yu Liu, Liang Jin, Fangfang Zhang   +13 more
wiley   +1 more source

Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation

Molecular Metabolism, 2022
Objective: Genome-wide association studies identified ORMDL3 as an obesity-related gene, and its expression was negatively correlated with body mass index.
Yu Song, Wenying Zan, Liping Qin, Shuang Han, Lili Ye, Molin Wang, Baichun Jiang, Pan Fang, Qiji Liu, Changshun Shao, Yaoqin Gong, Peishan Li   +11 more
doaj  

Oxidative Phosphorylation in Uncoupled Mitochondria

BioEssays, EarlyView.
Brown adipose tissue (BAT) mediates non‐shivering thermogenesis (NST) through activation of uncoupling protein 1 (UCP1). Due to the uncoupled nature of BAT, oxidative phosphorylation is an underappreciated contributor to NST. Here, we discuss the implications of Inhibitory Factor 1 modulation, an endogenous inhibitor of ATP synthase, for BAT physiology.
Henver S. Brunetta, Marcelo A. Mori, Alexander Bartelt   +2 more
wiley   +1 more source

The Raphe Pallidus and the Hypothalamic-Pituitary-Thyroid Axis Gate Seasonal Changes in Thermoregulation in the Hibernating Arctic Ground Squirrel (Urocitellus parryii)

Frontiers in Physiology, 2018
Thermoregulation is necessary to maintain energy homeostasis. The novel discovery of brown adipose tissue (BAT) in humans has increased research interests in better understanding BAT thermogenesis to restore energy balance in metabolic disorders.
Carla Frare, Carla Frare, Mackenzie E. Jenkins, Steven J. Soldin, Steven J. Soldin, Kelly L. Drew, Kelly L. Drew   +6 more
doaj   +1 more source

Integrated gene expression profiles reveal a transcriptomic network underlying the thermogenic response in adipose tissue

Scientific Reports, 2023
Obesity and type 2 diabetes are two closely related diseases representing a serious threat worldwide. An increase in metabolic rate through enhancement of non-shivering thermogenesis in adipose tissue may represent a potential therapeutic strategy ...
Jordi Rodó, Miquel Garcia, Estefania Casana, Sergio Muñoz, Claudia Jambrina, Victor Sacristan, Sylvie Franckhauser, Ignasi Grass, Veronica Jimenez, Fatima Bosch   +9 more
doaj   +1 more source

Alpha- and beta-adrenergic mediation of changes in metabolism and Na/K exchange in rat brown fat [PDF]

, 1985
Double- and triple-barreled ion-sensitive microelectrodes were used to measure changes in extracellular K+ and Na+ concentrations ([K+]o, [Na+]o) in brown fat.
Coles, Jonathan A., Girardier, Lucien, Schneider-Picard, Gisela   +2 more
core   +2 more sources