Results 51 to 60 of about 85,969 (275)

The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms [PDF]

, 2015
Objectives: The corticotrophin-releasing factor (CRF)/urocortin system is expressed in the adipose tissue of mammals, but its functional role in this tissue remains unknown.
Clark, S., Contarino, A., Cota, D., Diz-Chaves, Y., Fanelli, F., Grammatopoulos, Dimitris, Lehnert, Hendrik, Lu, B., Markovic, Danijela, Penicaud, L., Tabarin, A.   +10 more
core   +3 more sources

PexRAP inhibits PRDM16-mediated thermogenic gene expression [PDF]

, 2017
How the nuclear receptor PPARγ regulates the development of two functionally distinct types of adipose tissue, brown and white fat, as well as the browning of white fat, remains unclear.
Dean, John M, Feng, Chu, He, Anyuan, Hsu, Fong-Fu, Lodhi, Irfan J, Park, Hongsuk, Semenkovich, Clay F, Song, Haowei, Tan, Min   +8 more
core   +3 more sources

UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis

Nature Medicine, 2017
Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-independent thermogenic mechanism in beige fat that involves enhanced ATP-dependent ...
K. Ikeda, Qianqian Kang, T. Yoneshiro, J. Camporez, Hiroko Maki, M. Homma, Kosaku Shinoda, Yong Chen, Xiaodan Lu, Pema Maretich, Kazuki Tajima, K. Ajuwon, T. Soga, S. Kajimura   +13 more
semanticscholar   +1 more source

Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling

Nature Communications, 2018
Excess caloric intake leads to increased thermogenesis in brown adipose tissue, to limit weight gain. Here, the authors show that neuropeptide FF receptor-2 signalling promotes thermogenesis via control of NPY expression in the arcuate nucleus, and that ...
Lei Zhang, Chi Kin Ip, I-Chieh J. Lee, Yue Qi, Felicia Reed, Tim Karl, Jac Kee Low, Ronaldo F. Enriquez, Nicola J. Lee, Paul A. Baldock, Herbert Herzog   +10 more
doaj   +1 more source

Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction via leptin-mediated AMPKα/STAT3 signaling in diet-induced obesity

Theranostics, 2020
Background: Activation of the thermogenic program in white and brown adipocytes presents a promising avenue for increasing energy expenditure during the treatment of obesity.
Yu Xu, Ning Wang, H. Tan, Sha Li, Cheng Zhang, Zhangjin Zhang, Yibin Feng   +6 more
semanticscholar   +1 more source

Mitochondrial H+ Leak and Thermogenesis.

Annual Review of Physiology, 2021
Mitochondria of all tissues convert various metabolic substrates into two forms of energy: ATP and heat. Historically, the primary focus of research in mitochondrial bioenergetics was on the mechanisms of ATP production, while mitochondrial thermogenesis
A. Bertholet, Yuriy Kirichok
semanticscholar   +1 more source

Glucocorticoid Receptor and Adipocyte Biology. [PDF]

, 2018
Glucocorticoids are steroid hormones that play a key role in metabolic adaptations during stress, such as fasting and starvation, in order to maintain plasma glucose levels.
Harris, Charles A, Lee, Rebecca A, Wang, Jen-Chywan   +2 more
core   +2 more sources

Brown Adipose Tissue, Diet-Induced Thermogenesis, and Thermogenic Food Ingredients: From Mice to Men

Frontiers in Endocrinology, 2020
Since the recent rediscovery of brown adipose tissue (BAT) in adult humans, this thermogenic tissue has been attracting increasing interest. The inverse relationship between BAT activity and body fatness suggests that BAT, because of its energy ...
M. Saito, Mami Matsushita, T. Yoneshiro, Y. Okamatsu-Ogura   +3 more
semanticscholar   +1 more source

Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis

Nature Communications, 2021
The energy-dissipating capacity of brown adipose tissue through thermogenesis can be targeted to improve energy balance. Mammalian 5′-AMP-activated protein kinase, a key nutrient sensor for maintaining cellular energy status, is a known therapeutic ...
Wendong Huang, Eryun Zhang, Lihua Jin, Yangmeng Wang, Jui Tu, Lili Ding, Zhipeng Fang, Mingjie Fan, I. Al-Abdullah, R. Natarajan, K. Ma, Zhengtao Wang, A. Riggs, Li Yang   +13 more
semanticscholar   +1 more source

Thermogenesis in Birds

Bioscience Reports, 2001
The article discusses the importance of avian skeletal muscle as a source for heat generation by means of both shivering and non-shivering. Non-shivering thermogenesis in birds is still a polemic issue. Recent evidence at the molecular/cellular level indicates, however, that this type of heat generation may also exist among birds.
J E, Bicudo, C R, Vianna, J G, Chaui-Berlinck   +2 more
openaire   +2 more sources