Results 51 to 60 of about 33,124 (202)

Citrus aurantium L. polymethoxyflavones promote thermogenesis of brown and white adipose tissue in high-fat diet induced C57BL/6J mice

Journal of Functional Foods, 2020
Promoting thermogenesis of brown and beige adipocytes increases energy expenditure, which is a critical approach to prevent obesity. In the present study, we elucidated the effect of the citrus polymethoxyflavones on adaptive thermogenesis in high fat ...
Guangning Kou, Yan Hu, Zixiao Jiang, Zhenqing Li, Peiyuan Li, Hongjie Song, Qiyang Chen, Zhiqin Zhou, Quanjun Lyu   +8 more
doaj  

microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity

Nature Communications, 2021
Adaptive thermogenesis is regulated by central neuronal circuits. Here, the authors show that microRNA-33 in the brain contributes to the maintenance of brown adipose tissue thermogenesis and whole-body energy balance via enhanced sympathetic nerve tone,
Takahiro Horie, Tetsushi Nakao, Yui Miyasaka, Tomohiro Nishino, Shigenobu Matsumura, Fumiko Nakazeki, Yuya Ide, Masahiro Kimura, Shuhei Tsuji, Randolph Ruiz Rodriguez, Toshimitsu Watanabe, Tomohiro Yamasaki, Sijia Xu, Chiharu Otani, Sawa Miyagawa, Kazuki Matsushita, Naoya Sowa, Aoi Omori, Jin Tanaka, Chika Nishimura, Masataka Nishiga, Yasuhide Kuwabara, Osamu Baba, Shin Watanabe, Hitoo Nishi, Yasuhiro Nakashima, Marina R. Picciotto, Haruhisa Inoue, Dai Watanabe, Kazuhiro Nakamura, Tsutomu Sasaki, Takeshi Kimura, Koh Ono   +32 more
doaj   +1 more source

Murburn scheme for thermogenesis mediated by uncoupling protein [PDF]

arXiv, 2018
Thermogenesis by uncoupling protein (UCP) has traditionally been explained as the dissipation of proton gradient across the inner mitochondrial membrane into heat. Herein, we propose that UCPs, aided by the large pore and positively charged amino acids of suspended loops, enable protonation and transport of DROS.
arxiv  

The Liver as a Hub in Thermogenesis [PDF]

Cell Metabolism, 2017
Manipulating thermogenesis could increase energy expenditure and improve metabolism. Brown fat is a major site of nonshivering thermogenesis, but other tissues, notably muscle and liver, can contribute to cold adaptation. In this issue, Simcox et al.
openaire   +3 more sources

Gsα deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling

Molecular Metabolism, 2019
Objective: Gsα couples multiple receptors, including the melanocortin 4 receptor (MC4R), to intracellular cAMP generation. Germline inactivating Gsα mutations lead to obesity in humans and mice.
Min Chen, Eric A. Wilson, Zhenzhong Cui, Hui Sun, Yogendra B. Shrestha, Brandon Podyma, Christina H. Le, Benedetta Naglieri, Karel Pacak, Oksana Gavrilova, Lee S. Weinstein   +10 more
doaj  

A remote response of ATP hydrolysis [PDF]

arXiv, 2013
ATP-hydrolysis is the basic energy source of many physiological processes, but there is a lack of knowledge regarding its biological role other than energy transfer and thermogenesis. Not all the energy released by ATP-hydrolysis could be used in powering target biological processes and functions. Partial energy dissipates into water. By validating the
arxiv  

Potential of Traditional Medicinal Plants for Treating Obesity: A Review [PDF]

2012 International Conference on Nutrition and Food Sciences, IPCBEE vol. 39 (2012) IACSIT Press, Singapore, 2012
Obesity is a global health concern associated with high morbidity and mortality. Therapeutic strategies include synthetic drugs and surgery, which may entail high costs and serious complications. Plant-based medicinal agents offer an alternative approach.
arxiv  

Fundamental mechanisms of thermogenesis

Comptes Rendus. Biologies, 2006
Thermogenesis is an obligatory consequence of cellular metabolism and is identified as a unique property of homeotherms which have to maintain constant their body temperature in a cold environment. Physiologically, thermogenesis is made of basal metabolism, post-prandial thermogenesis, exercise-induced thermogenesis and adaptive thermogenesis induced ...
openaire   +4 more sources

Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis

eLife, 2020
Brown adipose tissue (BAT) is composed of thermogenic cells that convert chemical energy into heat to maintain a constant body temperature and counteract metabolic disease.
Vanja Panic, Stephanie Pearson, James Banks, Trevor S Tippetts, Jesse N Velasco-Silva, Sanghoon Lee, Judith Simcox, Gisela Geoghegan, Claire L Bensard, Tyler van Ry, Will L Holland, Scott A Summers, James Cox, Gregory S Ducker, Jared Rutter, Claudio J Villanueva   +15 more
doaj   +1 more source

Sympathetic nerve innervation is required for beigeing in white fat

Physiological Reports, 2019
It is increasingly recognized that activation of beige adipocyte thermogenesis by pharmacological or genetic approaches increases energy expenditure and alleviates obesity.
Qiang Cao, Jia Jing, Xin Cui, Hang Shi, Bingzhong Xue   +4 more
doaj   +1 more source