Results 51 to 60 of about 83,845 (311)

snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis

Nature, 2020
Adipose tissue is usually classified on the basis of its function as white, brown or beige (brite) 1 . It is an important regulator of systemic metabolism, as shown by the fact that dysfunctional adipose tissue in obesity leads to a variety of secondary ...
Wenfei Sun, H. Dong, Miroslav Baláž, M. Slyper, Eugene Drokhlyansky, G. Colleluori, A. Giordano, Z. Kovaničová, P. Stefanicka, Lucia Balazova, L. Ding, A. Husted, G. Rudofsky, J. Ukropec, S. Cinti, T. Schwartz, A. Regev, C. Wolfrum   +17 more
semanticscholar   +1 more source

Glucocorticoid Receptor and Adipocyte Biology. [PDF]

, 2018
Glucocorticoids are steroid hormones that play a key role in metabolic adaptations during stress, such as fasting and starvation, in order to maintain plasma glucose levels.
Harris, Charles A, Lee, Rebecca A, Wang, Jen-Chywan   +2 more
core   +2 more sources

The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue

Nature Communications, 2021
Obesity results from a caloric imbalance between energy intake, absorption and expenditure. In both rodents and humans, diet-induced thermogenesis contributes to energy expenditure and involves the activation of brown adipose tissue (BAT). We hypothesize
Bo Wang, E. Tsakiridis, Shuman Zhang, A. Llanos, Eric M. Desjardins, Julian M. Yabut, Alexander E Green, Emily A. Day, Brennan K Smith, J. Lally, Jianhan Wu, A. Raphenya, Krishna A Srinivasan, A. McArthur, S. Kajimura, J. S. Patel, M. Wade, K. Morrison, A. Holloway, G. Steinberg   +19 more
semanticscholar   +1 more source

Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling

Nature Communications, 2018
Excess caloric intake leads to increased thermogenesis in brown adipose tissue, to limit weight gain. Here, the authors show that neuropeptide FF receptor-2 signalling promotes thermogenesis via control of NPY expression in the arcuate nucleus, and that ...
Lei Zhang, Chi Kin Ip, I-Chieh J. Lee, Yue Qi, Felicia Reed, Tim Karl, Jac Kee Low, Ronaldo F. Enriquez, Nicola J. Lee, Paul A. Baldock, Herbert Herzog   +10 more
doaj   +1 more source

PexRAP inhibits PRDM16-mediated thermogenic gene expression [PDF]

, 2017
How the nuclear receptor PPARγ regulates the development of two functionally distinct types of adipose tissue, brown and white fat, as well as the browning of white fat, remains unclear.
Dean, John M, Feng, Chu, He, Anyuan, Hsu, Fong-Fu, Lodhi, Irfan J, Park, Hongsuk, Semenkovich, Clay F, Song, Haowei, Tan, Min   +8 more
core   +3 more sources

RNA-binding protein YBX3 promotes PPARγ-SLC3A2 mediated BCAA metabolism fueling brown adipogenesis and thermogenesis

Molecular Metabolism
Objective: Activating brown adipose tissue (BAT) thermogenesis is a promising approach to combat obesity and metabolic disorders. The post-transcriptional regulation of BAT thermogenesis mediated by RNA-binding proteins (RBPs) is still not fully ...
Lin-Yun Chen, Li-Wen Wang, Jie Wen, Jing-Dong Cao, Rui Zhou, Jin-Lin Yang, Ye Xiao, Tian Su, Yan Huang, Qi Guo, Hai-Yan Zhou, Xiang-Hang Luo, Xu Feng   +12 more
doaj   +1 more source

BCAA nitrogen flux in brown fat controls metabolic health independent of thermogenesis

Cell
SUMMARY Brown adipose tissue (BAT) is best known for thermogenesis. Rodent studies demonstrated that enhanced BAT thermogenesis is tightly associated with increased energy expenditure, reduced body-weight, and improved glucose homeostasis. However, human
Anthony R. P. Verkerke, Dandan Wang, Naofumi Yoshida, Zachary H Taxin, Xu Shi, Shuning Zheng, Yuka Li, Christopher Auger, Satoshi Oikawa, Jin-Seon Yook, Melia Granath-Panelo, Wentao He, Guo-fang Zhang, Mami Matsushita, Masayuki Saito, R. Gerszten, E. Mills, Alexander S. Banks, Yasushi Ishihama, P. White, R. McGarrah, T. Yoneshiro, S. Kajimura   +22 more
semanticscholar   +1 more source

Thermogenesis in Birds

Bioscience Reports, 2001
The article discusses the importance of avian skeletal muscle as a source for heat generation by means of both shivering and non-shivering. Non-shivering thermogenesis in birds is still a polemic issue. Recent evidence at the molecular/cellular level indicates, however, that this type of heat generation may also exist among birds.
J E, Bicudo, C R, Vianna, J G, Chaui-Berlinck   +2 more
openaire   +2 more sources

QPLOT Neurons—Converging on a Thermoregulatory Preoptic Neuronal Population

Frontiers in Neuroscience, 2021
The preoptic area of the hypothalamus is a homeostatic control center. The heterogeneous neurons in this nucleus function to regulate the sleep/wake cycle, reproduction, thirst and hydration, as well as thermogenesis and other metabolic responses ...
Brian A. Upton, Brian A. Upton, Brian A. Upton, Brian A. Upton, Shane P. D’Souza, Shane P. D’Souza, Shane P. D’Souza, Richard A. Lang, Richard A. Lang, Richard A. Lang, Richard A. Lang   +10 more
doaj   +1 more source

Repeatability of brown adipose tissue measurements on FDG PET/CT following a simple cooling procedure for BAT activation [PDF]

, 2019
Brown Adipose Tissue (BAT) is present in a significant number of adult humans and can be activated by exposure to cold. Measurement of active BAT presence, activity, and volume are desirable for determining the efficacy of potential treatments intended ...
Crandall, John P, Gajwani, Prateek, Mawhinney, Daniel D, O., Joo H, Sterzer, Fred, Wahl, Richard L   +5 more
core   +2 more sources