Results 81 to 90 of about 83,845 (311)

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source

The Raphe Pallidus and the Hypothalamic-Pituitary-Thyroid Axis Gate Seasonal Changes in Thermoregulation in the Hibernating Arctic Ground Squirrel (Urocitellus parryii)

Frontiers in Physiology, 2018
Thermoregulation is necessary to maintain energy homeostasis. The novel discovery of brown adipose tissue (BAT) in humans has increased research interests in better understanding BAT thermogenesis to restore energy balance in metabolic disorders.
Carla Frare, Carla Frare, Mackenzie E. Jenkins, Steven J. Soldin, Steven J. Soldin, Kelly L. Drew, Kelly L. Drew   +6 more
doaj   +1 more source

Single cell analysis reveals immune cell-adipocyte crosstalk regulating the transcription of thermogenic adipocytes. [PDF]

, 2019
Immune cells are vital constituents of the adipose microenvironment that influence both local and systemic lipid metabolism. Mice lacking IL10 have enhanced thermogenesis, but the roles of specific cell types in the metabolic response to IL10 remain to ...
Ahn, In Sook, Arneson, Douglas, Diamante, Graciel, Feng, An-Chieh, Hart, Sydney K, Lee, Stephen D, Rajbhandari, Abha K, Rajbhandari, Prashant, Reue, Karen, Santos, Luis C, Smale, Stephen T, Thomas, Brandon J, Tontonoz, Peter, Vergnes, Laurent, Yang, Xia, Zaghari, Nima   +15 more
core   +1 more source

Adipocyte Liver Kinase b1 Suppresses Beige Adipocyte Renaissance Through Class IIa Histone Deacetylase 4. [PDF]

, 2017
Uncoupling protein 1+ beige adipocytes are dynamically regulated by environment in rodents and humans; cold induces formation of beige adipocytes, whereas warm temperature and nutrient excess lead to their disappearance. Beige adipocytes can form through
Chawla, Ajay, Huang, Wendong, Paulo, Esther, Wang, Biao, Wang, Yangmeng, Wu, Dongmei, Wu, Yixuan   +6 more
core   +1 more source

Aifm2, a NADH Oxidase, Supports Robust Glycolysis and Is Required for Cold- and Diet-Induced Thermogenesis.

Molecules and Cells, 2020
Brown adipose tissue (BAT) is highly metabolically active tissue that dissipates energy via UCP1 as heat, and BAT mass is correlated negatively with obesity.
Hai P. Nguyen, Danielle Yi, Frances Lin, J. Viscarra, Chihiro Tabuchi, Katina Ngo, Gawon Shin, Angus Y. Lee, Yuhui Wang, H. Sul   +9 more
semanticscholar   +1 more source

Steroids and thermogenesis

Physiological Research, 2006
Apart from thyroid hormones, as the main hormonal regulators of obligatory thermogenesis, and catecholamines, as major hormonal regulators of facultative thermogenesis, production of heat in homeotherms can also be influenced by steroids. Generally, hormones can influence heat production by regulating the activity of various enzymes of oxidative ...
R, Hampl, L, Stárka, L, Janský
openaire   +2 more sources

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Microbial thermogenesis is dependent on ATP concentrations and the protein kinases ArcB, GlnL, and YccC.

PLoS Biology, 2023
Organisms necessarily release heat energy in their pursuit of survival. This process is known as cellular thermogenesis and is implicated in many processes from cancer metabolism to spontaneous farm fires.
Puneet Singh Dhatt, Stephen Chiu, Tae Seok Moon   +2 more
doaj   +1 more source

A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis. [PDF]

, 2016
Beige adipocytes emerge postnatally within the white adipose tissue in response to certain environmental cues, such as chronic cold exposure. Because of its highly recruitable nature and relevance to adult humans, beige adipocytes have gained much ...
Bannai, Makoto, Kajimura, Shingo, Nogusa, Yoshihito, Ohyama, Kana, Shinoda, Kosaku, Suzuki, Katsuya   +5 more
core   +2 more sources

Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats

Animal Models and Experimental Medicine, EarlyView.
Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček, Pavol Boďo, Barbora Kaločayová, Marta Šoltésová Prnová   +3 more
wiley   +1 more source