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Ubiquitin Receptor RPN13 Mediates the Inhibitory Interaction of Diphenyldihaloketones CLEFMA and EF24 With the 26S Proteasome

Frontiers in Chemistry, 2018
The proteasome is a validated target in drug discovery for diseases associated with unusual proteasomal activity. Here we report that two diphenyldihaloketones, CLEFMA and EF24, inhibit the peptidase activity of the 26S proteasome.
Geeta Rao +6 more
doaj +1 more source

Bioactive peptides derived from the enzymatic hydrolysis of cowhide collagen for the potential treatment of atherosclerosis: A computational approach

Intelligent Pharmacy
Cowhide collagen hydrolysates (CCHs) are peptides and amino acids obtained from the partial hydrolysis of collagen. These have numerous potential applications in the food, biomedical, and pharmaceutical industries. The study analyzed the physicochemical,
Hamadou Mamoudou +6 more
doaj +1 more source

Culture of human intestinal epithelial cell using the dissociating enzyme thermolysin and endothelin-3

Brazilian Journal of Medical and Biological Research, 2010
Epithelium, a highly dynamic system, plays a key role in the homeostasis of the intestine. However, thus far a human intestinal epithelial cell line has not been established in many countries.
Z. Liu, P. Zhang, Y. Zhou, H. Qin, T. Shen +4 more
doaj

Hydrophobic interaction in thermolysin specificity [PDF]