Results 21 to 30 of about 26,404 (254)

Synthesis of Oxadiazoles, Thiadiazoles and Triazoles Derived from Benzo[b]thiophene

Molecules, 2005
In this work 3-chloro-2-chlorocarbonylbenzo[b]thiophene (1) was prepared from cinnamic acid and then converted into the acid hydrazide 2. The azomethines 3a-e were prepared from the corresponding aryl aldehydes and the acid hydrazide 2.
N. Rezki, M. Aouad, R. Al-Bayati, A. Sharba   +3 more
doaj   +1 more source

Synthesis, Spectroscopic and Crystal Structure Analysis of 2-(4-Fluorobenzyl)-6-(4-Methoxyphenyl)Imidazo[2,1-B][1,3,4]Thiadiazole and its Morpholinomethyl Derivative [PDF]

, 2013
The preparation of 2-(4-fluorobenzyl)-6-(4-methoxyphenyl)-5-morpholin-1-ylmethyl imidazo[2,1-b][1,3,4]thiadiazole via the intermediate 2-(4-fluorobenzyl)-6-(4-methoxyphenyl)Imidazo[2,1-b][1,3,4] thiadiazole is described.
Afshan Banu, ., Khazi, I.A.M., Noor Shahina Begum, ., Ravi, S.Lamani., Vasundhara, D.E.   +4 more
core   +1 more source

Discovery of Matrinic Thiadiazole Derivatives as a Novel Family of Anti-Liver Fibrosis Agents via Repression of the TGFβ/Smad Pathway

Molecules, 2018
A series of novel matrinic thiadiazole derivatives were designed, synthesized and evaluated for their inhibitory effect on COL1A1 promotor. The SAR indicated that: (i) the introduction of a thiadiazole on the 11-side chain was beneficial for activity ...
Tianyu Niu, Weixiao Niu, Yunyang Bao, Ting Liu, Danqing Song, Yinghong Li, Hongwei He   +6 more
doaj   +1 more source

Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain [PDF]

, 2016
The antiapoptotic protein BCL 2 is overexpressed in several cancers and contributes to prolonged cell survival and chemoresistance, lending itself as an excellent target for cancer therapy.
Anderson, Arkin, Beauchard, Campos, Case, Chiruvella, Cho, Cotter, Dai, Delft, el-Sherbeny, Fedorov, Ferri, Gross, Gutierrez-Puente, Hanada, Iyer, Karki, Kavitha, Kavitha, Kavitha, Khaw, Kirkin, Kitada, Kolluri, Konopleva, Kumar, Lin, Lotem, Marschitz, Mologni, Moorthy, Morris, Nambiar, Nedelkina, Niesen, Oakes, Pan, Pentimalli, Real, Reed, Rosen, Shahabuddin, Shangary, Sharma, Souers, Srivastava, Srivastava, Trott, Vaillant, Vedadi, Vogler, Wang, Wang, Wang, Willis, Wlodkowic, Zhai   +57 more
core   +1 more source

Antiparasitic Behavior of Trifluoromethylated Pyrazole 2-Amino-1,3,4-thiadiazole Hybrids and Their Analogues: Synthesis and Structure-Activity Relationship

Frontiers in Pharmacology, 2020
A series of trifluoromethylated pyrazole thiosemicarbazone, trifluromethylated pyrazole isothiosemicarbazone, and trifluoromethylated pyrazole 2-amino-1,3,4-thiadiazole hybrids were synthesized and evaluated in vitro against the promastigote form of ...
Jeniffer do Nascimento Ascencio Camargo, Karlos Eduardo Pianoski, Mariellen Guilherme dos Santos, Danielle Lazarin-Bidóia, Hélito Volpato, Sidnei Moura, Celso Vataru Nakamura, Fernanda Andreia Rosa   +7 more
doaj   +1 more source

Enhancement of the photochromic switching speed of bithiophene azo dyes [PDF]

, 2012
A series of heteroaryl substituted bithiophene azo dyes in solution were irradiated with visible light to promote the azo E–Z isomerization and then the kinetics of the thermal Z–E back reaction was studied.
Castro, M. Cidália R., Coelho, Paulo J., Fernandes, Sara S. M., Fonseca, A. Maurício C., Raposo, M. Manuela M.   +4 more
core   +1 more source

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

Angewandte Chemie, EarlyView.
Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg, Yurii Dubanych, Spyridon Kosteletos, Taoran Xiao, Martin Neuenschwander, Tillmann Utesch, Michael Lisurek, Carl Öster, Andreas Oder, Carola Seyffarth, Kathrin Bach, Denise‐Liù Gracias Leone, František Filandr, Marc Wegert, Sascha Lange, Henry Sawczyc, Jens Peter von Kries, Christian P. R. Hackenberger, Edgar Specker, Han Sun, Kvido Stříšovský, Adam Lange   +21 more
wiley   +2 more sources

Tetraaza[7]–[15]helicenes Synthesized by Two‐Step Strategy: Length‐Controlled Chiral π‐Systems Exhibiting Amplified Circularly Polarized Luminescence

Angewandte Chemie, EarlyView.
A modular two‐step strategy provides tetraaza[n]helicenes (n = 7–15) as a homologous series with tunable photophysical and chiroptical properties. Extension beyond n = 11 induces pronounced through‐space π–π interactions, narrowing the energy gap and amplifying circularly polarized luminescence.
Takashi Otani, Yuchen Wu, Kohei Ueda, Yuki Ikeda, Yuna Tada, Natsuna Kinoshita, Takanori Shibata   +6 more
wiley   +2 more sources

Synthesis of Some Novel Thiadiazole Derivative Compounds and Screening Their Antidepressant-Like Activities

Molecules, 2018
Novel thiadiazole derivatives were synthesized through the reaction of acetylated 2-aminothiadiazole and piperazine derivatives. The chemical structures of the compounds were clarified by Infrared Spectroscopy (IR), 1H Nuclear Magnetic Resonance ...
Nafiz Öncü Can, Özgür Devrim Can, Derya Osmaniye, Ümide Demir Özkay   +3 more
doaj   +1 more source

Synthesis and properties of some S-derivatives of 4-phenyl-5-((5-phenylamino-1,3,4-thiadiazole-2-ylthio)methyl)-1,2,4-triazole-3-thione

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019
Studies in the field of chemistry and pharmacology of derivatives of thiadiazole and 1,2,4-triazole are promising and relevant, which is associated with significant success in creating new drugs based on them. The combination of these heterocycles in one
A. S. Hotsulia, S. O. Fedotov
doaj   +1 more source