Results 21 to 30 of about 27,190 (294)

Synthesis and characterization of FeCuAlO₄ as a reusable heterogeneous acidic nanocatalyst for preparation of 2-amino-1,3,4-thiadiazole derivatives in water. [PDF]

Sci Rep
Nikoo A.
europepmc   +3 more sources

Anticancer Activity of Triazolo-Thiadiazole Derivatives and Inhibition of AKT1 and AKT2 Activation

Pharmaceutics, 2021
The fusion of 1,2,4-triazole and 1,3,4-thiadiazole rings results in a class of heterocycles compounds with an extensive range of pharmacological properties.
Dimitrios T. Trafalis, Sofia Sagredou, Panayiotis Dalezis, Maria Voura, Stella Fountoulaki, Nikolaos Nikoleousakos, Konstantinos Almpanakis, Maria V. Deligiorgi, Vasiliki Sarli   +8 more
doaj   +1 more source

Design, Synthesis, Antibacterial Evaluations and In Silico Studies of Novel Thiosemicarbazides and 1,3,4-Thiadiazoles

Molecules, 2022
The emergence of drug-resistant bacterial strains continues to be one of the major challenges of medicine. For this reason, the importance of searching for novel structures of antibacterial drugs chemically different from the currently known antibiotics ...
Sara Janowska, D. Khylyuk, Sylwia Andrzejczuk, M. Wujec   +3 more
semanticscholar   +1 more source

Green Chemistry in Organic Synthesis: Recent Update on Green Catalytic Approaches in Synthesis of 1,2,4-Thiadiazoles

Catalysts, 2022
Green (sustainable) chemistry provides a framework for chemists, pharmacists, medicinal chemists and chemical engineers to design processes, protocols and synthetic methodologies to make their contribution to the broad spectrum of global sustainability ...
Laila Rubab, A. Anum, S. Al-Hussain, Ali Irfan, Sahar Ahmad, S. Ullah, Aamal A. Al-Mutairi, M. Zaki   +7 more
semanticscholar   +1 more source

Synthesis and Molecular Docking Studies of New Series of Bis-Schiff Bases Thiadiazoles Derived From Disulfides and Thioethers with Potent Antibacterial Properties

Science Journal of University of Zakho, 2022
Two new series of various heterocyclic bis-Schiff bases of Thiadiazoles disulfides and thioethers are synthesized. The first series was the synthesis of bis-Schiff of thiadiazole disulfides (4a-h) synthesized from their corresponding Schiff bases after ...
Hardi Q. Hamad, Salam G. Taher, D. Aziz
semanticscholar   +1 more source

New Heparanase-Inhibiting Triazolo-Thiadiazoles Attenuate Primary Tumor Growth and Metastasis

Cancers, 2021
Simple Summary Heparanase is an endoglycosidase that plays a critical role in tumor progression and metastasis. The expression of heparanase in the tumor microenvironment is positively correlated with the aggressiveness of the tumor and is associated ...
Uri Barash, S. Rangappa, C. D. Mohan, Divakar Vishwanath, I. Boyango, Basappa Basappa, I. Vlodavsky, K. Rangappa   +7 more
semanticscholar   +1 more source

Synthesis and antitumor properties of some new 3-R-6-(5-arylfuran-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles

Фармацевтичний журнал, 2021
One of the promising methods of creating antitumor drugs is the screening of potential antitumor agents among synthesized compounds. Nitrogen-based heterocycle analogues are an extremely important class of organic substances that are widely used in ...
I. І. Myrko, Yu. І. Horak, T. I. Chaban, І. V. Drapak, V. S. Matiychuk   +4 more
doaj   +1 more source

Co-crystalization and in vitro biological characterization of 5-Aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors [PDF]

, 2012
A potential therapeutic strategy for targeting cancer that has gained much interest is the inhibition of the ATP binding and ATPase activity of the molecular chaperone Hsp90.
Chrisostomos Prodromou, Daumantas Matulis, Egidijus Kazlauskas, Inga Čikotienė, Paul Workman, S. Mark Roe, Swee Y. Sharp, Wenqing Xu   +7 more
core   +6 more sources

Synthetic Transformations and Medicinal Significance of 1,2,3-Thiadiazoles Derivatives: An Update

Applied Sciences, 2021
The 1,2,3-thiadiazole moiety occupies a significant and prominent position among privileged heterocyclic templates in the field of medicine, pharmacology and pharmaceutics due to its broad spectrum of biological activities.
Ali Irfan, S. Ullah, A. Anum, Nazish Jabeen, A. F. Zahoor, Hafza Kanwal, Katarzyna Kotwica-Mojzych, M. Mojzych   +7 more
semanticscholar   +1 more source

Design, synthesis, and biological evaluation of thiazole/thiadiazole carboxamide scaffold-based derivatives as potential c-Met kinase inhibitors for cancer treatment

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
As part of our continuous efforts to discover novel c-Met inhibitors as antitumor agents, four series of thiazole/thiadiazole carboxamide-derived analogues were designed, synthesised, and evaluated for the in vitro activity against c-Met and four human ...
Xiang Nan, Qiu-Xu Wang, Shao-Jun Xing, Zhi-Gang Liang   +3 more
doaj   +1 more source