Results 41 to 50 of about 4,281 (225)

Heterocyclizations based on N-(R-hydrazine-1-carbonothioyl)cycloalkancarboxamides: functionalized azoles and their antimicrobial activity

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022
Synthesis and structural modification of azoles remains an important area of medical chemistry and allows to obtain new compounds with a wide range of biological activity.
О. V. Kholodniak, Yu. V. Shubina, S. I. Kovalenko   +2 more
doaj   +1 more source

A Proline‐Integrated Donor–Acceptor Fluorophore: Water‐Vapor‐Responsive Mechanochromic Luminescence and Latent Fingerprint Visualization

Advanced Optical Materials, EarlyView.
A proline‐integrated donor–acceptor fluorophore enables multifunctional luminescence through rational molecular design. Water‐vapor‐responsive mechanochromic luminescence (MCL) with circularly polarized luminescence (CPL) switching and efficient visualization of latent fingerprints (LFPs) are realized from this single small organic molecule.
Hao Chen, Kazuki Kato, Yoshitane Imai, Suguru Ito   +3 more
wiley   +1 more source

Synthesis and Antibacterial Activities of Novel Imidazo[2,1-b]-1,3,4-thiadiazoles

Molecules, 2011
2-Amino-5-(2-aryl-2H-1,2,3-triazol-4-yl)-1,3,4-thiadiazoles 2-4 have been synthesized by the reaction of 2-aryl-2H-1,2,3-triazole-4-carboxylic acids 1 with thiosemicarbazide. Their reaction with phenacyl (p-substituted phenacyl) bromides led to formation
Kamal F. M. Atta, Omaima O.M. Farahat, Mohamed G. Marei, Alaa Z. A. Ahmed   +3 more
doaj   +1 more source

An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity

Advanced Science, EarlyView.
The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu   +9 more
wiley   +1 more source

Dual‐Module Near‐Infrared Fluorophores Discovery System via Knowledge Transfer

Advanced Science, EarlyView.
This study presents a dual‐module deep learning system for the design of near‐infrared (NIR) fluorophores. A large molecular library is generated and analyzed, leading to the suggestions of promising candidates. The effectiveness of the system is further validated through the synthesis, characterization, and in vivo imaging, demonstrating its potential
Yixin Zhu, Xia Ling, Xianhe Zhang, Chuanjiang Jian, Leilei Shi, Wentao Song, Xiaonan Wang, Bin Liu   +7 more
wiley   +1 more source

Synthesis of New 4-Vinyl-1,2,3-Thiadiazoles

, 2021
Simple and convenient methods for the synthesis of a range of new 1,2,3-thiadiazole derivatives, including ethyl esters, alcohols, and aldehydes, were developed.
Sinead T Keaveney (20250621), Marina A Tokareva (20250615), Tatiana V Glukhareva (20250618), Barbara A Messerle (20251236), Indrek Pernik (1353273)   +4 more
core  

Red Phosphorescence from Benzo[2,1,3]thiadiazoles at Room Temperature [PDF]

, 2016
We describe the red phosphorescence exhibited by a class of structurally simple benzo[2,1,3]thiadiazoles at room temperature. The photophysical properties of these molecules in deoxygenated cyclohexane, including their absorption spectra, steady-state ...
Graham T. Sazama (2029786), Graham T. Sazama, Tony Wu, Timothy M. Swager (1308438), Timothy M. Swager, Wu, Tony C, Gutierrez, Gregory D., Tony Wu (1525387), Baldo, Marc A, Gregory D. Gutierrez, Gregory D. Gutierrez (2796424), Swager, Timothy M, Marc A. Baldo (1484776), Sazama, Graham T., Marc A. Baldo   +14 more
core   +1 more source

Synthesis of Some Substituted 1,3,4-Oxadiazoles, Thiadiazoles and 1,2,4-Triazoles from Acid Chlorides [PDF]

مجلة التربية والعلم, 2013
The conversion of some acid chlorides to substituted 1,3,4-oxadiazole, 1,3,4-thiadiazoles and 1,2,4-triazoles is reported. Benzoyl chloride and 4- nitrobenzoyl chloride were treated with hydrazine hydrate in ethanol to give acid hydrazides (1,2), The ...
E. Q. Mahmood, O. Th. Ali, K. M. Daoud
doaj   +1 more source

Novel thiadiazole-thiazole hybrids: synthesis, molecular docking, and cytotoxicity evaluation against liver cancer cell lines

Journal of Taibah University for Science, 2022
One of the worst diseases, cancer claims millions of lives each year throughout the world, necessitating the creation of novel treatments. In this study, we designed a novel series of 1,3,4-thiadiazoles through the reaction of 2-(4-methyl-2-(2-(1 ...
Ghadah F. Aljohani, Tariq Z. Abolibda, Mohammad Alhilal, Jehan Y. Al-Humaidi, Suzan Alhilal, Hoda A. Ahmed, Sobhi M. Gomha   +6 more
doaj   +1 more source

I₂‑Mediated Oxidative C–N and N–S Bond Formation in Water: A Metal-Free Synthesis of 4,5-Disubstituted/N-Fused 3‑Amino-1,2,4-triazoles and 3‑Substituted 5‑Amino-1,2,4-thiadiazoles

, 2018
An environmentally benign and convenient strategy for the synthesis of 4,5-disubstituted/N-fused 3-amino-1,2,4-triazoles and 3-substituted 5-amino-1,2,4-thiadiazoles from isothiocyanates has been developed.
Nagesh Jatangi (3998549), Mangarao Nakka (546374), Nagaraju Tumula (3998543), Radha Krishna Palakodety (3998546)   +3 more
core   +1 more source