Results 61 to 70 of about 4,281 (225)
Smart Molecules, EarlyView.A smart design strategy for NIR‐II organic fluorophores is proposed by combining self‐driven Iterative evolution, deep Learning, and fragment‐based assembly. This work establishes a broadly applicable approach for molecular design, accelerating the discovery of NIR‐II fluorophores and extending to optoelectronic materials and therapeutic compounds ...
Yu Zhang +6 more
wiley +1 more source
Synthesis and antioxidant activity of styryl-1,3,4-thiadiazoles, pyrazolyl-1,3,4-thiadiazoles and isoxazolyl-1,3,4-thiadiazoles [PDF]
, 2017 325-333A new class of sulfonamido methyl linked styrylsulfonylmethyl-1,3,4-thiadiazoles, pyrazolyl and isoxazolyl 1,3,4-thiadiazoles have been synthesized from the synthetic intermediate 2-(arylaminosulfonylmethyl)-5- (Z-(styrylsulfonylmethyl))-1,3,4 ...
Padmavathi, V +5 more
core
Mass spectral studies of 3,5-Diamino-1,2,4-thiadiazoles
, 1977 The mass spectra and fragmentation mechanisms of some 5-alkyl(or aryl)amino-3-amino-, 5-amino-3- arylamino-, 3,5-bis(arylamino)-, 4- aryl-3-arylamino-5-imino-4,5-dihydro-, and 3-alkyl(or aryl)amino-4- aryl-5-arylimino-4,5-dihydro-1,2,4-thiadiazoles and ...
KN Rajasekharan, CP Joshua
core +1 more source
Journal of Animal Ecology, EarlyView.This study reveals how long‐term activation of jasmonic and salicylic acid signalling reshapes arthropod communities and plant fitness across seasons. By showing that induced defences generate contrasting outcomes and cascading trade‐offs across trophic levels, it challenges the assumption that induced resistance is uniformly beneficial in natural ...
Mônica F. Kersch‐Becker +6 more
wiley +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.2‐Pyrazoline‐5‐one derivative inhibits proliferation and migration and induces Bax‐mediated apoptosis in breast cancer cells. ABSTRACT The most common cancer in women worldwide is still breast cancer. Among its subtypes, luminal A and triple‐negative breast cancers present significant therapeutic challenges due to intrinsic drug resistance and absence ...
Sevgi Kocyigit Sevinc +3 more
wiley +1 more source
, 2020 A new synthetic approach to 1,2,4-thiadiazoles using tetra(n-butyl)ammonium peroxydisulfate via oxidative dimerization of thioamides is described. This new oxidative protocol is simple, highly efficient, and allows the practical synthesis of 1,2,4 ...
Yong Hae Kim (2676469) +2 more
core +1 more source
Recent progress on anti-cancer activity of thiadiazoles: A review
Results in ChemistryCancer, a life-threatening condition which has become one of the deadliest disease impacting human health. Conventional drugs have significant side effects and are prone to drug resistance, whereas innovative therapies are costly and place a large load ...
C.R. Santhosh +8 more
doaj +1 more source
Thiadiazole derivatives as anticancer agents [PDF]
Pharmacological Reports, 2020 AbstractIn spite of substantial progress made toward understanding cancer pathogenesis, this disease remains one of the leading causes of mortality. Thus, there is an urgent need to develop novel, more effective anticancer therapeutics. Thiadiazole ring is a versatile scaffold widely studied in medicinal chemistry.
openaire +2 more sources
Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source
Novel Nucleophilic 5-Substitution Route to 1,2,3-Thiadiazoles
, 2016 Novel Nucleophilic 5-Substitution Route to 1,2,3 ...
George N. Nikonov (3027468) +2 more
core +1 more source