Results 71 to 80 of about 4,593 (180)

Synthesis and Antibacterial Activities of Novel Imidazo[2,1-b]-1,3,4-thiadiazoles

Molecules, 2011
2-Amino-5-(2-aryl-2H-1,2,3-triazol-4-yl)-1,3,4-thiadiazoles 2-4 have been synthesized by the reaction of 2-aryl-2H-1,2,3-triazole-4-carboxylic acids 1 with thiosemicarbazide. Their reaction with phenacyl (p-substituted phenacyl) bromides led to formation
Kamal F. M. Atta, Omaima O.M. Farahat, Mohamed G. Marei, Alaa Z. A. Ahmed   +3 more
doaj   +1 more source

Synthesis Of 2-Benzamidomethyl-5-Substituted Amino-1,3,4-Thiadiazoles-2,5-Disubstituted 1,3,4-Oxadiazole and 4,5-Disubstituted 1,2,4-Triazole-3-Thiol [PDF]

مجلة التربية والعلم, 2012
In this paper the synthesis of some substituted 1,3,4-oxadiazoles , 1,3,4-thiadiazoles and 1,2,4-triazoles starting from amino acid and benzoyl chloride is reported.
K. M. Daoud, A. N. Ali, A. A. Ahmed
doaj   +1 more source

Reverse evolution of fluorine and side chains in bisisoindigo‐based copolymers enabling electron mobility exceeding 7 cm2·V−1·s−1

FlexMat, EarlyView.
Abstract We report the design and synthesis of a series of bisisoindigo‐based donor–acceptor (D–A) copolymers, P4F18, P4F10, P2F18, and P2F10. By reverse evolution of fluorine substitution and side‐chain structure, we effectively tuned the frontier molecular orbital energy levels, intermolecular interactions, molecular self‐assembly, and thus charge ...
Keli Shi, Chang Cui, Qianqian Zhao, Jianping Chen, Weifeng Zhang, Jiadi Chen, Qian Che, Yunchao Zhang, Youjia Li, Zhihui Chen, Liping Wang, Gui Yu   +11 more
wiley   +1 more source

Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors

FlexMat, EarlyView.
This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu, Yubing Hu, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Synthesis and antioxidant activity of styryl-1,3,4-thiadiazoles, pyrazolyl-1,3,4-thiadiazoles and isoxazolyl-1,3,4-thiadiazoles [PDF]

, 2017
325-333A new class of sulfonamido methyl linked styrylsulfonylmethyl-1,3,4-thiadiazoles, pyrazolyl and isoxazolyl 1,3,4-thiadiazoles have been synthesized from the synthetic intermediate 2-(arylaminosulfonylmethyl)-5- (Z-(styrylsulfonylmethyl))-1,3,4 ...
Padmavathi, V, Durgamma, S, Padmaja, A, Yamini, G, Syamaiah, K, Reddy, G Mallikarjuna   +5 more
core  

Recent progress on anti-cancer activity of thiadiazoles: A review

Results in Chemistry
Cancer, a life-threatening condition which has become one of the deadliest disease impacting human health. Conventional drugs have significant side effects and are prone to drug resistance, whereas innovative therapies are costly and place a large load ...
C.R. Santhosh, Sampath Chinnam, Nagaraju Kottam, S Amreen, Guddekoppa S. Ananthnag, G.M. Madhu, Samata Gadde, Viola Tressa Fernandes, Haritha Arnipalli   +8 more
doaj   +1 more source

Band Engineering of Benzothiadiazole‐Derived Metal‐Organic Frameworks for Photocatalytic Organic Transformations

National Materials, EarlyView.
BTID‐functionalized metal‐organic frameworks provide a modular platform for tailoring photocatalytic electronic structures through acceptor‐linker engineering. By correlating band alignment, charge‐transfer characteristics, and reactive oxygen species generation, this review highlights design principles that enable efficient visible‐light‐driven ...
Xin Li, Long‐Shuang Chen, Meng‐Hao Li, Ying‐Wei Yang   +3 more
wiley   +1 more source

FXF‐OMe Is a Stable Tripeptide Motif for Ultra‐Short Peptide Coacervates That Establishes Structure‐Property‐Function Relationships

Small, EarlyView.
Ultra‐short peptides with a minimal sticker‐spacer structure undergo liquid‐liquid phase separation, resulting in condensates with microenvironments controlled by the hydrophobicity of the spacers. The condensates provide an easily tunable and exceptionally stable scaffold for photocatalytic microreactors in aqueous media, where catalysis efficiency is
Samuel Hamroff, Lucas Caire da Silva
wiley   +1 more source