Results 21 to 30 of about 4,593 (180)

Design, synthesis, and biological evaluation of thiazole/thiadiazole carboxamide scaffold-based derivatives as potential c-Met kinase inhibitors for cancer treatment

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
As part of our continuous efforts to discover novel c-Met inhibitors as antitumor agents, four series of thiazole/thiadiazole carboxamide-derived analogues were designed, synthesised, and evaluated for the in vitro activity against c-Met and four human ...
Xiang Nan, Qiu-Xu Wang, Shao-Jun Xing, Zhi-Gang Liang   +3 more
doaj   +1 more source

Synthesis, Molecular Docking Screening and Anti-Proliferative Potency Evaluation of Some New Imidazo[2,1-b]Thiazole Linked Thiadiazole Conjugates

Molecules, 2020
Background: Imidazo[2,1-b]thiazole scaffolds were reported to possess various pharmaceutical activities. Results: The novel compound named methyl-2-(1-(3-methyl-6-(p-tolyl)imidazo[2,1-b]thiazol-2-yl)ethylidene)hydrazine-1-carbodithioate 3 acted as a ...
Huda R. M. Rashdan, Aboubakr H. Abdelmonsef, Ihsan A. Shehadi, Sobhi M. Gomha, Abdel Mohsen M. Soliman, Huda K. Mahmoud   +5 more
doaj   +1 more source

On the Development of Selective Chelators for Cadmium: Synthesis, Structure and Chelating Properties of 3-((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)benzo[d]isothiazole 1,1-dioxide, a Novel Thiadiazolyl Saccharinate

Molecules, 2021
Aquatic contamination by heavy metals is a major concern for the serious negative consequences it has for plants, animals, and humans. Among the most toxic metals, Cd(II) stands out since selective and truly efficient methodologies for its removal are ...
Joana F. Leal, Bruno Guerreiro, Patrícia S. M. Amado, André L. Fernandes, Luísa Barreira, José A. Paixão, Maria L. S. Cristiano   +6 more
doaj   +1 more source

A Novel Approach to the Synthesis of 1,3,4-Thiadiazole-2-amine Derivatives

Molecules, 2021
The main purpose of the study was the development of a new method for synthesis of 1,3,4-thiadiazol-2-amine derivatives in a one-pot manner using the reaction between a thiosemicarbazide and carboxylic acid without toxic additives such as POCl3 or SOCl2.
Tatiana S. Kokovina, Svyatoslav Y. Gadomsky, Alexei A. Terentiev, Nataliya A. Sanina   +3 more
doaj   +1 more source

Synthesis and Biological evalution of some substituted 2-dibenzyl amino 1,3,4-oxadiazoles , thiadiazoles and 1,2,4-triazoles [PDF]

مجلة التربية والعلم, 2013
In this paper the synthesis of some substituted 2-dibenzyl 1,3,4-oxadiazole, thiadiazole and 1,2,4-triazoles derived from dibenzyl amine is reported scheme-1.
Khalid Daoud, Shaima Ismmaeel
doaj   +1 more source

Development of Rh(I)-catalyzed denitrogenative transformations of 1,2,3-thiadiazoles

, 2023
Presented herein are a series of studies designed to increase the fundamental understanding, and expand the application in heterocyclic synthesis, of the Rh(I)-catalyzed denitrogenative transformations of 1,2,3-thiadiazoles − a new class of reactions ...
Marina A. Tokareva (17255824)
core   +1 more source

Design and Synthesis of New Benzo[d]oxazole-Based Derivatives and Their Neuroprotective Effects on β-Amyloid-Induced PC12 Cells

Molecules, 2020
A series of novel synthetic substituted benzo[d]oxazole-based derivatives (5a–5v) exerted neuroprotective effects on β-amyloid (Aβ)-induced PC12 cells as a potential approach for the treatment of Alzheimer’s disease (AD).
Zheng Liu, Ming Bian, Qian-Qian Ma, Zhuo Zhang, Huan-Huan Du, Cheng-Xi Wei   +5 more
doaj   +1 more source

Differentiation between Isomeric 4,5-Functionalized 1,2,3-Thiadiazoles and 1,2,3-Triazoles by ESI-HRMS and IR Ion Spectroscopy

Molecules, 2023
A large variety of 1,2,3-thiadiazoles and 1,2,3-triazoles are used extensively in modern pure and applied organic chemistry as important structural blocks of numerous valuable products.
Dmitrii M. Mazur, Elettra L. Piacentino, Giel Berden, Jos. Oomens, Victor Ryzhov, Vasiliy A. Bakulev, Albert T. Lebedev   +6 more
doaj   +1 more source

3-Phenoxymethyl-6-phenyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole

IUCrData, 2016
In the title compound, C16H12N4OS, the bicyclic triazolothiadiazole core is approximately planar, with an r.m.s. deviation of 0.018 Å. The phenyl rings are inclined to its mean plane by 7.66 (7) and 71.79 (7)°.
Shaaban K. Mohamed, Joel T. Mague, Mehmet Akkurt, Etify A. Bakhite, Mustafa R. Albayati   +4 more
doaj   +1 more source

Synthesis of 2- alkyl/phenyl -5-Substituted 1,3,4- Thiadiazoles [PDF]

مجلة التربية والعلم, 2014
In this paper the synthesis of some 2-alkyl phenyl 5-substituted 1,3,4-thiadiazole is reported, Benzonitrile and Acetonitrile were treated with thiosemicarbazide in presence of trifluroacetic acid to give 2-alkyl/ aryl -5- amino- 1,3,4- thiadiazoles (1,2)
Khalid Daoud, Shaima Ismaeel, Yassir Mohamad   +2 more
doaj   +1 more source