Results 71 to 80 of about 27,190 (294)

Synthesis and Antibacterial Activities of Novel Imidazo[2,1-b]-1,3,4-thiadiazoles

Molecules, 2011
2-Amino-5-(2-aryl-2H-1,2,3-triazol-4-yl)-1,3,4-thiadiazoles 2-4 have been synthesized by the reaction of 2-aryl-2H-1,2,3-triazole-4-carboxylic acids 1 with thiosemicarbazide. Their reaction with phenacyl (p-substituted phenacyl) bromides led to formation
Kamal F. M. Atta, Omaima O.M. Farahat, Mohamed G. Marei, Alaa Z. A. Ahmed   +3 more
doaj   +1 more source

Synthesis and properties of nitrogen-containing 1,2,3-thiadiazoles [PDF]

, 2013
Одно из наиболее перспективных направлений в развитии химии гетероциклических соединений представляет собой синтез и изучение химических свойств и биологической активности моно- и бициклических систем на основе 1,2,3-тиадиазолов.
Kalinina, T. A., Калинина, Т. А.   +1 more
core  

Future Prospects in the Treatment of Parasitic Diseases: 2-Amino-1,3,4-Thiadiazoles in Leishmaniasis

Molecules, 2019
Neglected tropical diseases affect the lives of a billion people worldwide. Among them, the parasitic infections caused by protozoan parasites of the Trypanosomatidae family have a huge impact on human health. Leishmaniasis, caused by Leishmania spp., is
G. Serban
semanticscholar   +1 more source

Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain [PDF]

, 2016
The antiapoptotic protein BCL 2 is overexpressed in several cancers and contributes to prolonged cell survival and chemoresistance, lending itself as an excellent target for cancer therapy.
Anderson, Arkin, Beauchard, Campos, Case, Chiruvella, Cho, Cotter, Dai, Delft, el-Sherbeny, Fedorov, Ferri, Gross, Gutierrez-Puente, Hanada, Iyer, Karki, Kavitha, Kavitha, Kavitha, Khaw, Kirkin, Kitada, Kolluri, Konopleva, Kumar, Lin, Lotem, Marschitz, Mologni, Moorthy, Morris, Nambiar, Nedelkina, Niesen, Oakes, Pan, Pentimalli, Real, Reed, Rosen, Shahabuddin, Shangary, Sharma, Souers, Srivastava, Srivastava, Trott, Vaillant, Vedadi, Vogler, Wang, Wang, Wang, Willis, Wlodkowic, Zhai   +57 more
core   +1 more source

Rational Design of Donor‐Acceptor Oligomers for Enhanced Charge Separation

Advanced Physics Research, EarlyView.
How can molecular symmetry be broken to maximize photoinduced charge separation? Through first‐principles analysis of 22 DTP‐based donor‐acceptor ternary oligomers, this work establishes that combining architectural asymmetry with site‐selective acceptor fluorination creates an ideal electrostatic landscape for frontier orbital segregation.
Jannik Theile, Michele Guerrini, Surender Kumar, Caterina Cocchi   +3 more
wiley   +1 more source

Synthesis, Spectroscopy and Crystal Structure of 2‐Ethyl‐6‐(4‐nitrophenyl)imidazo[2,1‐b] [1,3,4]thiadiazole‐5‐carbaldehyde. [PDF]

, 2006
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals.
Girija, C.R., Hegde, V.S., Khazi, I.M., Kolavi, G.D., Noor Shahina Begum, ., Vasundhara, D.E.   +5 more
core   +1 more source

Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity

BMC Cancer, 2017
BackgroundExpression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and poor prognosis of many cancers which makes it an attractive drug target in cancer ...
C. Baburajeev, C. D. Mohan, S. Rangappa, Daniel J. Mason, Julian E. Fuchs, A. Bender, Uri Barash, I. Vlodavsky, Basappa, K. Rangappa   +9 more
semanticscholar   +1 more source

The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches.
Ahmet Esat Göner, Hatice Esra Duran
wiley   +1 more source

Metal‐Free Covalent Organic Frameworks for Photocatalytic CO2 Reduction

ChemistryEurope, EarlyView.
This review presents an environmentally sustainable strategy to address the critical issue of escalating atmospheric CO2 levels. It explores the application of metal‐free covalent organic frameworks in a photocatalytic approach, offering a green and efficient strategy for carbon dioxide reduction and contributing to climate change mitigation.
Supriti Dutta, Akhtar Alam, Pekham Chakrabortty, Pradip Pachfule   +3 more
wiley   +1 more source

Synthesis and Screening of Substituted Thiadiazoles Against Gleophyllum Straitum

E-Journal of Chemistry, 2004
Cyclocondensation of a series of substituted phenoxy methylene carboxylic acids with thiosemoicarbazides afforded 2-Amino-5-Aryloxy Methylene –1,3,4 Thiadiazoles (Ia-Ie).
M. G. H. Zaidi, Seema Zaidi, I. P. Pandey   +2 more
doaj   +1 more source