Results 91 to 100 of about 11,021 (223)

Drainage of Pleural Effusion in the Intensive Care Unit (DOPE‐ICU) Feasibility Trial—Protocol and Statistical Analysis Plan

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 5, May 2026.
ABSTRACT Pleural effusions are common in adult intensive care unit (ICU) patients with respiratory failure. Ultrasonography‐guided therapeutic pleural drainage is widely used and associated with improved oxygenation and ventilatory parameters, but no randomised clinical trial data exist.
Marie Schjødt Worm, Morten Hylander Møller, Niels Henrik Bruun, Anne Craveiro Brøchner, Morten Heiberg Bestle, Bodil Steen Rasmussen, Olav Lilleholt Schjørring   +6 more
wiley   +1 more source

Efficacy of chlorthalidone and hydrochlorothiazide in combination with amiloride in multiple doses on blood pressure in patients with primary hypertension: a protocol for a factorial randomized controlled trial

Trials, 2019
Background Thiazide diuretics have demonstrated favorable blood pressure lowering efficacy, but the equivalent doses of their more common agents, chlorthalidone and hydrochlorothiazide, are still unclear.
Vítor Magnus Martins, Lucas Helal, Filipe Ferrari, Leonardo Grabinski Bottino, Sandra Costa Fuchs, Flávio Danni Fuchs   +5 more
doaj   +1 more source

Low‐Salt Diet Induces Claudin‐3 Expression and Drives Adaptive Changes in Collecting Duct of Claudin‐3‐Deficient Mice

Acta Physiologica, Volume 242, Issue 5, May 2026.
ABSTRACT Aim Renal sodium reabsorption occurs through both transcellular and paracellular pathways. Tight junction proteins play a key role in mediating paracellular transport. The collecting duct is critical for the fine tuning of sodium balance and is highly responsive to changes in dietary salt intake.
Ali Sassi, Alexandra Chassot, Sara Jellali, Nicolas Liaudet, Ana Polat, Felix Baier, Deborah Stroka, Mikio Furuse, Eric Feraille   +8 more
wiley   +1 more source

Minimally sufficient numbers of measurements for validation of 24-hour blood pressure monitoring in chronic kidney disease [PDF]

, 2018
Ambulatory blood pressure monitoring (ABPM) remains a reference standard, but the minimal number of ABPM readings required to diagnose hypertension has not been empirically validated. Among 360 patients with chronic kidney disease and 38 healthy controls,
Agarwal, Rajiv, Tu, Wanzhu
core   +1 more source

Effect of Diuretics on Cutaneous Squamous Cell Carcinoma: Clinical and Translational Evidence

International Journal of Dermatology, EarlyView.
Kevin Sheng‐Kai Ma, Stefano Sol, Fabiana Boncimino, Serena Yun‐Chen Tsai, Bethany J. Brumbaugh, Anna Mandinova, Steven T. Chen   +6 more
wiley   +1 more source

Sustained glucagon‐like peptide‐1 receptor agonist treatment improves glycemic control and reduces all‐cause mortality compared to dipeptidyl peptidase‐4 inhibitors: A real‐world target trial emulation in type 2 diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3974-3984, May 2026.
Abstract Background Glucagon‐like peptide 1 receptor agonists (GLP‐1 RAs) improve glycemic outcomes in people with type 2 diabetes, but their generalizability to routine clinical practice remains uncertain. Aim To evaluate the real‐world effectiveness of sustained GLP‐1 RA use on haemoglobin A1c (HbA1c) over 1 to 4.5 years, using dipeptidyl peptidase 4
Kathrine Kold Sørensen, Puriya Daniel Würtz Yazdanfard, Bochra Zareini, Hannah Karin Wood‐Kurland, Ulrik Pedersen‐Bjergaard, Mikkel Porsborg Andersen, Jens Michelsen, Henrik Imberg, Marcus Lind, Sara Hallström, Stefanie Lanzinger, Anders Munch, Johan Sebastian Ohlendorff, Thomas Alexander Gerds, Christian Torp‐Pedersen, The REDDIE Consortium   +15 more
wiley   +1 more source

Thiazide Diuretics and the Incidence of Osteoporotic Fracture: A Systematic Review and Meta-Analysis of Cohort Studies

Frontiers in Pharmacology, 2019
Background: Thiazide diuretics may improve bone mineral density. However, results are inconsistent for studies evaluating the association between thiazides and risk of osteoporotic fracture.
Jun Wang, Ke Su, Weihua Sang, Longjie Li, Shiyun Ma   +4 more
doaj   +1 more source

Comparison of SGLT2 Inhibitors for New‐Onset Proteinuria Risk in Patients With Type 2 Diabetes and Preserved Kidney Function

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4314-4325, May 2026.
ABSTRACT Aims To compare the effects of individual SGLT2 inhibitors on preventing new‐onset proteinuria in patients with type 2 diabetes and preserved kidney function. Materials and Methods A target trial emulation was performed using commercially available databases, including health checkups and claims data, between April 1, 2014 and March 31, 2023 ...
Hiroki Nobayashi, Michihiro Satoh, Takuo Hirose, Shingo Nakayama, Yutaro Iwabe, Hideaki Hashimoto, Takahisa Murakami, Kouji Okada, Takefumi Mori, Hirohito Metoki   +9 more
wiley   +1 more source

Rational Prescribing in Primary care (RaPP): process evaluation of an intervention to improve prescribing of antihypertensive and cholesterol-lowering drugs

Implementation Science, 2006
Background A randomised trial of a multifaceted intervention for improving adherence to clinical practice guidelines for the pharmacological management of hypertension and hypercholesterolemia increased prescribing of thiazides, butdetected no impact ...
Oxman Andrew D, Håvelsrud Kari, Fretheim Atle   +2 more
doaj   +1 more source

Neurohormonal consequences of diuretics in different cardiovascular syndromes [PDF]

, 2017
Diuretics have long been used to lower blood pressure in hypertensive patients or to control body fluid and electrolyte homeostasis in diseases such as congestive heart failure, chronic renal failure or cirrhosis.
Brunner, H. R., Burnier, M.
core