Results 91 to 100 of about 7,524 (233)

Clinical Report and Genetic Analysis of a Patient With Congenital Hyperinsulinism Hyperammonemia Caused by a Novel Missense Mutation in the Structural Domain of the Isoform of the GLUD1 Gene

Clinical Case Reports, Volume 14, Issue 6, June 2026.
This patient was admitted to the hospital 43 h after birth with convulsions and hypoglycemia, presenting as recurrent refractory hypoglycemia that was difficult to control with conventional medication. Whole exome sequencing detected the GLUD1 (NM_005271.3:c.1495G>T, p.Gly499Cys) variant, which was a de novo variant in the patient and was not detected ...
Tingyu Li, Tianyi Liu, Lujuan Li, Yang Liu, Qi Zhang, Xian Cheng, Zhong Li   +6 more
wiley   +1 more source

Thiazide diabetes [PDF]

Postgraduate Medical Journal, 1966
E L, Harris, R O, Hardwick
openaire   +2 more sources

Thiazide Diuretics in Hypertension

Clinical and Experimental Hypertension, 1999
Thiazide diuretics have antihypertensive efficacy equivalent to that of the other major classes of antihypertensive drug, and are at least as well tolerated as judged by discontinuation rates and measures of quality of life. They are effective when given once daily, require no dose titration, have few contraindications, and have additive effects when ...
openaire   +2 more sources

Prognostic effect of the combined use of thiazides and loop diuretics at discharge following a hospitalization for acute heart failure

Aims There is limited information regarding the clinical impact of the concurrent use of thiazides and loop diuretics (LD) after an episode of acute heart failure (AHF) hospitalization.
Miñana, Gema, Montiel, Jorge, de la Espriella, Rafael, Núñez Aragon, Raquel, Fernández Cisnal, Agustín, Trullàs, Joan Carles, Lorenzo Hernández, Miguel, Miró, Òscar, Núñez-Vicent Bodí, Gonzalo, López Sáez, José Juan Bosco, Núñez, Julio, Sanchis, Juan, Valero, Ernesto, Bayés‑Genis, Antoni, Gasull, Andrea   +14 more
core   +1 more source

Optimal age of commencing and discontinuing thiazide therapy to protect against fractures

, 2016
A study of national Danish patient data with regard to thiazide diuretics vs. non-treatment. We find that after age 83 years, thiazides increase the 10-year risk of major fractures.
Kruse, C, Vestergaard, Peter, Eiken, P, Vestergaard, P; id_orcid   +3 more
core   +1 more source

Diuretic Intensity Score and Mortality in Hospitalized Heart Failure Patients: A Multicenter Propensity‐Matched Analysis

Clinical Cardiology, Volume 49, Issue 6, June 2026.
In two independent cohorts of 17 826 hospitalized heart failure patients (MIMIC‐IV and a Chinese database), a higher Diuretic Intensity Score was associated with lower 28‐ and 90‐day all‐cause mortality. These findings are hypothesis‐generating and warrant validation in prospective randomized trials.
Jianwei Zhou
wiley   +1 more source

Thiazide-induced hyponatremia

Best Practice & Research Clinical Endocrinology & Metabolism
Thiazide diuretics are widely used antihypertensive agents, but their use can be complicated by thiazide-induced hyponatremia (TIH), a more common adverse effect than previously recognized. TIH may present acutely or chronically, with neurological symptoms varying by onset.
Beckmann, Sebastian B., Rudolphi, Crissy F., Silva, Pedro H.Imenez, Fenton, Robert A.; id_orcid 0000-0003-1623-199X, Hoorn, Ewout J.   +4 more
openaire   +2 more sources

EFFECT OF THIAZIDES ON METACORTICOID HYPERTENSION AND ON THYROID ACTIVITY OF RATS

, 1965
Chronic oral administration of either chlorothiazide (3.8 g/kg food) or hydrochlorothiazide (0.6 g/kg food) provides significant protection against metacorticoid hypertension induced by desoxycorticosterone trimethylacetate (post-DTMA hypertension) in ...
Melvin J. Fregly, Joseph F. Gennaro Jr.
core   +1 more source

Serum Uric Acid as a Sex‐Dependent Risk Marker of Post‐Stroke Epilepsy After Acute Ischemic Stroke: Complementary Mendelian Randomization and Cohort Analyses

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
In 21,459 acute ischemic stroke patients, Mendelian randomization found no shared genetic causal link between serum uric acid and epilepsy. Elevated admission uric acid was a robust risk marker for post‐stroke epilepsy in women but not men, with the apparent male protective association sensitive to stratification method.
Yan Cheng, Ji Li, Yunzhou Yang
wiley   +1 more source

Rational Prescribing in Primary care (RaPP): process evaluation of an intervention to improve prescribing of antihypertensive and cholesterol-lowering drugs

Implementation Science, 2006
Background A randomised trial of a multifaceted intervention for improving adherence to clinical practice guidelines for the pharmacological management of hypertension and hypercholesterolemia increased prescribing of thiazides, butdetected no impact ...
Oxman Andrew D, Håvelsrud Kari, Fretheim Atle   +2 more
doaj   +1 more source