Results 61 to 70 of about 7,524 (233)

A quasi-experimental test of an intervention to increase the use of thiazide-based treatment regimens for people with hypertension

Implementation Science, 2007
Background Despite recent high-quality evidence for their cost-effectiveness, thiazides are underused for controlling hypertension. The goal of this study was to design and test a practice-based intervention aimed at increasing the use of thiazide-based ...
Beyth Rebecca J, Stanberry Elizabeth, Walder Annette, Johnson Michael L, Khan Myrna M, Ashton Carol M, Collins Tracie C, Gordon Howard S, Haidet Paul, Kimmel Barbara, Kolpakchi Anna, Lu Lee B, Naik Aanand D, Petersen Laura A, Singh Hardeep, Wray Nelda P   +15 more
doaj   +1 more source

Trends in antihypertensive drugs in the elderly: the decline of thiazides

, 2001
The last decade has seen the publication of different editions of guidelines for the pharmacological treatment of hypertension that were based on the results of large, randomised trials.
G. Onder, G. Gambassi, R. Bernabei, C. Pedone, Landi, Francesco Luigi, Pedone, Claudio, M. Cesari, Gambassi, Giovanni, F. Landi, Carbonin, Pierugo, Bernabei, Roberto, Onder, Graziano, Cesari, Matteo, P. U. Carbonin   +13 more
core   +1 more source

Genetic Insights Into AVP Deficiency: Identification of a Novel AVP Variant and Compilation of a Curated Catalogue of Pathogenic Variants

Clinical Genetics, EarlyView.
We identified a novel pathogenic AVP variant in two Danish families with autosomal dominant inheritance of symptoms of AVP deficiency. In addition, we compiled a catalogue of additionally 109 AVP variants that cause AVP deficiency and demonstrated the advantage of combining expert‐assisted curation, literature search, and online repositories to ensure ...
Jennifa Joseph, Esben Søndergaard, Sine Knorr, Jane Hagelskjær Knudsen, Søren Rittig, Jane Hvarregaard Christensen   +5 more
wiley   +1 more source

Selective effect of thiazides on the human osteoblast-like cell line MG-63

, 1996
Selective effect of thiazides on the human osteoblast-like cell line MG-63. Thiazide diuretics have been shown to decrease bone-loss rate and to improve bone mineral density in patients using this medication.
Lajeunesse, Daniel, Aubin, R., Ménard, P.   +2 more
core   +1 more source

A retrospective case-control study evaluating thiazide-induced hyponatraemia-related hospitalisation among older Singaporeans

Proceedings of Singapore Healthcare, 2017
Introduction: Thiazide diuretics are recommended as first-line therapy for hypertension in older adults. However, thiazides are also associated with hyponatraemia-related hospitalisations in older patients.
Jishana Farhad Abdul Naseer, Li Li Chen, Huey Sywu Gui, Kheng Yong Ong, Mcvin Hua Heng Cheen, Kaysar Mamun   +5 more
doaj   +1 more source

Cost‐Effectiveness of NT‐proBNP–Guided Cardiovascular Screening in Chinese Adults With Type 2 Diabetes: Real‐World Evidence From the Hong Kong Diabetes Biobank

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Heart failure (HF) is among the most costly and prevalent complications of type 2 diabetes (T2D), with annual incremental healthcare costs reaching US$12800 in Hong Kong. We evaluated the cost‐effectiveness of NT‐proBNP‐guided cardiovascular risk stratification to guide cardioprotective treatment. Materials and Methods We developed a four‐
Abby Q. Y. Li, Benjamin Yarnoff, Claudia H. T. Tam, Juliana C. N. Chan, Ronald C. W. Ma, Juliana N. M. Lui, Hong Kong Diabetes Biobank Study Group   +6 more
wiley   +1 more source

Empagliflozin Versus Dapagliflozin and Urogenital Adverse Events in Type 2 Diabetes: A Target Trial Emulation

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Urogenital adverse events are common with sodium‐glucose co‐transporter 2 inhibitors (SGLT2i) and may influence treatment decisions. Variations in SGLT2i selectivity, potency and effects on renal glucose excretion could lead to differences in safety profiles. We compared the risks of urinary tract infection (UTI), genital tract infection (
Christine Ljungberg, Kasper Bonnesen, Morten Schmidt, Christina Vandenbroucke‐Grauls, Michael Dalager‐Pedersen, Henrik Toft Sørensen, Mette Nørgaard, Reimar Wernich Thomsen   +7 more
wiley   +1 more source

Inflammatory Pathways of Sulfonamide Diuretics: Insights into SLC12A Cl– Symporters and Additional Targets

Cellular Physiology and Biochemistry
Thiazide, thiazide-like, and loop diuretics are primarily known for inhibiting members of the SLC12A family of Cl– transporters, which include the Na+Cl– cotransporter (NCC), Na+K+2Cl– cotransporters (NKCC1 and NKCC2) and K+Cl– symporters (KCC1-4). While
Mauricio Di Fulvio
doaj   +1 more source

Effect of sodium–glucose cotransporter 2 inhibitors on heart failure readmission in older patients with diabetes: A Japanese claims‐based cohort study

Journal of Diabetes Investigation, EarlyView.
SGLT2 inhibitor use at discharge was associated with a reduced risk of heart failure readmission in elderly patients with diabetes, with no significant differences among individual agents. ABSTRACT Aims To evaluate the effect of sodium–glucose cotransporter 2 inhibitor (SGLT2i) administration at hospital discharge on heart failure (HF) readmission ...
Kazuya Hiura, Hirotaka Masuda, Masayuki Sakunami, Miki Yamashita   +3 more
wiley   +1 more source

Comparative effectiveness of antihypertensive monotherapies in primary prevention of cardiovascular events—a real-world longitudinal inception cohort study

Frontiers in Pharmacology
IntroductionAntihypertensive drugs are used preventatively to lower the risk of cardiovascular disease events. Comparative effectiveness studies on angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), beta-blockers ...
Xuechun Li, Maarten J. Bijlsma, Maarten J. Bijlsma, Stijn de Vos, Jens H. J. Bos, Sumaira Mubarik, Catharina C. M. Schuiling-Veninga, Eelko Hak   +7 more
doaj   +1 more source