Results 101 to 110 of about 36,963 (239)

Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Isatin-Thiazole Derivatives as α-Glucosidase Inhibitors

Molecules, 2017
A series of novel isatin-thiazole derivatives were synthesized and screened for their in vitro α-glucosidase inhibitory activity. These compounds displayed a varying degree of α-glucosidase inhibitory activity with IC50 ranging from 5.36 ± 0.13 to 35.76 ±
Zhenzhen Xie, Guangcheng Wang, Jing Wang, Ming Chen, Yaping Peng, Luyao Li, Bing Deng, Shan Chen, Wenbiao Li   +8 more
doaj   +1 more source

Metal chelates derived from 2,4-Bis-(2-pyridyl)thiazole and 2-(2-pyridylamino)-4-(2-pyridyl)thiazole

, 1964
The bases 2,4-bis-(2-pyridyl)thiazole and 2-(2-pyridylamino)-4-(2-pyridyl)thiazole have been prepared by an adaptation of the Hantzsch thiazole synthesis.
HA Goodwin
core   +1 more source

Design, synthesis and activity evaluation of tetrahydroisoquinoline‐based programmed cell death ligand 1 inhibitors

Smart Molecules, EarlyView.
Based on a 3D‐quantitative structure‐activity relationship pharmacophore model, structural optimization of Y6 yielded Y7f. Mechanistic studies revealed that Y7f acted as a programmed death receptor 1/programmed cell death ligand 1 (PD‐L1) interaction inhibitor by inducing PD‐L1 dimerization. Y7f restored T‐cell function.
Menglin Yu, Sen Cai, Yanyan Pan, Heshuang Wang, Fengwu Zhang, Aiyu Ma, Shixuan Lv, Xiuhan Guo, Shisheng Wang, Qiling Song, Chunyan Ma, Shuai Wang, Li Zhang, Jian Wang, Qingwei Meng, Yueqing Li   +15 more
wiley   +1 more source

2-[5-(4-Fluorophenyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)thiazole

IUCrData, 2019
The title compound, C28H23FN6S, comprises phenyl (A), triazolyl (B), thiazolyl (C), pyrazoyl (D), tolyl (E) and fluorophenyl (F) rings, with twist angles between neighbouring rings pairs A/B, B/C, C/D, D/E and D/F of 64.6 (1), 11.7 (2), 23.5 (2), 8.2 (2)
Gamal A. El-Hiti, Bakr F. Abdel-Wahab, Emad Yousif, Mohammad Hayal Alotaibi, Amany S. Hegazy, Benson M. Kariuki   +5 more
doaj   +1 more source

Synthesis of Oligonucleotides Containing Thiazole and Thiazole N-Oxide Nucleobases

, 2016
The thiazole C-nucleoside analogue was synthesized by the Hantzsch cyclization method to form the thiazole ring and was then converted to the thiazole N-oxide C-nucleoside analogue by peracid oxidation of the heterocycle nitrogen.
Tod J. Miller (3030417), Hannah D. Farquar (3064794), Camille E. Tallini (3064797), Robert P. Hammer (1478716), Arsham Sheybani (3064800), Andrea S. Saurage (3064803), Frank R. Fronczek (568703)   +6 more
core   +1 more source

Sulfur‐ and Selenium‐Decorated Coumarins: Synthetic Strategies Involving Cyclization and Late‐Stage Functionalization

The Chemical Record, EarlyView.
Two decades of synthetic strategies for sulfur‐, selenium‐decorated coumarins are critically surveyed through 44 literature reports, with particular emphasis on derivatives functionalized at the C‐3 and C‐4 positions. This review reports the direct construction of the coumarin framework through cyclization processes and late‐stage functionalization of ...
Bruna R. Schneider, Laura D. de Avila, Mauricio C. D. F. Xavier, Alex F. C. Flores, Liane K. Soares, Gabriel P. da Costa, Angelita M. Barcellos   +6 more
wiley   +1 more source

Two-Dimensional Covalent Organic Frameworks with Carbazole-Embedded Frameworks Facilitate Photocatalytic and Electrocatalytic Processes

Molecules
Catalytic technologies are pivotal in enhancing energy efficiency, promoting clean energy production, and reducing energy consumption in the chemical industry. The pursuit of novel catalysts for renewable energy is a long-term goal for researchers.
Yuchen Xiao, Shanyue Wei, Xiaowei Wu, Canzhong Lu   +3 more
doaj   +1 more source

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

Journal of Applied Toxicology, Volume 46, Issue 12, Page 4396-4408, December 2026.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto, Daniel Vitor de Souza, Gabriel Carvalhal de Aguiar, Ana Claudia Muniz Renno, Patricia Ramos Cury, Jean Nunes dos Santos, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

Molecular analysis of vibrational and structural characteristics in bi-thiazole derivatives

Discover Chemistry
Thiazole and bi-thiazole-based compounds’ vital role in broad-spectrum biological activities attracts immeasurable research interest to investigate their molecular characteristics.
Shweta Dagar, Vishwas Chaudhri, Sidhant Yadav, Rashmi Pundeer, Anurag Prakash Sunda   +4 more
doaj   +1 more source

Thermodynamic Functions of Thiazole and iso-Thiazole

Croatica Chemica Acta, 1968
Some thermodynamic functions (the enthalpy and free energy functi ons, entropy and heat capacity) of thiazole and iso-thiazole have been calculated (300-1000° K), using the harmonic-oscillator, rigid-rotor approximation. The reported assignments for the two molecules were us ed, as were the published values for the moments of inertia of thiazole ...
openaire   +2 more sources