Results 81 to 90 of about 46,327 (259)

Synthesis and biological activity evaluation of new functionally substituted 5-arylidene-2,4-dioxotetrahydro-1,3-thiazoles [PDF]

Journal of the Serbian Chemical Society, 2006
New functionally substituted 5-arylidene-2,4-dioxotetrahydro-1,3-thiazole-3-carboxylic acid cholesteryl esters were synthesized from 2,4-dioxotetrahydro-1,3-thiazole and evaluated for their in vitro cytotoxicity against several human tumor cell lines and
MIROSLAV PERGAL, MILICA RANCIC, KATARINA POPOV-PERGAL, GORDANA BOGDANOVIC, VESNA KOJIC, DEJAN DJOKOVIC   +5 more
doaj  

Some Studies in Sulfadiazine Incorporating Pyridine, Pyrimidine, Oxadiazole, and Azo Moieties Endowed with Pharmaceutical Potency

Acta Chimica Slovenica, 2020
A set of substituted sulfadiazine compounds was prepared as cytotoxic and antitumor agents by using 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide (1) as the starting material.
Sherihan El-Hadidy, Sraa Abu-Melha
doaj   +1 more source

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

Comprehensive review on coumarin–thiazole hybrids: Synthesis, characterization, in silico studies, and biological perspectives

Bulletin of Pharmaceutical Sciences. Assiut University
The hybrid molecules with various pharmacological actions are believed to emerge on the combination of coumarin and thiazole scaffolds. The bioactive scaffolds of coumarin and thiazole comprise such derivatives and have a broad spectrum of biological ...
Noor Abd Alhassan, Leaqaa Abd Ridha
doaj   +1 more source

6′-(3-Bromophenyl)-7′-nitro-1′,6′,7′,7a'-tetrahydro-3′H-spiro[indeno[1,2-b]quinoxaline-11,5′-pyrrolo[1,2-c]thiazole]

IUCrData, 2018
The title compound, C26H19BrN4O2S, crystallizes in a monoclinic C-centred lattice with eight molecules in the unit cell. The five-membered thiazole and pyrrolidine rings adopt envelope conformations and the bromophenyl and indenoquinoxaline planes are ...
C. Muthuselvi, M. Muthu, S. Athimoolam, B. Ravikumar, S. Pandiarajan, R. V. Krishnakumar   +5 more
doaj   +1 more source

Synthesis of DNA Building Blocks With Aminonaphthalimides and Cyanovinylenes as Uncharged Fluorophores: Fluorescent Readout From Turn‐On to Red‐Shift

European Journal of Organic Chemistry, EarlyView.
DNA architectures with aminonaphthalimides and cyanovinylenes as base surrogates form interstrand and intrastrand dimers showed that can be used as nucleic acid‐sensitive probes by their fluorescence turn‐on and red‐shift as readouts. The fluorescence turn‐on was tested by probing N6‐methyl‐2’‐deoxyadenosine (m6A) in DNA.
Jan Kunzmann, Anna‐Lena Ruopp, Hans‐Achim Wagenknecht   +2 more
wiley   +1 more source

(E)-N′-(4-Fluorobenzylidene)-5-methyl-2-(pyridin-3-yl)thiazole-4-carbohydrazide

Molbank, 2019
5-methyl-2-(pyridin-3-yl)-1,3-thiazole-4-carbohydrazide (1) on treatment with 4-fluorobenzaldehyde in presence of catalytic amount of acetic acid, accessed the target compound (2) with the yield of 79%.
Vinuta Kamat, Rangappa Santosh, Suresh P. Nayak   +2 more
doaj   +1 more source

Accessing Heterocycle‐Containing Borazine Frameworks via C−H Functionalization Reactions of Heterocycles

European Journal of Organic Chemistry, EarlyView.
A Pd/Cu cooperative catalytic system enables the direct C–H functionalization of a diverse range of five‐membered and benzo‐fused heterocycles with iodinated hexaarylborazines, providing efficient access to previously inaccessible heterocycle‐functionalized borazines.
Fan Huang, Giulia Brufani, Ejdi Cela, Alireza Nazari Khodadadi, Dario Marchionni, Luigi Vaccaro   +5 more
wiley   +1 more source

Synthesis and Structural Study of Iodonium Ylides Derived From 2‐Iodosylbenzenesulfonic Acid: Reagents for Preparation of Annulated Thiazoles

European Journal of Organic Chemistry, EarlyView.
New ylides of two different types were prepared by reaction of 2‐iodosylbenzenesulfonic acid with the corresponding 1,3‐cyclohexanediones under acidic or basic conditions. These compounds have a typical for iodonium ylides structure with the CIC angles 94.18° –97.25° and the IC bond distances between 2.08 and 2.13 Å.
Dmitry M. Noskov, Matvey K. Shurikov, Irina A. Mironova, Natalia S. Soldatova, Akira Yoshimura, Akio Saito, Mekhman S. Yusubov, Viкtor V. Zhdankin   +7 more
wiley   +1 more source

Organic Photodetectors and Sensors for Low‐Light and Infrared Applications

Electron, EarlyView.
This mini review highlights recent advances in organic photodetectors and sensors for low‐light and infrared applications, emphasizing molecular design, device architectures, and interface engineering that improve charge transport, detectivity, speed, and spectral selectivity.
Swarup Biswas, Hyeok Kim
wiley   +1 more source