Results 71 to 80 of about 35,784 (226)

Dosing PPARγ Activation With Light Using Fast Relaxing Photoswitches

Angewandte Chemie International Edition, EarlyView.
To achieve spatiotemporal control over PPARγ activity, we designed the fast‐relaxing photoswitchable agonist 6 that selectively activates PPARγ in its light‐induced Z‐state and relaxes within seconds (t1/2 47 s) to the inactive E‐state. This unique profile allowed light‐dosed receptor activation in in vitro settings, enabling biological studies on ...
Loris Knümann, Alba Rodriguez‐Paniagua, Martin Reynders, Silke Duensing‐Kropp, Oliver Thorn‐Seshold, Vasily Morozov, Julian A. Marschner, Daniel Merk   +7 more
wiley   +1 more source

Some Studies in Sulfadiazine Incorporating Pyridine, Pyrimidine, Oxadiazole, and Azo Moieties Endowed with Pharmaceutical Potency

Acta Chimica Slovenica, 2020
A set of substituted sulfadiazine compounds was prepared as cytotoxic and antitumor agents by using 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide (1) as the starting material.
Sherihan El-Hadidy, Sraa Abu-Melha
doaj   +1 more source

Pharmaceutical perspectives of thiazole analogues: An overview

Results in Chemistry
Thiazole derivatives have attracted considerable attention in medicinal chemistry due to their promising biological activities. This review article provides a comprehensive overview on the pharmaceutical applications of the thiazole derivatives ...
Archana R. Patil, Basappa C. Yallur, Sampath Chinnam, Guddekoppa S. Ananthnag, C.R. Santhosh, Geetika Pant, S.G. Prasanna Kumar, Manjuanth D. Hadagali   +7 more
doaj   +1 more source

6′-(3-Bromophenyl)-7′-nitro-1′,6′,7′,7a'-tetrahydro-3′H-spiro[indeno[1,2-b]quinoxaline-11,5′-pyrrolo[1,2-c]thiazole]

IUCrData, 2018
The title compound, C26H19BrN4O2S, crystallizes in a monoclinic C-centred lattice with eight molecules in the unit cell. The five-membered thiazole and pyrrolidine rings adopt envelope conformations and the bromophenyl and indenoquinoxaline planes are ...
C. Muthuselvi, M. Muthu, S. Athimoolam, B. Ravikumar, S. Pandiarajan, R. V. Krishnakumar   +5 more
doaj   +1 more source

Wood Sawdust as a Low‐Cost Filler in Whole‐Tire Reclaimed Rubber: Mechanical Characterization and Factory‐Scale Cost Analysis

Journal of Applied Polymer Science, EarlyView.
Whole‐tire reclaimed rubber is upgraded with wood sawdust, a carpentry by‐product available at no cost, across loadings from 0 to 20 wt%. At 5 wt%, tensile strength, elongation, hardness, viscosity, and water absorption all stay within commercial specification, and real factory data show an annual production saving near $62,000 with no capital ...
Mohammed S. Matar, Faris Tarlochan, Sami E. Alkhatib, Abdullah Abdelhamid   +3 more
wiley   +1 more source

Short Review on Thiazole Derivative [PDF]

, 2019
Thiazole is aromatic, heterocyclic organic compound that have five membered molecular ring structures C3H3NS. Thiazole was first described by Hantzch and Weber in 1887. Prop confirmed its structure in 1889.
Pradhan, Alka, Qureshi, Abida
core   +1 more source

Comprehensive review on coumarin–thiazole hybrids: Synthesis, characterization, in silico studies, and biological perspectives

Bulletin of Pharmaceutical Sciences. Assiut University
The hybrid molecules with various pharmacological actions are believed to emerge on the combination of coumarin and thiazole scaffolds. The bioactive scaffolds of coumarin and thiazole comprise such derivatives and have a broad spectrum of biological ...
Noor Abd Alhassan, Leaqaa Abd Ridha
doaj   +1 more source

Synthesis and biological activity evaluation of new functionally substituted 5-arylidene-2,4-dioxotetrahydro-1,3-thiazoles [PDF]

Journal of the Serbian Chemical Society, 2006
New functionally substituted 5-arylidene-2,4-dioxotetrahydro-1,3-thiazole-3-carboxylic acid cholesteryl esters were synthesized from 2,4-dioxotetrahydro-1,3-thiazole and evaluated for their in vitro cytotoxicity against several human tumor cell lines and
MIROSLAV PERGAL, MILICA RANCIC, KATARINA POPOV-PERGAL, GORDANA BOGDANOVIC, VESNA KOJIC, DEJAN DJOKOVIC   +5 more
doaj  

(E)-N′-(4-Fluorobenzylidene)-5-methyl-2-(pyridin-3-yl)thiazole-4-carbohydrazide

Molbank, 2019
5-methyl-2-(pyridin-3-yl)-1,3-thiazole-4-carbohydrazide (1) on treatment with 4-fluorobenzaldehyde in presence of catalytic amount of acetic acid, accessed the target compound (2) with the yield of 79%.
Vinuta Kamat, Rangappa Santosh, Suresh P. Nayak   +2 more
doaj   +1 more source

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, EarlyView.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source