Results 111 to 120 of about 46,327 (259)
MYC in Oncogenesis and Therapeutic Implications
MedComm, Volume 7, Issue 8, August 2026.The MYC oncogene family (c‐MYC, N‐MYC, L‐MYC) functions as a central transcriptional hub orchestrating cancer progression through multiple interconnected pathways. This graphical abstract illustrates MYC's role as a multidimensional regulator positioned at the nexus of tumor microenvironment remodeling, metabolic reprogramming, and therapeutic ...
Na Zhang +5 more
wiley +1 more source
Azole‐Based Diarylbenzenes for Molecular Solar Thermal Energy Storage: A Computational Analysis
ChemistrySelect, Volume 11, Issue 29, 3 August 2026.Diarylethenes containing aromatic π‐linkers have attracted research interest in recent years owing to their potential applications in molecular solar thermal (MOST) energy storage systems. In this work, we demonstrate that replacing the thienyl core of diarylbenzenes with an oxazole core and introducing lateral alkyl‐substituents on the oxazole core ...
Thillaiarasi Sukumar +5 more
wiley +1 more source
Exploring Biological Properties of Manganese(II)‐Phenanthroline‐Based Complexes: In Vitro Insights
ChemistrySelect, Volume 11, Issue 29, 3 August 2026.Four Mn(II) complexes with phenanthroline derivatives were studied. These compounds were tested against several parasites and different human cancer cells. Despite its cytotoxicity on breast cancer, DNA seems not to be the main biological target. These complexes can drive the design and development of new metal‐based agents with improved biological ...
Roberto S. Silva +16 more
wiley +1 more source
Pyridine C─N Transposition via Cycloaddition–Cycloreversion
Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.Transposition of pyridine nitrogen from the 4‐ to the 3‐position is described using two open and shut sequences: a nucleophile addition ring‐open ring‐closure, followed by a nitrile Diels–Alder cycloaddition cycloreversion. The nitrogen swap is particularly effective for tertiary alkyl substituents, transforming easily accessible para‐alkylated ...
Aífe Conboy, Michael F. Greaney
wiley +2 more sources
Late‐Stage Functionalization of Peptides on the Solid Phase
Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner +2 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.We present a bioluminescent diagnostic platform that integrates DNA amplification and detection in a single step. The engineering of thermostable luciferase‐intercalating dye conjugates and controlled release of caged luciferin substrates enable real‐time, detection of attomolar concentrations of viral DNA within 30 min.
Yosta de Stigter +8 more
wiley +2 more sources
On Oxalyl Halide Isothiocyanates Part I: Syntheses and Isomerism
European Journal of Inorganic Chemistry, Volume 29, Issue 21, 25 July 2026.Oxalyl halide isothiocyanates can be prepared from oxalyl halide with one equivalent of NH4SCN in liquid SO2. While oxalyl bromide isothiocyanate can be isolated as a liquid, the respective chloride compound readily undergoes isomerization under formation of a thiazole ring, which is obtained as a solid.
Sven Ringelband +2 more
wiley +1 more source
, 1974 Department of Chemistry, Punjab University, Chandigarh-160014 Manuscript received 11 February 1974; accepted 20 August 1974 Some Pyrazolo(3,4-d)-thiazoles have been synthesised by the condensation of phenyl thioureas with 4-bromo-1,3 diphenyl pyrazolone-5. However, In each case, two products have been isolated.
H. K. GAKHAR, VED PARKASH, KUL BHUSHAN
openaire +1 more source
Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.Dies beschreibt die ersten enantioselektiven Alkinylierungen wässrigen Fluorals. Diese Prozesse werden durch einen Iodid‐gebundenen Ruthenium‐(Ph‐BPE)‐Komplex katalysiert, welcher als oktaedrischer Metallkomplex in 12 verschiedenen stereoisomeren Formen vorliegen kann.
Weijia Shen +6 more
wiley +1 more source