Results 131 to 140 of about 49,222 (248)

Modulating IDO1 and TDO Inhibition Through Structural Modification of Diaryl Hydroxylamines

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Diaryl hydroxylamines have emerged as promising scaffolds for targeting the tryptophan‐catabolizing enzymes indoleamine 2,3‐dioxygenase 1 (IDO1) and tryptophan 2,3‐dioxygenase (TDO), key drivers of tumor immune escape. Building on the reported dual IDO1/TDO inhibitory activity of O‐((3,5‐difluorophenyl)(phenyl)methyl)hydroxylamine, a series of diaryl ...
Angeliki S. Foscolos, Alexandros Pappas, Christos N. Petroulias, Anna Kapella, Georgia M. Prifti, Grigoris Zoidis, Minas Papadopoulos, Anastasia Mpakali, Aristeidis Chiotellis   +8 more
wiley   +1 more source

Comparison of DNA and RNA quantification methods suitable for parameter estimation in metabolic modeling of microorganisms [PDF]

, 2006
De Maeseneire, Sofie, De Mey, Marjan, Lequeux, Gaspard, Maertens, Jo, Soetaert, Wim, Vandamme, Erick   +5 more
core   +1 more source

2-((5-(3-(2-Fluorophenyl)acryloyl)-4-methylthiazol-2-yl)amino)isoindoline-1,3-dione

Molbank
In this work, the title compound was synthesized via the Claisen–Schmidt condensation of a 2-((5-acetyl-4-methylthiazol-2-yl)amino)isoindoline-1,3-dione with 2-fluorobenzaldehyde. The structure of the synthesized compound (yield 62%) was confirmed by 1H,
Olha-Maria Fedusevych, Andrii Lozynskyi, Marta Sulyma, Roman Lesyk   +3 more
doaj   +1 more source

Heteroaryl‐Substituted Polyfluorobiaryls Synthesis via Palladium‐Catalyzed Double C─H Bond Functionalization Using Palladium 1,4‐Migration Associated to Direct Arylation

European Journal of Organic Chemistry, Volume 29, Issue 13, 13 April 2026.
Fluoro substituents on a benzene ring linked to a 2‐bromoaryl group enables the selective activation of one of its C─H bonds via Pd‐1,4‐migration. Then, Pd‐catalyzed direct coupling with heteroarenes produces C2’‐heteroarylated 1,1′‐biaryls. In this reaction, the new C–C bond arises from the functionalization of two C─H bonds.
Norman Le Floch, Thierry Roisnel, Henri Doucet   +2 more
wiley   +1 more source

Quantitative Structure-Property Relationships for Predicting the Retention Indices of Fragrances on Stationary Phases of Different Polarity [PDF]

, 2017
El objetivo de este trabajo fue el desarrollo de relaciones cuantitativas estructura–propiedad predictivas para el modelado de índices de retención (I) de fragancias, medidas en tres fases estacionarias de diferente polaridad: DB–225MS, HP5–MS y HP–1. Se
Duchowicz, Pablo Román, Pis Diez, Reinaldo, Rojas Villa, Cristian Xavier, Tripaldi, P.   +3 more
core   +1 more source

Thiazole Effect on Phycomyces [PDF]

Proceedings of the National Academy of Sciences, 1941
W J, Robbins, F, Kavanagh
openaire   +2 more sources

Coumarin thiazole-derived Schiff base copper complex: synthesis, characterization, and applications in the catalytic degradation of dyes, pearl millet seed germination for improved agricultural output and antioxidant assays. [PDF]

RSC Adv
Sharma N, Kanchan, Shrivastava R.
europepmc   +1 more source

Structure elucidation and evaluation of the antimicrobial and antitumor activities of 5-methylthiazole-based Schiff base and its metal chelates. [PDF]

Sci Rep
Wahdan KM, Mandour HSA, El-Ghamry HA, El-Gamil MM, Khedr AM.   +4 more
europepmc   +1 more source

Discovery of a Novel Coumarin/Thiazole Chalcone Hybrid as a Potent Dual Inhibitor of Tubulin and Carbonic Anhydrases IX & XII with Promising Anti-Proliferative Activity. [PDF]

Molecules
Saleem BAA, Qurtam AA, Ahmed M, Al-Aouadi RFA, Alrikabi AAA, Hetta HF, Bräse S, Alotaibi G, Alkhammash A, Farhan SM.   +9 more
europepmc   +1 more source

Design, green synthesis, and bioevaluation of 1,3-thiazole-sulfonamide hybrids as antimicrobial and anti-inflammatory agent. [PDF]

Sci Rep
Alrayes AA, Alshammari AQ, Alshammari AQ, Elkanzi NAA, Ali AM.   +4 more
europepmc   +1 more source