Results 131 to 140 of about 46,327 (259)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Exploiting Dimensionality in Hybrid Metal Halides: Design Strategies, Structure–Property Relationships, Optoelectronic Applications, and Future Perspectives

Small Structures, Volume 7, Issue 7, July 2026.
This review presents a unified structural classification for hybrid metal halides from 3D to 0D. It summarizes dimensional engineering strategies and dimension‐dependent structure–property relationships, offering a systematic framework to guide the design and development of high‐performance low‐dimensional optoelectronic materials.
Ying Liu, Xingyao Zhao, Hongyu Ju, Bin–Bin Cui   +3 more
wiley   +1 more source

Trace Element Analysis in Human Neuroblastoma Cell Spheroids Supplemented With ZnCl2 by Micro‐XRF

X-Ray Spectrometry, Volume 55, Issue 4, Page 545-552, July/August 2026.
ABSTRACT Neuroblastoma, the most common extracranial solid tumor of childhood, is responsible for ~10% of pediatric cancer deaths and has high potential for metastasis. Metals are extremely important in biological processes, and changes in their levels have been correlated with the development of cancerous growth.
J. E. P. Rosa, R. G. Leitão, G. C. Ferreira, C. Palmero, E. G. Oliveira‐Barros, M. A. Oliveira, C. G. L. Canellas, L. E. Nasciutti, D. F. Olivera, R. T. Lopes, M. J. Anjos   +10 more
wiley   +1 more source

Unusual backfolded binding poses of BAZ2A bromodomain binders

Acta Crystallographica Section D, Volume 82, Issue 7, Page 776-784, July 2026.
We identified BAZ2A‐binding compounds assuming a peculiar, almost enclosed, conformation. These molecules pose a basis for the development of potent BAZ2A macrocyclic inhibitors, as performed for other bromodomains.BAZ2A is a large multidomain protein overexpressed in aggressive prostate cancer, where it potentiates migration and invasion of other ...
Andrea Dalle Vedove, Giulia Cazzanelli, Vito Giuseppe D'Agostino, Pablo Andres Vargas Rosales, Amedeo Caflisch, Graziano Lolli   +5 more
wiley   +1 more source

The LAV‐BPIFB4‐Platelet‐CD47 Axis: A Novel Mechanism Associated With Immune Resilience in Longevity

Aging Cell, Volume 25, Issue 7, July 2026.
Centenarians display elevated CD47+ reticulated platelets, a trait recapitulated in LAV‐BPIFB4 carriers on total platelet pool. LAV‐BPIFB4 drives an early acquirement of CD47 surface expression, enabling platelets to suppress monocyte IL‐6 release. rhLAV‐BPIFB4 phenocopies the effects in non‐genetic carriers, establishing the platelet–CD47–monocyte ...
Elena Ciaglia, Roberta Maria Esposito, Valentina Lopardo, Francesco Montella, Cristina Basile, Roberta Longo, Anna Maciag, Giuseppe Rescigno, Antonio Damato, Francesco Del Plato, Alfonso Finizio, Carmine Vecchione, Albino Carrizzo, Annibale Alessandro Puca   +13 more
wiley   +1 more source

Theoretical and Experimental Study of the Effect of Functional Groups on the Thiazole-5H Proton Chemical Shift in ¹H NMR Spectroscopy. [PDF]

Materials (Basel)
Baranowska-Łączkowska A, Łączkowski KZ.   +1 more
europepmc   +1 more source

Design, Synthesis of Pyridine Based Thiazolidine Derivatives and Investigation of Antimicrobial Activity Targeting Ergosterol Biosynthesis via In Vitro and In Silico Approaches

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
Synthesis of thiazolidine derivatives and investigation of their antimicrobial activities. ABSTRACT Pyridine and thiazolidine ring systems are unique heterocyclic rings since they are present in the structure of various drug/drug‐like molecules and reported in many studies for their distinct biological effects.
Aybüke Züleyha Kaya, Asaf Evrim Evren, Ülküye Dudu Gül, Halide Edip Temel, Leyla Yurttaş   +4 more
wiley   +1 more source

Design, Synthesis, and Evaluation of Novel Thiazole-Based Peptidomimetic Compounds as Potent SARS-CoV-2 Main Protease Covalent Inhibitors. [PDF]

ACS Infect Dis
Yin W, Kong WP, Leung SL, Liang Z, Chen YW, Wong KY.   +5 more
europepmc   +1 more source

Synthesis, Characterization, Molecular Docking Study and Biological Evaluation of Novel 1,3,4‐Thiadiazole‐Based Heterocycles as Potential Anticancer and Antioxidant Agents

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
A new cyanoacetohydrazide derivative was developed as a key intermediate to synthesize diverse 1,3,4‐thiadiazole‐based heterocyclic compounds. The synthesized compounds were structurally confirmed. Several compounds demonstrated strong cytotoxic activity against HePG‐2 and MCF‐7 cancer cell lines, with compounds 17, 18, and 13 exceeding the activity of
Nashwa M. El‐Metwaly, Abdulmajeed F. Alrefaei, Hossa F. Alshareef, Samar J. Almehmadi, Fatimah A. Alotaibi, Nadiyah M. Alshammari, Manal S. Ebaid, Hanadi A. Katouah   +7 more
wiley   +1 more source

Isoxazole-Thiazole Hybrids: Synthesis, Structural Characterisation, Carbonic Anhydrase Inhibition, and Molecular Docking Studies. [PDF]

Molecules
Berber N, Türkeri ÖN, Başoğlu F, Çıkrıkcı K, Ergün A, Gencer N.   +5 more
europepmc   +1 more source