Results 141 to 150 of about 59,616 (308)
Plant Biotechnology Journal, EarlyView.ABSTRACT Soybean is a critical source of protein and vegetable oil worldwide. Expanding its cultivation into salinity lands represents a promising strategy for increasing production; however, soil salinity severely limits soybean growth by disrupting physiological and metabolic homeostasis.
Wanying Zhang +13 more
wiley +1 more source
Conformational dynamics in insulin receptor kinase reveal a type III allosteric pocket
Protein Science, Volume 35, Issue 2, February 2026.Abstract Allosteric modulation is a promising strategy for selective kinase inhibition, yet structural insights into allosteric pockets remain limited across the human kinome. In this work, we present comprehensive characterization of a type III allosteric pocket in the insulin receptor kinase (IRK), integrating structural, conformational, and ...
Jyoti Verma, Harish Vashisth
wiley +1 more source
Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.This work explores the complex relationship between soil carbon availability and microplastic biodegradation, highlighting competition and symbiosis among microorganisms, the repurposing of microplastic‐derived polymers, and the impact of soil organic carbon on microbial substrate preferences and carbon use efficiency variability.
Mohammad Yaghoubi Khanghahi +3 more
wiley +1 more source
Thiazole Ring—A Biologically Active Scaffold [PDF]
, 2021 Anthi Petrou +2 more
openalex +1 more source
Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.Proteolysis‐targeting Chimeras (PROTACs) ermöglichen die gezielte Degradation bislang als „undruggable“ geltende Proteine über das zelluläre Ubiquitin–Proteasom‐System. In dieser Studie identifizieren Schäfer et al. thiazolbasierte niedermolekulare Liganden, die allosterisch an die Zinkfinger‐Domäne der Ubiquitin‐spezifischen Protease 39 (USP39) binden
Daniel Schäfer +11 more
wiley +1 more source
Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC‐Induced Degradation
Angewandte Chemie International Edition, Volume 65, Issue 5, 28 January 2026.Proteolysis‐targeting chimeras (PROTACs) enable degradation of proteins previously considered undruggable by harnessing the cellular ubiquitin–proteasome system. In this study, Schäfer et al. identify thiazole‐based small molecules that allosterically bind the zinc finger domain of ubiquitin‐specific protease 39 (USP39), a non‐enzymatic scaffold ...
Daniel Schäfer +11 more
wiley +1 more source
Frame‐Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design
Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.Modern chemistry seeks to turn the simple raw materials into complex molecules that matter in health, agriculture, and technology. Among these, oligoheterocycles stand out for their versatility, yet they are most often built by cross‐coupling reactions that often rely on expensive metal catalysts.
Kane A. C. Bastick +6 more
wiley +2 more sources
Types and properties of metal-free catalysts for living polymerizations of biomaterials [PDF]
, 2008 Syntéza biokompatibilních a biodegradabilních polyesterů, použitelných převážně v medicíně, využívá pro polymeraci za otevření kruhu katalyzátory na bázi kovu (např. Sn, Al atd.), které se mohou po implantaci deponovat v těle.
Repka, Martin
core
Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.Pseudotetraivprolid ist ein neuer Akteur unter den Detoxin/Rimosamid‐ähnlichen Naturstoffen. Die Biosynthese erfordert FabD aus dem Primärstoffwechsel und einen PipDFG‐Komplex für die Acetylierung im letzten Schritt – wodurch schließlich die anti‐antibiotische Wirkung entsteht.
Edna Bode +13 more
wiley +1 more source