Results 121 to 130 of about 44,050 (359)

From Hydroborations Catalyzed by Sn(II) Cations to Photoluminescent Boronic Esters

ChemCatChem, EarlyView.
The N‐coordinated Sn(II) cation was found as efficient catalyst for the hydroboration of a broad range of substrates including substituted benzaldehydes, heterocyclic carbaldehydes, aliphatic aldehydes as well as ketones. It was also used in large‐scale hydroboration reactions of pyridine‐substituted carbaldehydes, which were characterized by NMR ...
Ondřej Moždiak, Tomáš Bíza, Lukáš Střižík, Zdeňka Růžičková, Milan Erben, Libor Dostál, Emanuel Hupf, Roman Jambor   +7 more
wiley   +1 more source

Synthesis and Antimicrobial Evaluation of 2-[2-(9H-Fluoren-9-ylidene)hydrazin-1-yl]-1,3-thiazole Derivatives

Molbank
Fluorenyl-hydrazonothiazole derivatives 2–7 were synthesized by the Hantzsch reaction from 2-(9H-fluoren-9-ylidene)hydrazine-1-carbothioamide (1) and the corresponding α-halocarbonyl compounds in THF or 1,4-dioxane solvent.
Kazimieras Anusevičius, Ignė Stebrytė, Povilas Kavaliauskas   +2 more
doaj   +1 more source

Total syntheses of linear polythiazole/oxazole plantazolicin A and its biosynthetic precursor plantazolicin B. [PDF]

, 2014
Plantazolicin A, a linear decacyclic natural product, exhibits desirable selective activity against the causative agent of anthrax toxicity. The total synthesis of plantazolicin A and its biosynthetic precursor plantazolicin B was successfully achieved ...
Aguilar, Banala, Bredenkamp, Burrell, Cohen, Conroy, Di Credico, Fleury, Hamada, Hernández, Kalyon, Ko, Lafargue, Lee, Melby, Merritt, Molohon, Nicolaou, Nicolaou, North, Phillips, Piwowarska, Scholz, Sharma, van der Donk, Yonezawa   +25 more
core   +2 more sources

Nitrones as Versatile Linkages for the Construction of Covalent Organic Polymers by Tandem Transformations

ChemistryEurope, EarlyView.
The nitrone moiety's versatility in covalent organic polymer (COP) materials is shown by its ability to form either nitrone‐linked or oxime O‐ether‐linked COPs from the same building blocks, simply by changing reaction conditions. Additionally, its 1,3‐dipolar cycloaddition reactivity enabled the synthesis of a functionalized isoxazolidine‐linked ...
Beatriz de Santos, M. José Capitán, Jesús Álvarez, Isabel Sobrados, Silvia Cabrera, Alberto Fraile, José Alemán   +6 more
wiley   +1 more source

Condensation of 4-hydroxy-2-thiazolines with 1,2-phenylenediamine as a novel effective route to thiazolo[3,4-a]quinoxalines [PDF]

, 2004
Thiazolo[3,4-a]quinoxalin-4-ones were prepared in two steps starting from methyl phenylchloropyruvate using a new strategy for the construction of the ring system. A key step in this new method involves the reaction of 4-hydroxytetrahydrothiazoles with 1,
Gubaidullin, Aidar T, Litvinov, Igor A, Mamedov, Vakhid A., Nurkhametova, Ilsiyar Z, Tsuboi, Sadao   +4 more
core   +1 more source

Targeting Ubiquitin‐Specific Protease 7 with Novel 5‐Amino‐Pyrazole Inhibitors: Design, Synthesis, and Biological Evaluation

ChemMedChem, EarlyView.
Ubiquitin‐specific protease 7 (USP‐7) is a novel target for anticancer therapy. To further extend the structure–activity relationships of the previously USP‐7 inhibitor STIRUR‐41, a library of 5‐aminopyrazoles is reported. 1d shows a potency comparable to lead compound STIRUR‐41 and promising in silico and in vitro pharmacokinetic properties ...
Matteo Lusardi, Elva Morretta, Andrea Spallarossa, Maria Chiara Monti, Camillo Rosano, Erika Iervasi, Marco Ponassi, Matteo Mori, Fiorella Meneghetti, Chiara Brullo   +9 more
wiley   +1 more source

Green synthesis of highly functionalized octahydropyrrolo[3,4-c]pyrrole derivatives using subcritical water, and their anti(myco)bacterial and antifungal activity [PDF]

, 2018
A series of novel 2-(thiazol-2-yl)-octahydropyrrolo[3,4-c]pyrroles was synthesized by reaction of octahydropyrrolo[3,4-c]pyrrole N-benzoylthiourea derivatives and α-haloketones in subcritical water at 130 °C in 75-91% yield.
De Coen, Laurens, Gemili, Muge, Nural, Yahya, Ulger, Mahmut, Yabalak, Erdal   +4 more
core   +1 more source

Development of Carborane‐Based Halogenated Naphthyridinone‐Analogues as Cannabinoid Receptor Type 2 (CB2R) Ligands

ChemMedChem, EarlyView.
There is no suitable radioligand for positron emission tomography imaging of CB2R overexpression for routine clinical usage. Herein, the synthesis, characterization, binding affinity, and docking studies of carborane‐based halo‐substituted naphthyridinone derivatives as CB2R ligands are presented.
Lea Ueberham, Winnie Deuther‐Conrad, Peter Lönnecke, Aleksandr Kazimir, Evamarie Hey‐Hawkins   +4 more
wiley   +1 more source

Unveiling Benzoxazole‐Substituted Thiazolyl‐Pyrazole Derivatives Inducing Apoptosis by Targeting β‐Tubulin and Caspase‐3

ChemMedChem, EarlyView.
BP(1‐6) compounds designed from Benzoxazole and Thiazolyl‐Pyrazole scaffolds exhibited potent antitubulin and caspase‐3 activity in MDA‐MB‐231 cells. BP‐6 notably triggered apoptosis and disrupted cell proliferation. Docking studies validated strong binding affinities of BP‐2 and BP‐6 toward β‐tubulin and caspase‐3, suggesting promising therapeutic ...
Burak Kuzu, Mustafa Cakir, Eda Acikgoz, Mehmet Abdullah Alagoz   +3 more
wiley   +1 more source

Low‐Micromolar Quantification of Fluorinated Analytes Using Hyperpolarized 19F Benchtop Nuclear Magnetic Resonance

Chemistry–Methods, EarlyView.
Limits of detection and quantification of fluorinated analytes by 19F benchtop (1 T) NMR spectroscopy in the high nanomolar to low micromolar range are achieved using signal amplification by reversible exchange (SABRE) combined with the multiplet‐refocusing technique, SHARPER (Sensitive, Homogeneous, And Resolved PEaks in Real time).
Ana I. Silva Terra, Meghan E. Halse
wiley   +1 more source