Results 91 to 100 of about 14,774 (209)
A New Electrochemical Sensor for Direct Detection of Purine Antimetabolites and DNA Degradation
Journal of Analytical Methods in Chemistry, 2019 The development of a reliable electrochemical sensor using a hybrid nanocomposite consisting of ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate) functionalized graphene oxide (GrO-IL) and gold nanoparticles (AuNPs) stabilized by chitosan ...
Liliya K. Shpigun, Elena Yu. Andryukhina
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Analytical Cellular Pathology, 2019 Aim. This study is aimed at investigating the effect of Shogaol, a phenolic constituent of ginger, on dextran sodium sulfate- (DSS-) induced ulcerative colitis (UC) in mice in comparison with 6-thioguanine (6-TG), an immune-suppressant chemotherapeutic ...
Snur M. A. Hassan, Ali Hussein Hassan
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Electrochemical oxidation of 6-thioguanine
Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, 1986 Abstract The electrochemical exidation pathway of 6-thioguanine was investigated by cyclic voltammetry, constant-potential electrolysis, coulometry, UV/VIS spectroscopy and mass spectrometry. Experimental evidence indicates that the oxidation pathway depends on potential.
Department of Chemistry, University of Florida Gainesville, FL 32611 U.S.A. ( host institution ) +2 more
openaire +2 more sources
Analytical Validation of Variants to Aid in Genotype-Guided Therapy for Oncology [PDF]
, 2019 The Clinical Laboratory Improvement Amendments (CLIA) of 1988 requires that pharmacogenetic genotyping methods need to be established according to technical standards and laboratory practice guidelines before testing can be offered to patients.
Kiel, Patrick J. +7 more
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Perspectives and Prospects in the Chemotherapy of Gastrointestinal Cancer [PDF]
, 1967 5-Flourouracil (5-FU) is the best agent for the treatment of all gastrointestinal cancers but should be used with restraint, since severe toxicity does not guarantee increased response or survival time.
Regelson, William
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, 2014 Purpose of review: Long-term survival of liver transplant recipients is threatened by increased rates of de-novo malignancy and recurrence of hepatocellular carcinoma (HCC), both events tightly related to immunosuppression.
Burroughs, AK +2 more
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PLoS ONE, 2019 BackgroundThe recently established association between higher levels of DNA-incorporated thioguanine nucleotides and lower relapse risk in childhood acute lymphoblastic leukaemia (ALL) calls for reassessment of prolonged 6-thioguanine (6TG) treatment ...
Linea Natalie Toksvang +6 more
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Suspected azathioprine induced liver cirrhosis: an unusual side effect
The Pan African Medical Journal, 2014 In recent years, the hepatotoxic potential of thiopurines, in particular 6-thioguanine (6-TG) has been discussed in literature. However, cirrhosis was exceptionally reported.
Aida Ben Slama Trabelsi +5 more
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, 2019 This work describes the decay mechanism of photoexcited thiourea, both in gas phase and in solution, from the information inferred from the topography of the excited and ground state potential energy surfaces and mixed singlet/triplet quantum classical ...
Corral, Ines +3 more
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CAS9 is a genome mutator by directly disrupting DNA-PK dependent DNA repair pathway. [PDF]
, 2020 With its high efficiency for site-specific genome editing and easy manipulation, the clustered regularly interspaced short palindromic repeats (CRISPR)/ CRISPR associated protein 9 (CAS9) system has become the most widely used gene editing technology in ...
Chen, Qu +6 more
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