Results 81 to 90 of about 14,774 (209)

Perforating dermatosis in a patient receiving azathioprine

Indian Journal of Dermatology, 2013
Azathioprine (AZA) is an imidazole derivative of mercaptopurine. It antagonizes purine metabolism, and it may inhibit synthesis of DNA, RNA, and proteins.
Emiliano Grillo, Sergio Vano-Galván, Carmen Moreno, Pedro Jaén   +3 more
doaj   +1 more source

Pulse Dosing of Thioguanine in Recalcitrant Psoriasis [PDF]

Archives of Dermatology, 1999
Patients with severe psoriasis may be unresponsive to or unable to tolerate the adverse effects of traditional therapy. Thioguanine has been used to treat psoriasis, but experience is limited. Most previous studies have used daily therapy and have demonstrated significant hematologic abnormalities.To reduce the adverse effects of traditional ...
N G, Silvis, N, Levine
openaire   +2 more sources

A rare case of pediatric autoimmune pancreatitis and autoimmune hepatitis in a patient with sickle cell disease

JPGN Reports, Volume 7, Issue 1, Page 142-146, February 2026.
Abstract Concurrent pediatric autoimmune pancreatitis (AIP) and autoimmune hepatitis (AIH) are rarely reported, and no established pediatric‐specific guidelines are available to guide the diagnosis and management of these conditions in children. While AIP and AIH share an underlying autoimmune mechanism of injury, marked by chronic inflammatory changes
Sasha‐Jane Abi‐Aad, Michelle Edward, David Germain, Rene Gomez‐Esquivel, Racha Khalaf   +4 more
wiley   +1 more source

Thiopurine S -methyltransferase polymorphisms: efficient screening method for patients considering taking thiopurine drugs [PDF]

, 2018
Objective: More than 11% of the Caucasian population are heterozygous or homozygous carriers of thiopurine S-methyltransferase (TPMT) mutants and are at risk for toxic side effects when treated with thiopurine drugs.
Fried, M., Kullak-Ublick, G., Rammert, C., Rentsch, K., von Eckardstein, A., Wusk, Barbara   +5 more
core  

Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids [PDF]

, 2012
A broad scientific community is involved in investigations aimed at delineating the mechanisms of formation and cellular processing of oxidatively generated damage to nucleic acids.
Bialkowski, Karol, Cadet, Jean, Cooke, Marcus S., Dedon, Peter C., Evans, Mark D., Greenberg, Marc M., Loft, Steffen, Moller, Peter, Olinski, Ryszard, Richard Wagner, J.   +9 more
core   +1 more source

Unraveling Novel Genetic Determinants of Thiopurine Response Via TWAS

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 84-88, January 2026.
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Thiopurines such as 6‐mercaptopurine (6MP) are essential in ALL maintenance therapy. However, dose‐limiting toxicities can significantly disrupt treatment. While genetic variants in TPMT and NUDT15 are known to affect thiopurine response, many patients with normal function ...
Carlotta Bidoli, Wenjian Yang, Seth E. Karol, Marianna Lucafò, Gabriele Stocco, Jun J. Yang   +5 more
wiley   +1 more source

6-methylmercaptopurine-induced leukocytopenia during thiopurine therapy in inflammatory bowel disease patients [PDF]

, 2017
Background and Aim: Thiopurines have a favorable benefit–risk ratio in the treatment of inflammatory bowel disease. A feared adverse event of thiopurine therapy is myelotoxicity, mostly occurring due to toxic concentrations of the pharmacologically ...
Bodegraven, A.A. (Ad) van, Boer, K.H.N. (Nanne) de, Bouma, G. (Gerd), Derijks, L.J.J., Kreijne, J.E. (Joany), Meijer, B. (Berrie), Mulder, C.J.J. (Chris), van Moorsel, S.A.W. (Sofia A W), Wong, D.R. (Dennis R), Woude, C.J. (Janneke) van der   +9 more
core   +3 more sources

Blinatumomab in de novo AYA ALL—Results of the Australasian Leukaemia and Lymphoma Group ALL09 “SUBLIME” study

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Pediatric regimens improve outcomes in adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL) patients. End‐consolidation (time point 2 [TP2]) minimal residual disease negativity (MRDneg) is associated with improved survival. In this study, standard consolidation chemotherapy was replaced with blinatumomab to improve TP2 MRDneg—a ...
Matthew Greenwood, Shane Gangatharan, Michael Osborn, Ashley P. Ng, Shaun Fleming, Pasquale Fedele, Toby Trahair, John Casey, Sally Mapp, Carol Cheung, Tasman Armytage, Michelle Henderson, Rosemary Sutton, Jacqueline Rehn, Elyse Page, Susan Heatley, Peter Button, Leesa Rowley, Stephen R. Larsen, Peter Presgrave, John Kwan, Samuel Bennett, Chun Yew Fong, Luciano Dalla Pozza, David Yeung, Deborah White, the Australasian Leukaemia and Lymphoma Group   +26 more
wiley   +1 more source

Pharmacogenomic Calling From Whole‐Exome Sequencing in the Taiwanese Population—A Real‐World Experience

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
This study evaluated pharmacogenomic (PGx) calling from whole‐exome sequencing (WES) in 3562 Taiwanese individuals. Fourteen pharmacogenes were reliably identified, with each person carrying an average of ~2.4 actionable phenotypes. The high actionable frequencies of G6PD deficiency and HLA‐B*58:01 highlight ethnic differences and support WES as a ...
Hsu‐Heng Lin, Meng‐Ju Melody Tsai, Hui‐An Chen, Rai‐Hseng Hsu, Yun‐Syuan Lin, Yi‐Lin Lin, Ching Hsu, Yin‐Hsiu Chien, Wuh‐Liang Hwu, Ni‐Chung Lee   +9 more
wiley   +1 more source

Functional toxicology: tools to advance the future of toxicity testing [PDF]

, 2014
The increased presence of chemical contaminants in the environment is an undeniable concern to human health and ecosystems. Historically, by relying heavily upon costly and laborious animal-based toxicity assays, the field of toxicology has often ...
Brandon D. Gaytán, Chris D. Vulpe
core   +2 more sources