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Immune system and thiols: Some peculiarities of thiol exchange
Comparative Immunology, Microbiology and Infectious Diseases, 2010We show that for the system of SH-containing compounds of the organism (cysteine, in particular) there are conditions leading to immunosuppression, which occurs when the level of amino acid cysteine in blood serum increases. The arising "overload" of free sulfhydryl groups inactivates antibodies of the IgM class of any specificity restoring disulphide ...
N K, Rodosskaia, G M, Chernousova
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New Thiols for Photoinitiator‐Free Thiol‐Acrylate Polymerization
Macromolecular Chemistry and Physics, 2013AbstractNew thiols for efficient thiol‐ene polymerization reactions are presented. They do not exhibit any unpleasant odor, are characterized by quite good light‐absorption properties at λ > 300 nm, and generate thiyl radicals upon UV‐light exposure.
Mohamad‐Ali Tehfe +8 more
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ROS, thiols and thiol-regulating systems in male gametogenesis
Biochimica et Biophysica Acta (BBA) - General Subjects, 2015During maturation and storage, spermatozoa generate substantial amounts of reactive oxygen species (ROS) and are thus forced to cope with an increasingly oxidative environment that is both needed and detrimental to their biology. Such a janus-faceted intermediate needs to be tightly controlled and this is done by a wide array of redox enzymes.
Conrad, M. +4 more
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The Journal of Physical Chemistry C, 2011
Self-assembly of organic thiols is the most common way to introduce functional groups onto gold surfaces. Although the gold–sulfur (Au–S) bond is moderately strong (∼45 kcal/mol), it is also prone to oxidation, which substantially weakens the Au–S interaction. In this work, we describe the creation of more robust molecular assemblies on gold.
Madaan, N. +5 more
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Self-assembly of organic thiols is the most common way to introduce functional groups onto gold surfaces. Although the gold–sulfur (Au–S) bond is moderately strong (∼45 kcal/mol), it is also prone to oxidation, which substantially weakens the Au–S interaction. In this work, we describe the creation of more robust molecular assemblies on gold.
Madaan, N. +5 more
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Thiol-dependent and non-thiol-dependent stimulations of insulin release
Diabetes, 1984The effects of reduced glutathione (GSH) and diamide (an oxidant of GSH) on insulin release induced by glucose, glyceraldehyde, leucine, tolbutamide, glibenclamide, Ca-ionophore A-23187, isoprenaline, and db-cAMP were studied using isolated rat pancreatic islets.
H P, Ammon +3 more
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Mini-Reviews in Medicinal Chemistry, 2007
Various classes of cytotoxic compounds which alkylate cellular thiols are described namely alpha,beta-unsaturated ketones, alpha-methylene-gamma-lactones, azines of Mannich bases, imexon, isothiocyanates, a benzoacronycine as well as activation by thiols prior to alkylation.
Hari N, Pati +3 more
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Various classes of cytotoxic compounds which alkylate cellular thiols are described namely alpha,beta-unsaturated ketones, alpha-methylene-gamma-lactones, azines of Mannich bases, imexon, isothiocyanates, a benzoacronycine as well as activation by thiols prior to alkylation.
Hari N, Pati +3 more
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Reaction of alkylcobalamins with thiols
Biochemistry, 1987Carbon-13 NMR spectroscopy and phosphorus-31 NMR spectroscopy have been used to study the reaction of several alkylcobalamins with 2-mercaptoethanol. At alkaline pH, when the thiol is deprotonated, the alkyl-transfer reactions involve a nucleophilic attack of the thiolate anion on the Co-methylene carbon of the cobalamins, yielding alkyl thioethers and
H P, Hogenkamp +2 more
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Thiols as peroxidase substrates
Free Radical Biology and Medicine, 1993The abilities of haem peroxidases to catalyse the oxidation of various thiols were studied using the spin-trapping electron spin resonance (ESR) technique. Myeloperoxidase, a neutrophil and monocyte enzyme, catalysed the oxidation of cysteamine, cysteine methyl, and ethyl ester and to some extent 2-mercaptoethanol and thioglycollic acid.
B E, Svensson +3 more
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Thiols and the chemoprevention of cancer
Current Opinion in Pharmacology, 2007Thiols such as glutathione interfere with the complex carcinogenic process. Under stress conditions, they scavenge harmful molecules: Glutathione conjugation of electrophilic carcinogens may prevent tumor initiation, and reduced thiols may defend against oxidative stress. Thus, associated chemopreventive strategies involve enhancement of antioxidant or
Wolfgang W, Huber, Wolfram, Parzefall
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Nature, 1959
WE have recently shown1,2 that β-mercaptoethanol (a strongly reducing –SH-containing substance) markedly inhibits morphogenetic movements (gastrulation, closure of neural plate) in amphibian eggs. The oxidized counterpart of β-mercaptoethanol (dithiodiglycol) produces a thickening of the neural plate; the same type of abnormalities can be obtained with
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WE have recently shown1,2 that β-mercaptoethanol (a strongly reducing –SH-containing substance) markedly inhibits morphogenetic movements (gastrulation, closure of neural plate) in amphibian eggs. The oxidized counterpart of β-mercaptoethanol (dithiodiglycol) produces a thickening of the neural plate; the same type of abnormalities can be obtained with
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